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Items: 1 to 20 of 142

1.

pH-triggered nanoparticle mediated delivery of siRNA to liver cells in vitro and in vivo.

Kolli S, Wong SP, Harbottle R, Johnston B, Thanou M, Miller AD.

Bioconjug Chem. 2013 Mar 20;24(3):314-32. doi: 10.1021/bc3004099. Epub 2013 Mar 7.

PMID:
23305315
2.

Controlling HBV replication in vivo by intravenous administration of triggered PEGylated siRNA-nanoparticles.

Carmona S, Jorgensen MR, Kolli S, Crowther C, Salazar FH, Marion PL, Fujino M, Natori Y, Thanou M, Arbuthnot P, Miller AD.

Mol Pharm. 2009 May-Jun;6(3):706-17. doi: 10.1021/mp800157x.

PMID:
19159285
3.

Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-L-lysine nanocarrier to suppress prostate cancer growth in mice.

Guo J, Cheng WP, Gu J, Ding C, Qu X, Yang Z, O'Driscoll C.

Eur J Pharm Sci. 2012 Apr 11;45(5):521-32. doi: 10.1016/j.ejps.2011.11.024. Epub 2011 Dec 11.

PMID:
22186295
4.

A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery.

Wang XL, Xu R, Lu ZR.

J Control Release. 2009 Mar 19;134(3):207-13. doi: 10.1016/j.jconrel.2008.11.010. Epub 2008 Nov 27.

PMID:
19135104
5.

Quantitation of physiological and biochemical barriers to siRNA liver delivery via lipid nanoparticle platform.

Xu Y, Ou M, Keough E, Roberts J, Koeplinger K, Lyman M, Fauty S, Carlini E, Stern M, Zhang R, Yeh S, Mahan E, Wang Y, Slaughter D, Gindy M, Raab C, Thompson C, Hochman J.

Mol Pharm. 2014 May 5;11(5):1424-34. doi: 10.1021/mp400584h. Epub 2014 Apr 1.

PMID:
24588618
6.

A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene therapy.

Ding Y, Wang W, Feng M, Wang Y, Zhou J, Ding X, Zhou X, Liu C, Wang R, Zhang Q.

Biomaterials. 2012 Dec;33(34):8893-905. doi: 10.1016/j.biomaterials.2012.08.057. Epub 2012 Sep 12.

PMID:
22979990
7.

Efficient delivery of Bcl-2-targeted siRNA using cationic polymer nanoparticles: downregulating mRNA expression level and sensitizing cancer cells to anticancer drug.

Beh CW, Seow WY, Wang Y, Zhang Y, Ong ZY, Ee PL, Yang YY.

Biomacromolecules. 2009 Jan 12;10(1):41-8. doi: 10.1021/bm801109g.

PMID:
19072631
8.

PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability.

Godinho BM, Ogier JR, Quinlan A, Darcy R, Griffin BT, Cryan JF, O'Driscoll CM.

Int J Pharm. 2014 Oct 1;473(1-2):105-12. doi: 10.1016/j.ijpharm.2014.06.054. Epub 2014 Jun 30.

PMID:
24992319
9.

Effect of PEGylation on biodistribution and gene silencing of siRNA/lipid nanoparticle complexes.

Bao Y, Jin Y, Chivukula P, Zhang J, Liu Y, Liu J, Clamme JP, Mahato RI, Ng D, Ying W, Wang Y, Yu L.

Pharm Res. 2013 Feb;30(2):342-51. doi: 10.1007/s11095-012-0874-6. Epub 2012 Sep 15.

PMID:
22983644
10.

The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery.

Zhang Y, Arrington L, Boardman D, Davis J, Xu Y, DiFelice K, Stirdivant S, Wang W, Budzik B, Bawiec J, Deng J, Beutner G, Seifried D, Stanton M, Gindy M, Leone A.

J Control Release. 2014 Jan 28;174:7-14. doi: 10.1016/j.jconrel.2013.11.006. Epub 2013 Nov 12.

PMID:
24240015
11.

Doping hydroxylated cationic lipid into PEGylated cerasome boosts in vivo siRNA transfection efficacy.

Li Y, Zheng S, Liang X, Jin Y, Wu Y, Bai H, Liu R, Dai Z, Liang Z, Shi T.

Bioconjug Chem. 2014 Nov 19;25(11):2055-66. doi: 10.1021/bc500414e. Epub 2014 Oct 10.

PMID:
25260060
12.

Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo.

Lin D, Cheng Q, Jiang Q, Huang Y, Yang Z, Han S, Zhao Y, Guo S, Liang Z, Dong A.

Nanoscale. 2013 May 21;5(10):4291-301. doi: 10.1039/c3nr00294b.

PMID:
23552843
13.

N-acetylgalactosamine functionalized mixed micellar nanoparticles for targeted delivery of siRNA to liver.

Wang HX, Xiong MH, Wang YC, Zhu J, Wang J.

J Control Release. 2013 Mar 10;166(2):106-14. doi: 10.1016/j.jconrel.2012.12.017. Epub 2012 Dec 20.

PMID:
23266452
14.

In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes.

Malek A, Merkel O, Fink L, Czubayko F, Kissel T, Aigner A.

Toxicol Appl Pharmacol. 2009 Apr 1;236(1):97-108. doi: 10.1016/j.taap.2009.01.014. Epub 2009 Jan 29.

PMID:
19371615
15.

Efficient siRNA delivery to mammalian cells using layered double hydroxide nanoparticles.

Ladewig K, Niebert M, Xu ZP, Gray PP, Lu GQ.

Biomaterials. 2010 Mar;31(7):1821-9. doi: 10.1016/j.biomaterials.2009.10.058. Epub 2009 Nov 17.

PMID:
19922997
16.

pH-responsive complexes using prefunctionalized polymers for synchronous delivery of doxorubicin and siRNA to cancer cells.

Dong DW, Xiang B, Gao W, Yang ZZ, Li JQ, Qi XR.

Biomaterials. 2013 Jul;34(20):4849-59. doi: 10.1016/j.biomaterials.2013.03.018. Epub 2013 Mar 27.

PMID:
23541420
17.

Reductively responsive siRNA-conjugated hydrogel nanoparticles for gene silencing.

Dunn SS, Tian S, Blake S, Wang J, Galloway AL, Murphy A, Pohlhaus PD, Rolland JP, Napier ME, DeSimone JM.

J Am Chem Soc. 2012 May 2;134(17):7423-30. doi: 10.1021/ja300174v. Epub 2012 Apr 19.

18.

Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery.

Shi B, Keough E, Matter A, Leander K, Young S, Carlini E, Sachs AB, Tao W, Abrams M, Howell B, Sepp-Lorenzino L.

J Histochem Cytochem. 2011 Aug;59(8):727-40. doi: 10.1369/0022155411410885.

19.

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

Heidel JD, Yu Z, Liu JY, Rele SM, Liang Y, Zeidan RK, Kornbrust DJ, Davis ME.

Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5715-21. Epub 2007 Mar 22.

20.

Enzyme-triggered PEGylated pDNA-nanoparticles for controlled release of pDNA in tumors.

Yingyuad P, Mével M, Prata C, Furegati S, Kontogiorgis C, Thanou M, Miller AD.

Bioconjug Chem. 2013 Mar 20;24(3):343-62. doi: 10.1021/bc300419g. Epub 2013 Feb 19.

PMID:
23305338

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