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HER2 stabilizes survivin while concomitantly down-regulating survivin gene transcription by suppressing Notch cleavage.

Ju JH, Yang W, Oh S, Nam K, Lee KM, Noh DY, Shin I.

Biochem J. 2013 Apr 1;451(1):123-34. doi: 10.1042/BJ20121716.


Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex.

Arora V, Cheung HH, Plenchette S, Micali OC, Liston P, Korneluk RG.

J Biol Chem. 2007 Sep 7;282(36):26202-9. Epub 2007 Jul 5.


Roles of BIM induction and survivin downregulation in lapatinib-induced apoptosis in breast cancer cells with HER2 amplification.

Tanizaki J, Okamoto I, Fumita S, Okamoto W, Nishio K, Nakagawa K.

Oncogene. 2011 Sep 29;30(39):4097-106. doi: 10.1038/onc.2011.111. Epub 2011 Apr 18.


Survivin regulation by HER2 through NF-κB and c-myc in irradiated breast cancer cells.

Papanikolaou V, Iliopoulos D, Dimou I, Dubos S, Kappas C, Kitsiou-Tzeli S, Tsezou A.

J Cell Mol Med. 2011 Jul;15(7):1542-50. doi: 10.1111/j.1582-4934.2010.01149.x.


Enhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex.

Kim KS, Heo JI, Choi KJ, Bae S.

Cancer Biol Ther. 2014;15(12):1622-34. doi: 10.4161/15384047.2014.962305.


Wogonin induces apoptosis and down-regulates survivin in human breast cancer MCF-7 cells by modulating PI3K-AKT pathway.

Huang KF, Zhang GD, Huang YQ, Diao Y.

Int Immunopharmacol. 2012 Feb;12(2):334-41. doi: 10.1016/j.intimp.2011.12.004. Epub 2011 Dec 17.


STAT3-survivin signaling mediates a poor response to radiotherapy in HER2-positive breast cancers.

Kim JS, Kim HA, Seong MK, Seol H, Oh JS, Kim EK, Chang JW, Hwang SG, Noh WC.

Oncotarget. 2016 Feb 9;7(6):7055-65. doi: 10.18632/oncotarget.6855.


XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer.

Yu LF, Wang J, Zou B, Lin MC, Wu YL, Xia HH, Sun YW, Gu Q, He H, Lam SK, Kung HF, Wong BC.

Cancer. 2007 May 15;109(10):1996-2003.


Down-regulation of Notch receptor signaling pathway induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells.

Cao H, Hu Y, Wang P, Zhou J, Deng Z, Wen J.

APMIS. 2012 Jun;120(6):441-50. doi: 10.1111/j.1600-0463.2011.02825.x. Epub 2012 Apr 4.


Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing, estrogen receptor-positive breast cancer cells.

Sengupta S, Schiff R, Katzenellenbogen BS.

Breast Cancer Res Treat. 2009 Sep;117(2):243-51. doi: 10.1007/s10549-008-0186-z. Epub 2008 Sep 19.


X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis.

Cao Z, Zhang R, Li J, Huang H, Zhang D, Zhang J, Gao J, Chen J, Huang C.

J Biol Chem. 2013 Jul 12;288(28):20238-47. doi: 10.1074/jbc.M112.448365. Epub 2013 May 29.


Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK.

Cancer Res. 2010 Mar 15;70(6):2476-84. doi: 10.1158/0008-5472.CAN-09-3114. Epub 2010 Mar 2.


Down regulation of CSL activity inhibits cell proliferation in prostate and breast cancer cells.

Yong T, Sun A, Henry MD, Meyers S, Davis JN.

J Cell Biochem. 2011 Sep;112(9):2340-51. doi: 10.1002/jcb.23157.


The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells.

Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG.

Blood. 2008 Jan 15;111(2):846-55. Epub 2007 Oct 10.


XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.

Lee MG, Han J, Jeong SI, Her NG, Lee JH, Ha TK, Kang MJ, Ryu BK, Chi SG.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15532-7. doi: 10.1073/pnas.1411746111. Epub 2014 Oct 13.

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