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Items: 1 to 20 of 97

1.

Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways.

Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ.

J Biol Chem. 2013 Feb 22;288(8):5398-406. doi: 10.1074/jbc.M112.413583. Epub 2013 Jan 7.

2.

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20764-9. doi: 10.1073/pnas.0805133106. Epub 2008 Dec 15.

3.

Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells.

Kong Y, Wang H, Lin T, Wang S.

Mediators Inflamm. 2014;2014:565369. doi: 10.1155/2014/565369. Epub 2014 Jul 23.

4.

G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase.

Takashima S, Sugimoto N, Takuwa N, Okamoto Y, Yoshioka K, Takamura M, Takata S, Kaneko S, Takuwa Y.

Cardiovasc Res. 2008 Sep 1;79(4):689-97. doi: 10.1093/cvr/cvn118. Epub 2008 May 14.

PMID:
18480127
5.

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo.

Ishii M, Kikuta J, Shimazu Y, Meier-Schellersheim M, Germain RN.

J Exp Med. 2010 Dec 20;207(13):2793-8. doi: 10.1084/jem.20101474. Epub 2010 Dec 6.

6.

Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells.

Li Q, Chen B, Zeng C, Fan A, Yuan Y, Guo X, Huang X, Huang Q.

Exp Physiol. 2015 Jan;100(1):95-107. doi: 10.1113/expphysiol.2014.082149. Epub 2014 Dec 2.

7.

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.

Ishii M, Egen JG, Klauschen F, Meier-Schellersheim M, Saeki Y, Vacher J, Proia RL, Germain RN.

Nature. 2009 Mar 26;458(7237):524-8. doi: 10.1038/nature07713. Epub 2009 Feb 8. Erratum in: Nature. 2010 Jun 17;465(7300):966.

8.

Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways.

Goyal P, Brünnert D, Ehrhardt J, Bredow M, Piccenini S, Zygmunt M.

Mol Hum Reprod. 2013 Aug;19(8):528-38. doi: 10.1093/molehr/gat023. Epub 2013 Mar 27.

PMID:
23538947
9.

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.

Brizuela L, Martin C, Jeannot P, Ader I, Gstalder C, Andrieu G, Bocquet M, Laffosse JM, Gomez-Brouchet A, Malavaud B, Sabbadini RA, Cuvillier O.

Mol Oncol. 2014 Oct;8(7):1181-95. doi: 10.1016/j.molonc.2014.04.001. Epub 2014 Apr 13.

10.

Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.

Yang L, Han Z, Tian L, Mai P, Zhang Y, Wang L, Li L.

Sci Rep. 2015 Sep 1;5:13423. doi: 10.1038/srep13423.

11.

TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts.

Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ.

Endocrinology. 2013 Oct;154(10):3745-52. doi: 10.1210/en.2013-1272. Epub 2013 Jul 16.

12.

Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model.

Tanaka K, Hashizume M, Mihara M, Yoshida H, Suzuki M, Matsumoto Y.

Clin Exp Immunol. 2014 Feb;175(2):172-80. doi: 10.1111/cei.12201.

13.

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.

Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Lüth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R.

J Clin Invest. 2013 Feb;123(2):666-81. doi: 10.1172/JCI64840. Epub 2013 Jan 16.

14.

Sphingosine-1-phosphate acts as a developmental stage specific inhibitor of platelet-derived growth factor-induced chemotaxis of osteoblasts.

Roelofsen T, Akkers R, Beumer W, Apotheker M, Steeghs I, van de Ven J, Gelderblom C, Garritsen A, Dechering K.

J Cell Biochem. 2008 Nov 1;105(4):1128-38. doi: 10.1002/jcb.21915.

PMID:
18819098
15.

Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.

Medlin MD, Staus DP, Dubash AD, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1779-86. doi: 10.1161/ATVBAHA.110.209395. Epub 2010 Aug 11.

16.

Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.

Sato C, Iwasaki T, Kitano S, Tsunemi S, Sano H.

Biochem Biophys Res Commun. 2012 Jun 22;423(1):200-5. doi: 10.1016/j.bbrc.2012.05.130. Epub 2012 May 31.

PMID:
22659743
17.

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3.

Okamoto H, Takuwa N, Yokomizo T, Sugimoto N, Sakurada S, Shigematsu H, Takuwa Y.

Mol Cell Biol. 2000 Dec;20(24):9247-61.

18.

Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1.

Becker S, von Otte S, Robenek H, Diedrich K, Nofer JR.

Biol Reprod. 2011 Mar;84(3):604-12. doi: 10.1095/biolreprod.110.084152. Epub 2010 Oct 27.

PMID:
20980685
20.

Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition.

Liu W, Liu B, Liu S, Zhang J, Lin S.

Eur J Pharmacol. 2016 Apr 5;776:19-25. doi: 10.1016/j.ejphar.2016.02.056. Epub 2016 Feb 26.

PMID:
26921757

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