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Items: 1 to 20 of 263

1.

Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo.

Al-Zoubi M, Salem AF, Martinez-Outschoorn UE, Whitaker-Menezes D, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Arafat H, Bevilacqua G, Sotgia F, Lisanti MP.

Cell Cycle. 2013 Feb 1;12(3):480-90. doi: 10.4161/cc.23370. Epub 2012 Feb 1.

2.

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.

Cell Cycle. 2010 Sep 1;9(17):3515-33. Epub 2010 Sep 9.

3.

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth.

Capparelli C, Whitaker-Menezes D, Guido C, Balliet R, Pestell TG, Howell A, Sneddon S, Pestell RG, Martinez-Outschoorn U, Lisanti MP, Sotgia F.

Cell Cycle. 2012 Jun 15;11(12):2272-84. doi: 10.4161/cc.20717. Epub 2012 Jun 15.

4.

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S, Martinez-Outschoorn U, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Aug 15;11(16):3019-35. doi: 10.4161/cc.21384. Epub 2012 Aug 9.

5.

Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.

Avena P, Anselmo W, Whitaker-Menezes D, Wang C, Pestell RG, Lamb RS, Hulit J, Casaburi I, Andò S, Martinez-Outschoorn UE, Lisanti MP, Sotgia F.

Cell Cycle. 2013 May 1;12(9):1360-70. doi: 10.4161/cc.24289. Epub 2013 Apr 10.

6.

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts.

Trimmer C, Sotgia F, Whitaker-Menezes D, Balliet RM, Eaton G, Martinez-Outschoorn UE, Pavlides S, Howell A, Iozzo RV, Pestell RG, Scherer PE, Capozza F, Lisanti MP.

Cancer Biol Ther. 2011 Feb 15;11(4):383-94. Epub 2011 Feb 15.

7.

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.

Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, Birbe R, Tsirigos A, Martinez-Outschoorn U, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Jun 15;11(12):2285-302. doi: 10.4161/cc.20718. Epub 2012 Jun 15.

8.

Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.

Salem AF, Al-Zoubi MS, Whitaker-Menezes D, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Galbiati F, Bevilacqua G, Sotgia F, Lisanti MP.

Cell Cycle. 2013 Mar 1;12(5):818-25. doi: 10.4161/cc.23722. Epub 2013 Feb 6.

9.

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.

Chiavarina B, Whitaker-Menezes D, Migneco G, Martinez-Outschoorn UE, Pavlides S, Howell A, Tanowitz HB, Casimiro MC, Wang C, Pestell RG, Grieshaber P, Caro J, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Sep 1;9(17):3534-51. Epub 2010 Sep 4.

10.

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.

Balliet RM, Capparelli C, Guido C, Pestell TG, Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Chiavarina B, Pestell RG, Howell A, Sotgia F, Lisanti MP.

Cell Cycle. 2011 Dec 1;10(23):4065-73. doi: 10.4161/cc.10.23.18254. Epub 2011 Dec 1.

11.

Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.

Salem AF, Howell A, Sartini M, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Nov 15;11(22):4167-73. doi: 10.4161/cc.22316. Epub 2012 Oct 9.

12.

Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.

Sanchez-Alvarez R, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Rubin E, Lisanti MP, Sotgia F.

Cell Cycle. 2013 Jan 1;12(1):172-82. doi: 10.4161/cc.23058. Epub 2012 Dec 20.

13.

Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.

Castello-Cros R, Bonuccelli G, Molchansky A, Capozza F, Witkiewicz AK, Birbe RC, Howell A, Pestell RG, Whitaker-Menezes D, Sotgia F, Lisanti MP.

Cell Cycle. 2011 Jun 15;10(12):2021-34. Epub 2011 Jun 15.

14.

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP.

Cancer Biol Ther. 2011 Dec 15;12(12):1101-13. doi: 10.4161/cbt.12.12.18703. Epub 2011 Dec 15.

15.

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.

Migneco G, Whitaker-Menezes D, Chiavarina B, Castello-Cros R, Pavlides S, Pestell RG, Fatatis A, Flomenberg N, Tsirigos A, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2010 Jun 15;9(12):2412-22. Epub 2010 Jun 15.

PMID:
20562527
16.

Adenovirus-mediated ING4/IL-24 double tumor suppressor gene co-transfer enhances antitumor activity in human breast cancer cells.

Zhao Y, Li Z, Sheng W, Miao J, Yang J.

Oncol Rep. 2012 Oct;28(4):1315-24. doi: 10.3892/or.2012.1930. Epub 2012 Jul 24.

PMID:
22842937
17.

Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and xenografted tumors.

Amemiya Y, Yang W, Benatar T, Nofech-Mozes S, Yee A, Kahn H, Holloway C, Seth A.

Breast Cancer Res Treat. 2011 Apr;126(2):373-84. doi: 10.1007/s10549-010-0921-0. Epub 2010 May 13.

PMID:
20464481
18.

Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo.

Li Z, Xie Y, Sheng W, Miao J, Xiang J, Yang J.

Cancer Biother Radiopharm. 2010 Aug;25(4):427-37. doi: 10.1089/cbr.2010.0778.

PMID:
20707719
19.

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.

Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Oct 1;11(19):3599-610. doi: 10.4161/cc.21884. Epub 2012 Aug 30.

20.

Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis.

Morrison BL, Mullendore ME, Stockwin LH, Borgel S, Hollingshead MG, Newton DL.

Cancer Med. 2013 Oct;2(5):687-700. doi: 10.1002/cam4.107. Epub 2013 Jul 23.

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