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Diarylquinoline compounds induce autophagy-associated cell death by inhibiting the Akt pathway and increasing reactive oxygen species in human nasopharyngeal carcinoma cells.

Cai Y, Wan Z, Sun T, Shi Y, Sun Y, Huang P, Li S, Jiang W.

Oncol Rep. 2013 Mar;29(3):983-92. doi: 10.3892/or.2012.2207. Epub 2012 Dec 24.


Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells.

Wang KF, Yang H, Jiang WQ, Li S, Cai YC.

Int J Mol Med. 2015 Dec;36(6):1556-62. doi: 10.3892/ijmm.2015.2378. Epub 2015 Oct 16.


Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition.

Schmukler E, Shai B, Ehrlich M, Pinkas-Kramarski R.

PLoS One. 2012;7(5):e36828. doi: 10.1371/journal.pone.0036828. Epub 2012 May 14.


Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells.

Yang J, Zhou Y, Cheng X, Fan Y, He S, Li S, Ye H, Xie C, Wu W, Li C, Pei H, Li L, Wei Z, Peng A, Wei Y, Li W, Chen L.

Sci Rep. 2015 Jan 9;5:7697. doi: 10.1038/srep07697.


Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells.

Zhang H, Kong X, Kang J, Su J, Li Y, Zhong J, Sun L.

Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.


1-Methyl-4-phenylpyridinium-induced cell death via autophagy through a Bcl-2/Beclin 1 complex-dependent pathway.

Nopparat C, Porter JE, Ebadi M, Govitrapong P.

Neurochem Res. 2014 Feb;39(2):225-32. doi: 10.1007/s11064-013-1208-8. Epub 2013 Dec 11.


Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation.

Pang XL, He G, Liu YB, Wang Y, Zhang B.

World J Gastroenterol. 2013 Mar 21;19(11):1736-48. doi: 10.3748/wjg.v19.i11.1736.


[A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells].

Zhou WJ, Deng R, Feng GK, Zhu XF.

Ai Zheng. 2009 Oct;28(10):1049-53. Chinese.


Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells.

Hu H, Chai Y, Wang L, Zhang J, Lee HJ, Kim SH, Lü J.

Mol Cancer Ther. 2009 Oct;8(10):2833-43. doi: 10.1158/1535-7163.MCT-09-0288.


1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S.

BMC Cancer. 2010 Dec 3;10:669. doi: 10.1186/1471-2407-10-669.


Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway.

Zhang DM, Liu JS, Deng LJ, Chen MF, Yiu A, Cao HH, Tian HY, Fung KP, Kurihara H, Pan JX, Ye WC.

Carcinogenesis. 2013 Jun;34(6):1331-42. doi: 10.1093/carcin/bgt060. Epub 2013 Feb 7.


The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.

Ji D, Zhang Z, Cheng L, Chang J, Wang S, Zheng B, Zheng R, Sun Z, Wang C, Zhang Z, Liu R, Zhang X, Liu X, Wang X, Li J.

PLoS One. 2014 Jan 9;9(1):e85116. doi: 10.1371/journal.pone.0085116. eCollection 2014.


Role of autophagy in apoptosis induction by methylene chloride extracts of Mori cortex in NCI-H460 human lung carcinoma cells.

Park SH, Chi GY, Eom HS, Kim GY, Hyun JW, Kim WJ, Lee SJ, Yoo YH, Choi YH.

Int J Oncol. 2012 Jun;40(6):1929-40. doi: 10.3892/ijo.2012.1386. Epub 2012 Feb 22.


Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells.

Singh BN, Kumar D, Shankar S, Srivastava RK.

Biochem Pharmacol. 2012 Nov 1;84(9):1154-63. doi: 10.1016/j.bcp.2012.08.007. Epub 2012 Aug 15.


Autophagy contributes to ING4-induced glioma cell death.

Gong A, Ye S, Xiong E, Guo W, Zhang Y, Peng W, Shao G, Jin J, Zhang Z, Yang J, Gao J.

Exp Cell Res. 2013 Jul 15;319(12):1714-23. doi: 10.1016/j.yexcr.2013.05.004. Epub 2013 May 14.


The effects of pyrrolo[1,2-b][1,2,5]benzothiadiazepines in MEC1 cells.

Maffei G, Mirone G, Perna S, Di Stefano C.

J Cell Biochem. 2015 Feb;116(2):339-49. doi: 10.1002/jcb.24977.


Effects of small interfering RNA inhibit Class I phosphoinositide 3-kinase on human gastric cancer cells.

Zhu BS, Yu LY, Zhao K, Wu YY, Cheng XL, Wu Y, Zhong FY, Gong W, Chen Q, Xing CG.

World J Gastroenterol. 2013 Mar 21;19(11):1760-9. doi: 10.3748/wjg.v19.i11.1760.


Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways.

Mujumdar N, Mackenzie TN, Dudeja V, Chugh R, Antonoff MB, Borja-Cacho D, Sangwan V, Dawra R, Vickers SM, Saluja AK.

Gastroenterology. 2010 Aug;139(2):598-608. doi: 10.1053/j.gastro.2010.04.046. Epub 2010 Apr 29.


1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione Induces G1 Cell Cycle Arrest and Autophagy in HeLa Cervical Cancer Cells.

Tsai JH, Hsu LS, Huang HC, Lin CL, Pan MH, Hong HM, Chen WJ.

Int J Mol Sci. 2016 Aug 5;17(8). pii: E1274. doi: 10.3390/ijms17081274.

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