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Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.

So JY, Smolarek AK, Salerno DM, Maehr H, Uskokovic M, Liu F, Suh N.

PLoS One. 2013;8(1):e54020. doi: 10.1371/journal.pone.0054020. Epub 2013 Jan 11.


HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.

So JY, Wahler J, Das Gupta S, Salerno DM, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2015 Apr;148:111-21. doi: 10.1016/j.jsbmb.2014.12.013. Epub 2014 Dec 23.


A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.

So JY, Lee HJ, Smolarek AK, Paul S, Wang CX, Maehr H, Uskokovic M, Zheng X, Conney AH, Cai L, Liu F, Suh N.

Mol Pharmacol. 2011 Mar;79(3):360-7. doi: 10.1124/mol.110.068403. Epub 2010 Nov 29.


Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.

Lee HJ, So JY, DeCastro A, Smolarek A, Paul S, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):408-12. doi: 10.1016/j.jsbmb.2010.03.053. Epub 2010 Mar 19.


Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.

Wahler J, So JY, Kim YC, Liu F, Maehr H, Uskokovic M, Suh N.

Cancer Prev Res (Phila). 2014 Jun;7(6):617-26. doi: 10.1158/1940-6207.CAPR-13-0362. Epub 2014 Apr 1.


CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity.

Montgomery N, Hill A, McFarlane S, Neisen J, O'Grady A, Conlon S, Jirstrom K, Kay EW, Waugh DJ.

Breast Cancer Res. 2012 May 23;14(3):R84.


Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer.

Wahler J, So JY, Cheng LC, Maehr H, Uskokovic M, Suh N.

J Steroid Biochem Mol Biol. 2015 Apr;148:148-55. doi: 10.1016/j.jsbmb.2014.10.016. Epub 2014 Oct 31.


Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells.

Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J.

PLoS One. 2013 Dec 23;8(12):e82821. doi: 10.1371/journal.pone.0082821. eCollection 2013.


Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.

Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N.

Cancer Prev Res (Phila). 2008 Nov;1(6):476-84. doi: 10.1158/1940-6207.CAPR-08-0084.


The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.

Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K.

J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745.


Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells.

Chung SS, Aroh C, Vadgama JV.

PLoS One. 2013 Dec 30;8(12):e83971. doi: 10.1371/journal.pone.0083971. eCollection 2013.


Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer.

Lee HJ, Liu H, Goodman C, Ji Y, Maehr H, Uskokovic M, Notterman D, Reiss M, Suh N.

Biochem Pharmacol. 2006 Jul 28;72(3):332-43. Epub 2006 May 5.


Small molecule 1'-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway.

Wang J, Zhang L, Chen G, Zhang J, Li Z, Lu W, Liu M, Pang X.

Breast Cancer Res Treat. 2014 Nov;148(2):279-89. doi: 10.1007/s10549-014-3165-6. Epub 2014 Oct 10.


Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis.

Liu F, Zhang H, Song H.

Oncol Rep. 2017 Jan;37(1):83-90. doi: 10.3892/or.2016.5256. Epub 2016 Nov 18.


Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy.

Pervin S, Hewison M, Braga M, Tran L, Chun R, Karam A, Chaudhuri G, Norris K, Singh R.

PLoS One. 2013;8(1):e53287. doi: 10.1371/journal.pone.0053287. Epub 2013 Jan 14. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/5326d117-3f31-4e43-a5c4-9e1fb41719e9.


Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44.

Mandal CC, Ghosh-Choudhury N, Yoneda T, Choudhury GG, Ghosh-Choudhury N.

J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.


Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer cells.

Kim S, Kil WH, Lee J, Oh SJ, Han J, Jeon M, Jung T, Lee SK, Bae SY, Lee HC, Lee JH, Yi HW, Kim SW, Nam SJ, Lee JE.

Oncol Rep. 2014 Dec;32(6):2666-72. doi: 10.3892/or.2014.3514. Epub 2014 Sep 24.


CD44 enhances the epithelial-mesenchymal transition in association with colon cancer invasion.

Cho SH, Park YS, Kim HJ, Kim CH, Lim SW, Huh JW, Lee JH, Kim HR.

Int J Oncol. 2012 Jul;41(1):211-8. doi: 10.3892/ijo.2012.1453. Epub 2012 Apr 30.


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