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Increased expression of senescence markers in cystic fibrosis airways.

Fischer BM, Wong JK, Degan S, Kummarapurugu AB, Zheng S, Haridass P, Voynow JA.

Am J Physiol Lung Cell Mol Physiol. 2013 Mar 15;304(6):L394-400. doi: 10.1152/ajplung.00091.2012. Epub 2013 Jan 11.


Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC.

Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13742-7.


p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.

Sandhu C, Peehl DM, Slingerland J.

Cancer Res. 2000 May 15;60(10):2616-22.


Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.

Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, Wright WE, Shay JW.

Oncogene. 2003 Jan 23;22(3):433-44.


Differential epithelial expression of the putative innate immune molecule SPLUNC1 in cystic fibrosis.

Bingle L, Barnes FA, Cross SS, Rassl D, Wallace WA, Campos MA, Bingle CD.

Respir Res. 2007 Nov 7;8:79.


Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.

Garratt LW, Sutanto EN, Ling KM, Looi K, Iosifidis T, Martinovich KM, Shaw NC, Buckley AG, Kicic-Starcevich E, Lannigan FJ, Knight DA, Stick SM, Kicic A; Australian Respiratory Early Surveillance Team for Cystic Fibrosis.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):341-9. doi: 10.1165/rcmb.2015-0074OC.


Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.

Fischer BM, Zheng S, Fan R, Voynow JA.

Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L762-8. Epub 2007 Jun 22.


Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis.

Ruffin M, Voland M, Marie S, Bonora M, Blanchard E, Blouquit-Laye S, Naline E, Puyo P, Le Rouzic P, Guillot L, Corvol H, Clement A, Tabary O.

Biochim Biophys Acta. 2013 Dec;1832(12):2340-51. doi: 10.1016/j.bbadis.2013.09.012. Epub 2013 Sep 27.


Fluticasone reduces IL-6 and IL-8 production of cystic fibrosis bronchial epithelial cells via IKK-beta kinase pathway.

Escotte S, Tabary O, Dusser D, Majer-Teboul C, Puchelle E, Jacquot J.

Eur Respir J. 2003 Apr;21(4):574-81.


Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence: roles of p16, p21, and cyclin D1.

Morisaki H, Ando A, Nagata Y, Pereira-Smith O, Smith JR, Ikeda K, Nakanishi M.

Exp Cell Res. 1999 Dec 15;253(2):503-10.


Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.

Brookes S, Gagrica S, Sanij E, Rowe J, Gregory FJ, Hara E, Peters G.

Cell Cycle. 2015;14(8):1164-73. doi: 10.1080/15384101.2015.1010866.


A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.

Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM.

Mol Cell Biol. 2002 Jul;22(14):5157-72.


CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.

Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G.

Mol Cell Biol. 2007 Jun;27(12):4273-82. Epub 2007 Apr 9.


H3K9me-enhanced DNA hypermethylation of the p16INK4a gene: an epigenetic signature for spontaneous transformation of rat mesenchymal stem cells.

Zheng Y, He L, Wan Y, Song J.

Stem Cells Dev. 2013 Jan 15;22(2):256-67. doi: 10.1089/scd.2012.0172. Epub 2012 Nov 7.


Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.


Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.).

Sasaki M, Kajiya H, Ozeki S, Okabe K, Ikebe T.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):622-8. doi: 10.1016/j.bbrc.2014.08.123. Epub 2014 Aug 30.


Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.

Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.

Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC.


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