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Items: 1 to 20 of 86

1.

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.

Chu J, Praticò D.

Neurobiol Aging. 2013 Jun;34(6):1549-54. doi: 10.1016/j.neurobiolaging.2012.12.009. Epub 2013 Jan 16.

2.

Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.

Chu J, Li JG, Praticò D.

PLoS One. 2013 Aug 7;8(8):e70991. doi: 10.1371/journal.pone.0070991. eCollection 2013.

3.

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice.

Di Meco A, Lauretti E, Vagnozzi AN, Praticò D.

Neurobiol Aging. 2014 Nov;35(11):2458-64. doi: 10.1016/j.neurobiolaging.2014.05.016. Epub 2014 May 27.

4.

Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg mice.

Joshi YB, Chu J, Praticò D.

Aging Cell. 2013 Aug;12(4):706-11. doi: 10.1111/acel.12096. Epub 2013 Jun 11.

5.

The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence.

Chu J, Li JG, Ceballos-Diaz C, Golde T, Praticò D.

Biol Psychiatry. 2013 Sep 1;74(5):321-8. doi: 10.1016/j.biopsych.2012.12.012. Epub 2013 Jan 23.

6.

Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.

Giannopoulos PF, Chu J, Sperow M, Li JG, Yu WH, Kirby LG, Abood M, Praticò D.

Biol Psychiatry. 2015 Nov 15;78(10):693-701. doi: 10.1016/j.biopsych.2015.01.015. Epub 2015 Feb 7.

7.

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.

Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D.

Ann Neurol. 2012 Sep;72(3):442-54. doi: 10.1002/ana.23642.

8.

Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.

Joshi YB, Giannopoulos PF, Chu J, Praticò D.

Neurobiol Aging. 2014 May;35(5):1024-31. doi: 10.1016/j.neurobiolaging.2013.11.016. Epub 2013 Nov 22.

9.

Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease.

Giannopoulos PF, Chu J, Joshi YB, Sperow M, Li JG, Kirby LG, Praticò D.

Mol Psychiatry. 2014 Apr;19(4):511-8. doi: 10.1038/mp.2013.23. Epub 2013 Mar 12.

10.

FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo .

Chu J, Lauretti E, Di Meco A, Praticò D.

Transl Psychiatry. 2013 Dec 3;3:e333. doi: 10.1038/tp.2013.106.

11.
12.

The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo.

Giannopoulos PF, Joshi YB, Chu J, Praticò D.

Aging Cell. 2013 Dec;12(6):1082-90. doi: 10.1111/acel.12136. Epub 2013 Aug 19.

13.

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model.

Chu J, Praticò D.

J Neuroinflammation. 2012 Jun 14;9:127. doi: 10.1186/1742-2094-9-127.

14.

Novel lipid signaling pathways in Alzheimer's disease pathogenesis.

Giannopoulos PF, Joshi YB, Praticò D.

Biochem Pharmacol. 2014 Apr 15;88(4):560-4. doi: 10.1016/j.bcp.2013.11.005. Epub 2013 Nov 21. Review.

15.

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

Joshi YB, Giannopoulos PF, Chu J, Sperow M, Kirby LG, Abood ME, Praticò D.

Hum Mol Genet. 2014 Dec 20;23(25):6894-902. doi: 10.1093/hmg/ddu412. Epub 2014 Aug 13.

16.

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE.

J Neurosci. 2008 Mar 5;28(10):2624-32. doi: 10.1523/JNEUROSCI.5245-07.2008.

17.

12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.

Di Meco A, Li JG, Blass BE, Abou-Gharbia M, Lauretti E, Praticò D.

Biol Psychiatry. 2017 Jan 15;81(2):92-100. doi: 10.1016/j.biopsych.2016.05.023. Epub 2016 Jun 4.

PMID:
27499089
18.

Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.

Padmanabhan J, Levy M, Dickson DW, Potter H.

Brain. 2006 Nov;129(Pt 11):3020-34. Epub 2006 Sep 20.

PMID:
16987932
20.

Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.

Li JG, Barrero C, Gupta S, Kruger WD, Merali S, Praticò D.

Aging Cell. 2017 Apr;16(2):273-280. doi: 10.1111/acel.12550. Epub 2016 Nov 29.

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