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Items: 1 to 20 of 309


Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes.

Li Z, Xu J, Xu P, Liu S, Yang Z.

Cell Prolif. 2013 Feb;46(1):76-85. doi: 10.1111/cpr.12010.


Inhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1.

Huang H, You Y, Lin X, Tang C, Gu X, Huang M, Qin Y, Tan J, Huang F.

Cell Physiol Biochem. 2017;41(1):163-172. doi: 10.1159/000455985. Epub 2017 Jan 18.


High glucose-induced apoptosis in cultured podocytes involves TRPC6-dependent calcium entry via the RhoA/ROCK pathway.

Yang H, Zhao B, Liao C, Zhang R, Meng K, Xu J, Jiao J.

Biochem Biophys Res Commun. 2013 May 3;434(2):394-400. doi: 10.1016/j.bbrc.2013.03.087. Epub 2013 Apr 6.


Glucose specifically regulates TRPC6 expression in the podocyte in an AngII-dependent manner.

Sonneveld R, van der Vlag J, Baltissen MP, Verkaart SA, Wetzels JF, Berden JH, Hoenderop JG, Nijenhuis T.

Am J Pathol. 2014 Jun;184(6):1715-26. doi: 10.1016/j.ajpath.2014.02.008. Epub 2014 Apr 13.


Calmodulin-dependent protein kinase II/cAMP response element-binding protein/Wnt/β-catenin signaling cascade regulates angiotensin II-induced podocyte injury and albuminuria.

Jiang L, Xu L, Song Y, Li J, Mao J, Zhao AZ, He W, Yang J, Dai C.

J Biol Chem. 2013 Aug 9;288(32):23368-79. doi: 10.1074/jbc.M113.460394. Epub 2013 Jun 26.


Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival.

Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K.

J Biol Chem. 2011 Jul 22;286(29):26003-15. doi: 10.1074/jbc.M111.223164. Epub 2011 May 25.


Wnt/β-Catenin Signaling Mediated-UCH-L1 Expression in Podocytes of Diabetic Nephropathy.

Zhang H, Luo W, Sun Y, Qiao Y, Zhang L, Zhao Z, Lv S.

Int J Mol Sci. 2016 Aug 25;17(9). pii: E1404. doi: 10.3390/ijms17091404.


BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury.

Mitu GM, Wang S, Hirschberg R.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1641-8. Epub 2007 Sep 5.


TGF-β1 induces podocyte injury through Smad3-ERK-NF-κB pathway and Fyn-dependent TRPC6 phosphorylation.

Yu L, Lin Q, Liao H, Feng J, Dong X, Ye J.

Cell Physiol Biochem. 2010;26(6):869-78. doi: 10.1159/000323996. Epub 2011 Jan 4.


Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria.

Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y.

J Am Soc Nephrol. 2009 Sep;20(9):1997-2008. doi: 10.1681/ASN.2009010019. Epub 2009 Jul 23.


Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease.

Li SY, Huang PH, Tarng DC, Lin TP, Yang WC, Chang YH, Yang AH, Lin CC, Yang MH, Chen JW, Schmid-Schönbein GW, Chien S, Chu PH, Lin SJ.

J Am Soc Nephrol. 2015 Dec;26(12):3072-84. doi: 10.1681/ASN.2014100989. Epub 2015 Apr 8.


Calcium entry via TRPC6 mediates albumin overload-induced endoplasmic reticulum stress and apoptosis in podocytes.

Chen S, He FF, Wang H, Fang Z, Shao N, Tian XJ, Liu JS, Zhu ZH, Wang YM, Wang S, Huang K, Zhang C.

Cell Calcium. 2011 Dec;50(6):523-9. doi: 10.1016/j.ceca.2011.08.008. Epub 2011 Sep 29.


ATP acting through P2Y receptors causes activation of podocyte TRPC6 channels: role of podocin and reactive oxygen species.

Roshanravan H, Dryer SE.

Am J Physiol Renal Physiol. 2014 May 1;306(9):F1088-97. doi: 10.1152/ajprenal.00661.2013. Epub 2014 Feb 19.


NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression.

Li R, Zhang L, Shi W, Zhang B, Liang X, Liu S, Wang W.

Exp Cell Res. 2013 Apr 15;319(7):992-1000. doi: 10.1016/j.yexcr.2013.01.007. Epub 2013 Jan 20.


FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression.

Ma R, Liu L, Jiang W, Yu Y, Song H.

Int J Clin Exp Pathol. 2015 Nov 1;8(11):14063-74. eCollection 2015.


NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury.

Wang Z, Wei X, Zhang Y, Ma X, Li B, Zhang S, Du P, Zhang X, Yi F.

Cell Physiol Biochem. 2009;24(5-6):619-26. doi: 10.1159/000257517. Epub 2009 Nov 4.


TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.

Zhang H, Ding J, Fan Q, Liu S.

Exp Biol Med (Maywood). 2009 Sep;234(9):1029-36. doi: 10.3181/0901-RM-11. Epub 2009 Jun 22.


TRPC6 channel as an emerging determinant of the podocyte injury susceptibility in kidney diseases.

Ilatovskaya DV, Staruschenko A.

Am J Physiol Renal Physiol. 2015 Sep 1;309(5):F393-7. doi: 10.1152/ajprenal.00186.2015. Epub 2015 Jun 17. Review.


Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6.

Yao XM, Liu YJ, Wang YM, Wang H, Zhu BB, Liang YP, Yao WG, Yu H, Wang NS, Zhang XM, Peng W.

Mol Med Rep. 2016 Jun;13(6):5149-56. doi: 10.3892/mmr.2016.5167. Epub 2016 Apr 22.


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