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Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.

Jiang P, Du W, Mancuso A, Wellen KE, Yang X.

Nature. 2013 Jan 31;493(7434):689-93. doi: 10.1038/nature11776. Epub 2013 Jan 13.


Engaging the p53 metabolic brake drives senescence.

Jiang D, Attardi LD.

Cell Res. 2013 Jun;23(6):739-40. doi: 10.1038/cr.2013.34. Epub 2013 Mar 12.


Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence.

Woo SH, Yang LP, Chuang HC, Fitzgerald A, Lee HY, Pickering C, Myers JN, Skinner HD.

Head Neck. 2016 Apr;38 Suppl 1:E934-40. doi: 10.1002/hed.24129. Epub 2015 Jul 18.


Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, MacDonald MJ.

Mol Endocrinol. 2015 Mar;29(3):396-410. doi: 10.1210/me.2014-1249. Epub 2015 Jan 16.


58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.

Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY.

J Biol Chem. 2012 Jun 29;287(27):22533-48. doi: 10.1074/jbc.M111.335331. Epub 2012 May 4.


Identification of domains involved in the allosteric regulation of cytosolic Arabidopsis thaliana NADP-malic enzymes.

Gerrard Wheeler MC, Arias CL, Maurino VG, Andreo CS, Drincovich MF.

FEBS J. 2009 Oct;276(19):5665-77. doi: 10.1111/j.1742-4658.2009.07258.x. Epub 2009 Sep 2.


A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress.

Lee SM, Kim JH, Cho EJ, Youn HD.

Cell Death Differ. 2009 May;16(5):738-48. doi: 10.1038/cdd.2009.5. Epub 2009 Feb 20.


Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

Brown LJ, Longacre MJ, Hasan NM, Kendrick MA, Stoker SW, Macdonald MJ.

J Biol Chem. 2009 Dec 18;284(51):35359-67. doi: 10.1074/jbc.M109.040394.


PTTG1 attenuates drug-induced cellular senescence.

Tong Y, Zhao W, Zhou C, Wawrowsky K, Melmed S.

PLoS One. 2011;6(8):e23754. doi: 10.1371/journal.pone.0023754. Epub 2011 Aug 17.


Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.

Wang YP, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK, Lei QY.

Mol Cell. 2016 Nov 17;64(4):673-687. doi: 10.1016/j.molcel.2016.09.028. Epub 2016 Nov 10.


Hsp27 modulates p53 signaling and suppresses cellular senescence.

O'Callaghan-Sunol C, Gabai VL, Sherman MY.

Cancer Res. 2007 Dec 15;67(24):11779-88.


Repressing malic enzyme 1 redirects glucose metabolism, unbalances the redox state, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines.

Zheng FJ, Ye HB, Wu MS, Lian YF, Qian CN, Zeng YX.

Chin J Cancer. 2012 Nov;31(11):519-31. doi: 10.5732/cjc.012.10088. Epub 2012 Nov 1.


Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress.

Lafontaine J, Tchakarska G, Rodier F, Mes-Masson AM.

BMC Cancer. 2012 Jun 12;12:234. doi: 10.1186/1471-2407-12-234.


Arabidopsis thaliana NADP-malic enzyme isoforms: high degree of identity but clearly distinct properties.

Wheeler MC, Arias CL, Tronconi MA, Maurino VG, Andreo CS, Drincovitch MF.

Plant Mol Biol. 2008 Jun;67(3):231-42. doi: 10.1007/s11103-008-9313-9.


HJURP regulates cellular senescence in human fibroblasts and endothelial cells via a p53-dependent pathway.

Heo JI, Cho JH, Kim JR.

J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):914-25. doi: 10.1093/gerona/gls257. Epub 2013 Jan 4.


Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

López-Vicente L, Armengol G, Pons B, Coch L, Argelaguet E, Lleonart M, Hernández-Losa J, de Torres I, Ramon y Cajal S.

Clin Cancer Res. 2009 Jul 15;15(14):4546-53. doi: 10.1158/1078-0432.CCR-08-3159. Epub 2009 Jul 7.


NAD-malic enzymes of Arabidopsis thaliana display distinct kinetic mechanisms that support differences in physiological control.

Tronconi MA, Gerrard Wheeler MC, Maurino VG, Drincovich MF, Andreo CS.

Biochem J. 2010 Sep 1;430(2):295-303. doi: 10.1042/BJ20100497.


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