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Items: 1 to 20 of 45

1.

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.

Wu J, Zhang D, Chen L, Li J, Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, Chen K, Jiang H, Liu H, Liu D.

J Med Chem. 2013 Feb 14;56(3):761-80. doi: 10.1021/jm301032j. Epub 2013 Jan 28.

PMID:
23316803
2.

A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.

Feng Y, Wu J, Chen L, Luo C, Shen X, Chen K, Jiang H, Liu D.

Anal Biochem. 2009 Dec 15;395(2):205-10. doi: 10.1016/j.ab.2009.08.011. Epub 2009 Aug 13.

PMID:
19682970
3.

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol.

Cao D, Wang M, Qiu X, Liu D, Jiang H, Yang N, Xu RM.

Genes Dev. 2015 Jun 15;29(12):1316-25. doi: 10.1101/gad.265462.115.

4.

Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.

Nguyen GT, Gertz M, Steegborn C.

Chem Biol. 2013 Nov 21;20(11):1375-85. doi: 10.1016/j.chembiol.2013.09.019. Epub 2013 Nov 7.

5.

Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging.

Wang Y, Chen Y, Wang H, Cheng Y, Zhao X.

Anal Chem. 2015;87(10):5046-9. doi: 10.1021/acs.analchem.5b01069. Epub 2015 Apr 27.

PMID:
25903518
6.

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.

7.

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.

Chen L, Feng Y, Zhou Y, Zhu W, Shen X, Chen K, Jiang H, Liu D.

J Inorg Biochem. 2010 Feb;104(2):180-5. doi: 10.1016/j.jinorgbio.2009.10.021. Epub 2009 Oct 29.

PMID:
19923004
8.

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.

Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG.

J Med Chem. 2013 Feb 14;56(3):963-9. doi: 10.1021/jm301431y. Epub 2013 Jan 29. Erratum in: J Med Chem. 2016 Mar 10;59(5):2267.

PMID:
23311358
9.

Ligand and structure-based approaches for the identification of SIRT1 activators.

Vyas VK, Goel A, Ghate M, Patel P.

Chem Biol Interact. 2015 Feb 25;228:9-17. doi: 10.1016/j.cbi.2015.01.001. Epub 2015 Jan 13.

PMID:
25595223
10.

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C.

PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21.

11.

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.

Huhtiniemi T, Salo HS, Suuronen T, Poso A, Salminen A, Leppänen J, Jarho E, Lahtela-Kakkonen M.

J Med Chem. 2011 Oct 13;54(19):6456-68. doi: 10.1021/jm200590k. Epub 2011 Sep 7.

PMID:
21895016
12.

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483. Epub 2010 Mar 4.

13.

Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.

Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K.

Mol Biosyst. 2011 Jan;7(1):59-66. doi: 10.1039/c0mb00026d. Epub 2010 Oct 8.

PMID:
20931131
14.

Sirtuin 1 (SIRT1): the misunderstood HDAC.

Stünkel W, Campbell RM.

J Biomol Screen. 2011 Dec;16(10):1153-69. doi: 10.1177/1087057111422103. Epub 2011 Nov 15. Review.

PMID:
22086720
15.

Structural and functional analysis of human SIRT1.

Davenport AM, Huber FM, Hoelz A.

J Mol Biol. 2014 Feb 6;426(3):526-41. doi: 10.1016/j.jmb.2013.10.009. Epub 2013 Oct 10.

16.

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.

J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954.

PMID:
19199480
17.

Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.

Nogalska A, D'Agostino C, Engel WK, Davies KJ, Askanas V.

Neurobiol Aging. 2010 Sep;31(9):1637-48. doi: 10.1016/j.neurobiolaging.2008.08.021. Epub 2008 Oct 14.

PMID:
18922603
18.

Comparative deacetylase activity of wild type and mutants of SIRT1.

Malik R, Kashyap A, Bansal K, Sharma P, Rayasam GV, Davis JA, Bora RS, Ray A, Saini KS.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):739-43. doi: 10.1016/j.bbrc.2009.11.130. Epub 2009 Nov 26.

PMID:
19944070
19.

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

Disch JS, Evindar G, Chiu CH, Blum CA, Dai H, Jin L, Schuman E, Lind KE, Belyanskaya SL, Deng J, Coppo F, Aquilani L, Graybill TL, Cuozzo JW, Lavu S, Mao C, Vlasuk GP, Perni RB.

J Med Chem. 2013 May 9;56(9):3666-79. doi: 10.1021/jm400204k. Epub 2013 Apr 29.

PMID:
23570514
20.

High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay.

Liu Y, Gerber R, Wu J, Tsuruda T, McCarter JD.

Anal Biochem. 2008 Jul 1;378(1):53-9. doi: 10.1016/j.ab.2008.02.018. Epub 2008 Mar 4.

PMID:
18358225

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