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Items: 1 to 20 of 77

1.

Bivalent ligands targeting multiple pathological factors involved in Alzheimer's disease.

Liu K, Gandhi R, Chen J, Zhang S.

ACS Med Chem Lett. 2012 Nov 8;3(11):942-946. Epub 2012 Sep 11.

2.

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.

Chojnacki JE, Liu K, Saathoff JM, Zhang S.

Bioorg Med Chem. 2015 Nov 15;23(22):7324-31. doi: 10.1016/j.bmc.2015.10.032. Epub 2015 Oct 24.

3.

"Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization.

Lenhart JA, Ling X, Gandhi R, Guo TL, Gerk PM, Brunzell DH, Zhang S.

J Med Chem. 2010 Aug 26;53(16):6198-209. doi: 10.1021/jm100601q.

PMID:
20666513
4.

Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer's Disease.

Saathoff JM, Liu K, Chojnacki JE, He L, Chen Q, Lesnefsky EJ, Zhang S.

Molecules. 2016 Mar 25;21(4):412. doi: 10.3390/molecules21040412.

5.

Bivalent Compound 17MN Exerts Neuroprotection through Interaction at Multiple Sites in a Cellular Model of Alzheimer's Disease.

Liu K, Chojnacki JE, Wade EE, Saathoff JM, Lesnefsky EJ, Chen Q, Zhang S.

J Alzheimers Dis. 2015;47(4):1021-33. doi: 10.3233/JAD-150242.

6.

Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin.

Chojnacki JE, Liu K, Yan X, Toldo S, Selden T, Estrada M, Rodríguez-Franco MI, Halquist MS, Ye D, Zhang S.

ACS Chem Neurosci. 2014 Aug 20;5(8):690-9. doi: 10.1021/cn500081s. Epub 2014 May 22.

7.

Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.

Manral A, Saini V, Meena P, Tiwari M.

Bioorg Med Chem. 2015 Oct 1;23(19):6389-403. doi: 10.1016/j.bmc.2015.08.024. Epub 2015 Aug 22.

PMID:
26337018
8.

Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.

Luo W, Li YP, Tan JH, Gu LQ, Huang ZS.

J Enzyme Inhib Med Chem. 2011 Oct;26(5):706-11. doi: 10.3109/14756366.2010.548329. Epub 2011 Jan 21.

PMID:
21250822
9.

Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease.

Liu K, Guo TL, Chojnacki J, Lee HG, Wang X, Siedlak SL, Rao W, Zhu X, Zhang S.

ACS Chem Neurosci. 2012 Feb 15;3(2):141-146. Epub 2011 Dec 11.

10.

Design, synthesis and evaluation of multifunctional salphen derivatives for the treatment of Alzheimer's disease.

Jiang N, Li SY, Xie SS, Li ZR, Wang KD, Wang XB, Kong LY.

Eur J Med Chem. 2014 Nov 24;87:540-51. doi: 10.1016/j.ejmech.2014.10.004. Epub 2014 Oct 2.

PMID:
25290683
12.

Multivalent & multifunctional ligands to beta-amyloid.

Kim Y, Lee JH, Ryu J, Kim DJ.

Curr Pharm Des. 2009;15(6):637-58. Review.

PMID:
19199987
13.

Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

Storr T, Merkel M, Song-Zhao GX, Scott LE, Green DE, Bowen ML, Thompson KH, Patrick BO, Schugar HJ, Orvig C.

J Am Chem Soc. 2007 Jun 13;129(23):7453-63. Epub 2007 May 19.

PMID:
17511455
14.

Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.

Nimczick M, Pemp D, Darras FH, Chen X, Heilmann J, Decker M.

Bioorg Med Chem. 2014 Aug 1;22(15):3938-46. doi: 10.1016/j.bmc.2014.06.008. Epub 2014 Jun 13.

PMID:
24984935
16.

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway.

Thapa A, Jett SD, Chi EY.

ACS Chem Neurosci. 2016 Jan 20;7(1):56-68. doi: 10.1021/acschemneuro.5b00214. Epub 2015 Nov 17.

PMID:
26529184
17.

Syntheses And Evaluation Of Asymmetric Curcumin Analogues As Potential Multifunctional Agents For The Treatment Of Alzheimer's Disease.

Zhai P, Xia CL, Tan JH, Li D, Ou TM, Huang SL, Gu LQ, Huang ZS.

Curr Alzheimer Res. 2015;12(5):403-14.

PMID:
25938868
18.

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.

Hebda M, Bajda M, Więckowska A, Szałaj N, Pasieka A, Panek D, Godyń J, Wichur T, Knez D, Gobec S, Malawska B.

Molecules. 2016 Mar 26;21(4):410. doi: 10.3390/molecules21040410.

19.

Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease.

Calabrese V, Butterfield DA, Stella AM.

Ital J Biochem. 2003 Dec;52(4):177-81. Review.

PMID:
15141484
20.

Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.

Portoghese PS, Larson DL, Sayre LM, Yim CB, Ronsisvalle G, Tam SW, Takemori AE.

J Med Chem. 1986 Oct;29(10):1855-61.

PMID:
3020244

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