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23313283,29482068,21256255,28474171,10512321,12929928,11028442,22508505,17573250,23951127,32325250,28821457,9101370,17627087,14606513,30545382,25614341,16759917,9200005,31355449,15542029,17160577,16007339,21940137,9600760,18269310,17550335,28017615,27171384,11918215,20157807,17295603,11000349,11149481,26315408,12200652,24780610,16427371,12439222,18478952,24496638,15037970,25596521,17010133,18198010,20870046,12115066,12817748,25492928,24558108,25445447,16418783,17980998,16340452,19874182,17705049,11450694,10742449,22080166,15005847,8592951,17551766,17164974,10913633,24125756,25241982,33068139,15997422,18465074,24011361,15765183,18164699,17451375,17361010,17708715,23890357,15746986,26138460,23017660,18348690,13678781,35654351,25713355,32896553,23810710,24204923,26173414,11792574,32446379,26343450,17888748,25781979,16984642,22451246,9737340,35439425,36465647,15569633,21533960,29635039,16731065,25661670,26852895,30721697,26801156,26076041,31307226,18801900,17127431,25163478,15297744,23616150,10068090,21722764,14555251,26374466,22714552,24753072,29720540,28013361,28582728,28532411,16404140,24930774,28369124,27528549,16289987,27844403,21458604,27318466,11415824,10511108,26123128,26488807,20515806,27401043,25646711,18303182,27669658,10511107,33925003,16404141,35718803,28928054,26272319,12110418,27113526,27605453,20876238,14623052,29677191,25724145,26572927,25389287,26374841,17965556,10673112,33294500,8875702,37065630,28431562,10071908,23431208,9496233,32140062,24743108,35718927,28060768,25872143,20117029,35318866,26580614,30939949,22002813,26860048,10962358,23106910,28056995,27178020,9600789,28177139,25005697,10846003,15362035,3248203,28388781,34626249,21447924,25785491,23194305,30375985,22970183,21928431,27191548,18769962,16875891,25521583,25189426,32002681,33527352,31444374,29175269,26230337,29438824,27999894,25943007,24382882,18282131,30857427,9701466,17878319,9124325,29088267,9489773,15000262,17878629,1389569,17344109,31991250,24663486,27189961,31140414,29618611,23900689,29154456,27355188,22514696,26546009,11149483,28902435,36883194,17848159,32778234,29199192,21526395,33964862,31678497,20499381,21372431,12627301,11062347,12793765,31072650,27230741,27711209,1592854,22624037,12702215,33662519,28161898,29575561,27004741,25451322,29651717,23359245,29754047,7484370,29530924,21328564,28828965,22234945,25957113,26017218,23247008,7796349,28956370,15348250,18221861,36054133,16610557,29931945,28163158,28236102,29276733,2719732,15308820,31521827,21757756,30388359,20458604,25799494,18396127,31262364,22644324,30094297,24838643,34878660,1571835,32911224,7328488,30357817,31437568,28526286,19619411,27384302,30012927,25645569,27486705,30377814,34688315,1415691,21915988,28982680,22160436,31148574,12531560,36005143,31768488,25690167,19949279,20107848,20937421,32037388,23389860,30588298,34289176,33822263,23117208,34637435,30922120,35309863,33962613,32435691,34347076,29133259,34632005,36743287,18703871,34389472,31596925,31846076,36685194,30913317,29963600,28056959,34467429,22840776,32094386,3964496,35704049,35273515,34306112,21241467,29411354,22770664,25003813,30294717,18522730,33396052,1910958,30712070,7772268,33207791,33065355,24422141,31341896,34725275,26749194,34099702,36771291,34978301,11351499,21296060,27087939,8763478,20503060,10348454,24583535,30950516,27471493,25917136,27350329,25051433,35711519,36808149,2943110,36989318,21276183,30044115,34973493,33050161,2765711,1606916,36979634,33392366,24440290,14851976,423513,29249928,35619053,31814831,28523251,29552329,3596264,12051303,25789256,19555488,27106103,35866150,33592122,26471755,627701,14855771,14816873,13220244,32514323,33060731,35991534,21432435,13902828,35207520,13333831,25019033,21969779,27252521,28597538,17509144,31546952,17342242,18129889,18903075,17233014,28011353,27866994[uid]

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Disruption of aldehyde dehydrogenase 2 gene results in altered cortical bone structure and increased cortical bone mineral density in the femoral diaphysis of mice.

Tsuchiya T, Sakai A, Menuki K, Mori T, Takeuchi Y, Kanoh S, Utsunomiya H, Murai T, Isse T, Kawamoto T, Nakamura T. Tsuchiya T, et al. Bone. 2013 Apr;53(2):358-68. doi: 10.1016/j.bone.2012.12.049. Epub 2013 Jan 10. Bone. 2013. PMID: 23313283

Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes.

Tajima T, Menuki K, Okuma KF, Tsukamoto M, Fukuda H, Okada Y, Kosugi K, Yamanaka Y, Uchida S, Sakai A. Tajima T, et al. Bone. 2018 May;110:254-266. doi: 10.1016/j.bone.2018.02.020. Epub 2018 Feb 23. Bone. 2018. PMID: 29482068

Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice.

Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T. Shimizu Y, et al. Bone. 2011 May 1;48(5):1075-86. doi: 10.1016/j.bone.2011.01.008. Epub 2011 Jan 20. Bone. 2011. PMID: 21256255

Disruption of the Aldehyde Dehydrogenase 2 Gene Results in No Increase in Trabecular Bone Mass Due to Skeletal Loading in Association with Impaired Cell Cycle Regulation Through p21 Expression in the Bone Marrow Cells of Mice.

Okuma KF, Menuki K, Tsukamoto M, Tajima T, Fukuda H, Okada Y, Mori T, Tsuchiya T, Kawamoto T, Yoshida Y, Uchida S, Sakai A. Okuma KF, et al. Calcif Tissue Int. 2017 Sep;101(3):328-340. doi: 10.1007/s00223-017-0285-0. Epub 2017 May 4. Calcif Tissue Int. 2017. PMID: 28474171 Free PMC article.

Chronic alcohol consumption during male rat adolescence impairs skeletal development through effects on osteoblast gene expression, bone mineral density, and bone strength.

Wezeman FH, Emanuele MA, Emanuele NV, Moskal SF 2nd, Woods M, Suri M, Steiner J, LaPaglia N. Wezeman FH, et al. Alcohol Clin Exp Res. 1999 Sep;23(9):1534-42. Alcohol Clin Exp Res. 1999. PMID: 10512321

Osteoblast-specific targeting of soluble colony-stimulating factor-1 increases cortical bone thickness in mice.

Abboud SL, Ghosh-Choudhury N, Liu LC, Shen V, Woodruff K. Abboud SL, et al. J Bone Miner Res. 2003 Aug;18(8):1386-94. doi: 10.1359/jbmr.2003.18.8.1386. J Bone Miner Res. 2003. PMID: 12929928 Free article.

Mineral density and bone strength are dissociated in long bones of rat osteopetrotic mutations.

Tuukkanen J, Koivukangas A, Jämsä T, Sundquist K, Mackay CA, Marks SC Jr. Tuukkanen J, et al. J Bone Miner Res. 2000 Oct;15(10):1905-11. doi: 10.1359/jbmr.2000.15.10.1905. J Bone Miner Res. 2000. PMID: 11028442 Free article.

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis.

Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H, Matsumoto M, Chiba K, Toyama Y, Miyamoto T. Hoshi H, et al. J Bone Miner Res. 2012 Sep;27(9):2015-23. doi: 10.1002/jbmr.1634. J Bone Miner Res. 2012. PMID: 22508505 Free article.

Effects of daily treatment with parathyroid hormone 1-84 for 16 months on density, architecture and biomechanical properties of cortical bone in adult ovariectomized rhesus monkeys.

Fox J, Miller MA, Newman MK, Recker RR, Turner CH, Smith SY. Fox J, et al. Bone. 2007 Sep;41(3):321-30. doi: 10.1016/j.bone.2007.04.197. Epub 2007 May 13. Bone. 2007. PMID: 17573250

Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo.

Nallamshetty S, Wang H, Rhee EJ, Kiefer FW, Brown JD, Lotinun S, Le P, Baron R, Rosen CJ, Plutzky J. Nallamshetty S, et al. PLoS One. 2013 Aug 9;8(8):e71307. doi: 10.1371/journal.pone.0071307. eCollection 2013. PLoS One. 2013. PMID: 23951127 Free PMC article.

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