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Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Yang M, Hardy AP, Chowdhury R, Loik ND, Scotti JS, McCullagh JS, Claridge TD, McDonough MA, Ge W, Schofield CJ.

Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1700-4. doi: 10.1002/anie.201208046. Epub 2013 Jan 7. No abstract available.


Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ.

J Biol Chem. 2008 Feb 15;283(7):3808-15. Epub 2007 Dec 5.


Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates.

Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A.

Epigenetics. 2014 Dec;9(12):1596-603. doi: 10.4161/15592294.2014.983381.


Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ.

J Biol Chem. 2011 Mar 4;286(9):7648-60. doi: 10.1074/jbc.M110.193540. Epub 2010 Dec 22.


Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ.

Biochem J. 2004 Nov 1;383(Pt. 3):429-37.


ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C.

Mol Cell Biol. 2007 Sep;27(18):6407-19. Epub 2007 Jul 16.


Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.

Flashman E, Hoffart LM, Hamed RB, Bollinger JM Jr, Krebs C, Schofield CJ.

FEBS J. 2010 Oct;277(19):4089-99. doi: 10.1111/j.1742-4658.2010.07804.x. Epub 2010 Aug 31.


Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

Wilkins SE, Hyvärinen J, Chicher J, Gorman JJ, Peet DJ, Bilton RL, Koivunen P.

Int J Biochem Cell Biol. 2009 Jul;41(7):1563-71. doi: 10.1016/j.biocel.2009.01.005. Epub 2009 Jan 20.


Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26.


Protein folding coupled to DNA binding in the catalytic domain of bacteriophage lambda integrase detected by mass spectrometry.

Kamadurai HB, Subramaniam S, Jones RB, Green-Church KB, Foster MP.

Protein Sci. 2003 Mar;12(3):620-6.


Characterization of a newly identified mycobacterial tautomerase with promiscuous dehalogenase and hydratase activities reveals a functional link to a recently diverged cis-3-chloroacrylic acid dehalogenase.

Baas BJ, Zandvoort E, Wasiel AA, Quax WJ, Poelarends GJ.

Biochemistry. 2011 Apr 12;50(14):2889-99. doi: 10.1021/bi200071k. Epub 2011 Mar 22.


Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation.

Singleton RS, Trudgian DC, Fischer R, Kessler BM, Ratcliffe PJ, Cockman ME.

J Biol Chem. 2011 Sep 30;286(39):33784-94. doi: 10.1074/jbc.M111.262808. Epub 2011 Jul 30.


Regulation of HIF: asparaginyl hydroxylation.

Peet D, Linke S.

Novartis Found Symp. 2006;272:37-49; discussion 49-53, 131-40. Review.


Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ.

J Biol Chem. 2002 Jul 19;277(29):26351-5. Epub 2002 May 31.


Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.

Science. 2001 Apr 20;292(5516):468-72. Epub 2001 Apr 5.


Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases.

Bruegge K, Jelkmann W, Metzen E.

Curr Med Chem. 2007;14(17):1853-62. Review.


Characterizing the specificity of activated Factor XIII for glutamine-containing substrate peptides.

Cleary DB, Maurer MC.

Biochim Biophys Acta. 2006 Jul;1764(7):1207-17. Epub 2006 May 23.


The use of dioxygen by HIF prolyl hydroxylase (PHD1).

McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ.

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1547-50.


Sortase A substrate specificity in GBS pilus 2a cell wall anchoring.

Necchi F, Nardi-Dei V, Biagini M, Assfalg M, Nuccitelli A, Cozzi R, Norais N, Telford JL, Rinaudo CD, Grandi G, Maione D.

PLoS One. 2011;6(10):e25300. doi: 10.1371/journal.pone.0025300. Epub 2011 Oct 4.

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