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Items: 1 to 20 of 75

1.

Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

Terman DS, Viglianti BL, Zennadi R, Fels D, Boruta RJ, Yuan H, Dreher MR, Grant G, Rabbani ZN, Moon E, Lan L, Eble J, Cao Y, Sorg B, Ashcraft K, Palmer G, Telen MJ, Dewhirst MW.

PLoS One. 2013;8(1):e52543. doi: 10.1371/journal.pone.0052543. Epub 2013 Jan 9.

2.

Drug-loaded sickle cells programmed ex vivo for delayed hemolysis target hypoxic tumor microvessels and augment tumor drug delivery.

Choe SW, Terman DS, Rivers AE, Rivera J, Lottenberg R, Sorg BS.

J Control Release. 2013 Oct 28;171(2):184-92. doi: 10.1016/j.jconrel.2013.07.008. Epub 2013 Jul 18.

3.

Sickle cells produce functional immune modulators and cytotoxics.

Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T, Terman DS.

Am J Hematol. 2017 Oct;92(10):981-988. doi: 10.1002/ajh.24836. Epub 2017 Aug 17.

PMID:
28646491
4.

Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo.

Sun CW, Willmon C, Wu LC, Knopick P, Thoerner J, Vile R, Townes TM, Terman DS.

Front Oncol. 2016 Jul 8;6:166. doi: 10.3389/fonc.2016.00166. eCollection 2016.

5.

Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin.

Liu YS, Li HS, Qi DF, Zhang J, Jiang XC, Shi K, Zhang XJ, Zhang XH.

World J Gastroenterol. 2014 Jul 14;20(26):8572-82. doi: 10.3748/wjg.v20.i26.8572.

6.

Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice.

Nowis D, Bugajski M, Winiarska M, Bil J, Szokalska A, Salwa P, Issat T, Was H, Jozkowicz A, Dulak J, Stoklosa T, Golab J.

BMC Cancer. 2008 Jul 11;8:197. doi: 10.1186/1471-2407-8-197.

7.
8.

Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment.

Sun X, Ackerstaff E, He F, Xing L, Hsiao HT, Koutcher JA, Ling CC, Li GC.

Oncotarget. 2015 Oct 27;6(33):34732-44. doi: 10.18632/oncotarget.5300.

9.

Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice.

Belcher JD, Mahaseth H, Welch TE, Otterbein LE, Hebbel RP, Vercellotti GM.

J Clin Invest. 2006 Mar;116(3):808-16. Epub 2006 Feb 16.

10.

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.

Stegeman H, Kaanders JH, Wheeler DL, van der Kogel AJ, Verheijen MM, Waaijer SJ, Iida M, Grénman R, Span PN, Bussink J.

BMC Cancer. 2012 Oct 10;12:463. doi: 10.1186/1471-2407-12-463.

11.
12.

MEK1/2 inhibitors reverse acute vascular occlusion in mouse models of sickle cell disease.

Zhao Y, Schwartz EA, Palmer GM, Zennadi R.

FASEB J. 2016 Mar;30(3):1171-86. doi: 10.1096/fj.15-278481. Epub 2015 Nov 30.

13.

Solid tumors "melt" from the inside after successful CD8 T cell attack.

Blohm U, Potthoff D, van der Kogel AJ, Pircher H.

Eur J Immunol. 2006 Feb;36(2):468-77.

14.

Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide.

Barsoum IB, Hamilton TK, Li X, Cotechini T, Miles EA, Siemens DR, Graham CH.

Cancer Res. 2011 Dec 15;71(24):7433-41. doi: 10.1158/0008-5472.CAN-11-2104. Epub 2011 Oct 17. Erratum in: Cancer Res. 2012 Feb 1;72(3):827.

15.

Heme degradation and vascular injury.

Belcher JD, Beckman JD, Balla G, Balla J, Vercellotti G.

Antioxid Redox Signal. 2010 Feb;12(2):233-48. doi: 10.1089/ars.2009.2822. Review.

16.

Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages.

Vishvakarma NK, Singh SM.

Immunol Lett. 2010 Nov 30;134(1):83-92. doi: 10.1016/j.imlet.2010.09.002. Epub 2010 Sep 15.

PMID:
20837061
17.

Role of hemin in the modulation of H2O2-mediated endothelial cell injury.

Wilson SJ, Keenan AK.

Vascul Pharmacol. 2003 Feb;40(2):109-18.

PMID:
12646399
18.

Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/β-catenin signaling pathway.

Wang S, Avery JE, Hannafon BN, Lind SE, Ding WQ.

Biochem Pharmacol. 2013 Jun 1;85(11):1611-8. doi: 10.1016/j.bcp.2013.03.011. Epub 2013 Mar 21.

PMID:
23523860
19.

Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation.

Iyer AK, Greish K, Seki T, Okazaki S, Fang J, Takeshita K, Maeda H.

J Drug Target. 2007 Aug-Sep;15(7-8):496-506.

PMID:
17671896
20.

Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity.

Sahoo SK, Sawa T, Fang J, Tanaka S, Miyamoto Y, Akaike T, Maeda H.

Bioconjug Chem. 2002 Sep-Oct;13(5):1031-8.

PMID:
12236785

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