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Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.

McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

J Mol Recognit. 2013 Feb;26(2):92-103. doi: 10.1002/jmr.2256.


Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

Arch Biochem Biophys. 2010 Feb 15;494(2):216-25. doi: 10.1016/ Epub 2009 Dec 22.


Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

Biochemistry. 2012 Mar 13;51(10):2122-35. doi: 10.1021/bi3000534. Epub 2012 Mar 2.


Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1.

McDonald CB, Seldeen KL, Deegan BJ, Farooq A.

Arch Biochem Biophys. 2008 Nov 1;479(1):52-62. doi: 10.1016/ Epub 2008 Aug 26.


SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.

McDonald CB, Seldeen KL, Deegan BJ, Farooq A.

Biochemistry. 2009 May 19;48(19):4074-85. doi: 10.1021/bi802291y.


Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.

McDonald CB, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

FEBS J. 2012 Jun;279(12):2156-73. doi: 10.1111/j.1742-4658.2012.08600.x. Epub 2012 May 9.


Quantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex.

Sethi A, Goldstein B, Gnanakaran S.

PLoS Comput Biol. 2011 Oct;7(10):e1002192. doi: 10.1371/journal.pcbi.1002192. Epub 2011 Oct 13.


Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands.

Bartelt RR, Light J, Vacaflores A, Butcher A, Pandian M, Nash P, Houtman JC.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2560-9. doi: 10.1016/j.bbamcr.2015.06.002. Epub 2015 Jun 12.


Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.

Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE.

Nat Struct Mol Biol. 2006 Sep;13(9):798-805. Epub 2006 Aug 13.


Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.

Nag A, Monine M, Perelson AS, Goldstein B.

PLoS One. 2012;7(3):e28758. doi: 10.1371/journal.pone.0028758. Epub 2012 Mar 1.


Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity.

Sastry L, Lin W, Wong WT, Di Fiore PP, Scoppa CA, King CR.

Oncogene. 1995 Sep 21;11(6):1107-12.


Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

J Mol Recognit. 2011 Jul-Aug;24(4):585-96. doi: 10.1002/jmr.1080. Epub 2010 Dec 13.


Sos-mediated activation of rac1 by p66shc.

Khanday FA, Santhanam L, Kasuno K, Yamamori T, Naqvi A, Dericco J, Bugayenko A, Mattagajasingh I, Disanza A, Scita G, Irani K.

J Cell Biol. 2006 Mar 13;172(6):817-22. Epub 2006 Mar 6.


Aggregation of membrane proteins by cytosolic cross-linkers: theory and simulation of the LAT-Grb2-SOS1 system.

Nag A, Monine MI, Faeder JR, Goldstein B.

Biophys J. 2009 Apr 8;96(7):2604-23. doi: 10.1016/j.bpj.2009.01.019.


Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells.

Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR.

Mol Cell Biol. 1994 Sep;14(9):5682-91.


Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2).

Baksi S, Basu S, Mukhopadhyay D.

Neurosci Res. 2014 Oct;87:77-83. doi: 10.1016/j.neures.2014.06.009. Epub 2014 Jul 18.


The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.

Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.

Oncogene. 2001 Mar 1;20(9):1052-62.


The isoform-specific stretch of hSos1 defines a new Grb2-binding domain.

Zarich N, Oliva JL, Jorge R, Santos E, Rojas JM.

Oncogene. 2000 Nov 30;19(51):5872-83.


Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.

Lock LS, Frigault MM, Saucier C, Park M.

J Biol Chem. 2003 Aug 8;278(32):30083-90. Epub 2003 May 22.

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