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Items: 1 to 20 of 200

1.

Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.

Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE.

Mol Pharmacol. 2013 Apr;83(4):781-92. doi: 10.1124/mol.112.083477. Epub 2013 Jan 10. Erratum in: Mol Pharmacol. 2013 Sep;84(3):487. Hamm, Heidi [corrected to Hamm, Heidi E].

2.

Platelet protease-activated receptor (PAR)4, but not PAR1, associated with neutral sphingomyelinase responsible for thrombin-stimulated ceramide-NF-κB signaling in human platelets.

Chen WF, Lee JJ, Chang CC, Lin KH, Wang SH, Sheu JR.

Haematologica. 2013 May;98(5):793-801. doi: 10.3324/haematol.2012.072553. Epub 2012 Oct 12.

3.

Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway.

Holinstat M, Voss B, Bilodeau ML, Hamm HE.

Mol Pharmacol. 2007 Mar;71(3):686-94. Epub 2006 Dec 6. Erratum in: Mol Pharmacol. 2009 Mar;75(3):730-1.

4.

Protease-activating receptor-4 induces full platelet spreading on a fibrinogen matrix: involvement of ERK2 and p38 and Ca2+ mobilization.

Mazharian A, Roger S, Berrou E, Adam F, Kauskot A, Nurden P, Jandrot-Perrus M, Bryckaert M.

J Biol Chem. 2007 Feb 23;282(8):5478-87. Epub 2007 Jan 2.

5.

[Role of adenosine diphosphate in the course of thrombin signal transmission].

Han Y, Lu XX, Wang ZY, Dai L, Shen WH, Wu DP, Ruan CG.

Zhonghua Yi Xue Za Zhi. 2006 Dec 12;86(46):3299-301. Chinese.

PMID:
17313817
6.

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.

Carrim N, Arthur JF, Hamilton JR, Gardiner EE, Andrews RK, Moran N, Berndt MC, Metharom P.

Redox Biol. 2015 Dec;6:640-7. doi: 10.1016/j.redox.2015.10.009. Epub 2015 Oct 28.

7.
8.

Protease-activated receptor-induced Akt activation--regulation and possible function.

Reséndiz JC, Kroll MH, Lassila R.

J Thromb Haemost. 2007 Dec;5(12):2484-93. Epub 2007 Sep 19.

9.

The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine.

Grenegård M, Vretenbrant-Oberg K, Nylander M, Désilets S, Lindström EG, Larsson A, Ramström I, Ramström S, Lindahl TL.

J Biol Chem. 2008 Jul 4;283(27):18493-504. doi: 10.1074/jbc.M800358200. Epub 2008 May 14.

10.

The role of PAR4 in thrombin-induced thromboxane production in human platelets.

Wu CC, Hwang TL, Liao CH, Kuo SC, Lee FY, Teng CM.

Thromb Haemost. 2003 Aug;90(2):299-308.

PMID:
12888878
11.

PAR1-stimulated platelet releasate promotes angiogenic activities of endothelial progenitor cells more potently than PAR4-stimulated platelet releasate.

Huang Z, Miao X, Luan Y, Zhu L, Kong F, Lu Q, Pernow J, Nilsson G, Li N.

J Thromb Haemost. 2015 Mar;13(3):465-76. doi: 10.1111/jth.12815. Epub 2015 Jan 31.

12.

Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions.

Hosokawa K, Ohnishi T, Miura N, Sameshima H, Koide T, Tanaka KA, Maruyama I.

Thromb Res. 2014 Jan;133(1):66-72. doi: 10.1016/j.thromres.2013.10.037. Epub 2013 Oct 31.

PMID:
24268424
13.

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.

French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR.

J Thromb Haemost. 2016 Aug;14(8):1642-54. doi: 10.1111/jth.13293. Epub 2016 Jun 22.

PMID:
26878340
14.

Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets.

Covic L, Gresser AL, Kuliopulos A.

Biochemistry. 2000 May 9;39(18):5458-67.

PMID:
10820018
15.

Role of protease-activated and ADP receptor subtypes in thrombin generation on human platelets.

Dorsam RT, Tuluc M, Kunapuli SP.

J Thromb Haemost. 2004 May;2(5):804-12.

16.

Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets.

Fälker K, Haglund L, Gunnarsson P, Nylander M, Lindahl TL, Grenegård M.

Biochem J. 2011 Jun 1;436(2):469-80. doi: 10.1042/BJ20101360.

PMID:
21391917
17.

Platelet activation via PAR4 is involved in the initiation of thrombin generation and in clot elasticity development.

Vretenbrant K, Ramström S, Bjerke M, Lindahl TL.

Thromb Haemost. 2007 Mar;97(3):417-24.

PMID:
17334509
18.

PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact.

Judge HM, Jennings LK, Moliterno DJ, Hord E, Ecob R, Tricoci P, Rorick T, Kotha J, Storey RF.

Platelets. 2015;26(3):236-42. doi: 10.3109/09537104.2014.902924. Epub 2014 Apr 21.

PMID:
24750101
19.

The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets.

Nylander M, Osman A, Ramström S, Aklint E, Larsson A, Lindahl TL.

Thromb Res. 2012 Apr;129(4):e51-8. doi: 10.1016/j.thromres.2011.12.021. Epub 2012 Jan 26.

PMID:
22283974
20.

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.

Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR.

J Clin Invest. 1999 Mar;103(6):879-87.

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