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Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation.

Lapkouski M, Tian L, Miller JT, Le Grice SFJ, Yang W.

Nat Struct Mol Biol. 2013 Feb;20(2):230-236. doi: 10.1038/nsmb.2485. Epub 2013 Jan 13.


Structural requirements for RNA degradation by HIV-1 reverse transcriptase.

Das K, Sarafianos SG, Arnold E.

Nat Struct Mol Biol. 2013 Dec;20(12):1341-2. doi: 10.1038/nsmb.2725. No abstract available.


Reply to "Structural requirements for RNA degradation by HIV-1 reverse transcriptase".

Lapkouski M, Tian L, Miller JT, Le Grice SF, Yang W.

Nat Struct Mol Biol. 2013 Dec;20(12):1342-3. doi: 10.1038/nsmb.2726. No abstract available.


Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase.

Patel PH, Jacobo-Molina A, Ding J, Tantillo C, Clark AD Jr, Raag R, Nanni RG, Hughes SH, Arnold E.

Biochemistry. 1995 Apr 25;34(16):5351-63.


Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.

Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E.

J Mol Biol. 1996 Dec 20;264(5):1085-100.


Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.

Li TK, Barbieri CM, Lin HC, Rabson AB, Yang G, Fan Y, Gaffney BL, Jones RA, Pilch DS.

Biochemistry. 2004 Aug 3;43(30):9732-42.


Molecular modeling studies of HIV-1 reverse transcriptase nonnucleoside inhibitors: total energy of complexation as a predictor of drug placement and activity.

Kroeger Smith MB, Rouzer CA, Taneyhill LA, Smith NA, Hughes SH, Boyer PL, Janssen PA, Moereels H, Koymans L, Arnold E, et al.

Protein Sci. 1995 Oct;4(10):2203-22.


Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids.

Wöhrl BM, Moelling K.

Biochemistry. 1990 Nov 6;29(44):10141-7.


HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.

Das K, Arnold E.

Curr Opin Virol. 2013 Apr;3(2):119-28. doi: 10.1016/j.coviro.2013.03.014. Epub 2013 Apr 19. Review.


Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Das K, Martinez SE, Bandwar RP, Arnold E.

Nucleic Acids Res. 2014 Jul;42(12):8125-37. doi: 10.1093/nar/gku487. Epub 2014 May 31.


The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.

Ren J, Esnouf R, Hopkins A, Ross C, Jones Y, Stammers D, Stuart D.

Structure. 1995 Sep 15;3(9):915-26.


Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.

Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, Pauwels R, Andries K, Janssen PA, Arnold E.

J Mol Biol. 1994 Oct 28;243(3):369-87. Review.


Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E.

Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Aristoff PA, Tarpley WG, Reusser F.

J Biol Chem. 1993 Mar 25;268(9):6119-24.


Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

Vijayan RS, Arnold E, Das K.

Proteins. 2014 May;82(5):815-29. doi: 10.1002/prot.24460. Epub 2013 Nov 22.


Examining the role of the HIV-1 reverse transcriptase p51 subunit in positioning and hydrolysis of RNA/DNA hybrids.

Chung S, Miller JT, Lapkouski M, Tian L, Yang W, Le Grice SF.

J Biol Chem. 2013 May 31;288(22):16177-84. doi: 10.1074/jbc.M113.465641. Epub 2013 Apr 17.


Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097.

Das K, Sarafianos SG, Clark AD Jr, Boyer PL, Hughes SH, Arnold E.

J Mol Biol. 2007 Jan 5;365(1):77-89. Epub 2006 Sep 15.


Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription.

Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W.

Mol Cell. 2007 Oct 26;28(2):264-76. Erratum in: Mol Cell. 2007 Nov 9;28(3):513.

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