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Items: 1 to 20 of 113

1.

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.

Kirino Y, Bertsias G, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sacli FS, Erer B, Inoko H, Emrence Z, Cakar A, Abaci N, Ustek D, Satorius C, Ueda A, Takeno M, Kim Y, Wood GM, Ombrello MJ, Meguro A, Gül A, Remmers EF, Kastner DL.

Nat Genet. 2013 Feb;45(2):202-7. doi: 10.1038/ng.2520. Epub 2013 Jan 6.

2.

Brief report: association of CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 With Behçet's disease in Iranians.

Sousa I, Shahram F, Francisco D, Davatchi F, Abdollahi BS, Ghaderibarmi F, Nadji A, Mojarad Shafiee N, Xavier JM, Oliveira SA.

Arthritis Rheumatol. 2015 Oct;67(10):2742-8. doi: 10.1002/art.39240.

3.

Genetics of Behçet's disease: lessons learned from genomewide association studies.

Gül A.

Curr Opin Rheumatol. 2014 Jan;26(1):56-63. doi: 10.1097/BOR.0000000000000003. Review.

PMID:
24257369
4.

A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers.

Takeuchi M, Ombrello MJ, Kirino Y, Erer B, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Watts NR, Gül A, Kastner DL, Remmers EF.

Ann Rheum Dis. 2016 Dec;75(12):2208-2211. doi: 10.1136/annrheumdis-2015-209059. Epub 2016 May 23.

5.

The immunogenetics of Behçet's disease: A comprehensive review.

Takeuchi M, Kastner DL, Remmers EF.

J Autoimmun. 2015 Nov;64:137-48. doi: 10.1016/j.jaut.2015.08.013. Epub 2015 Sep 5. Review.

6.

Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population.

Conde-Jaldón M, Montes-Cano MA, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, González-León R, Espinosa G, Graña-Gil G, Sánchez-Bursón J, González-Gay MA, Barnosi-Marín AC, Solans R, Fanlo P, Carballeira MR, Camps T, Castañeda S, Martín J, González-Escribano MF.

PLoS One. 2014 Jul 14;9(7):e102100. doi: 10.1371/journal.pone.0102100. eCollection 2014.

7.

The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing.

Guasp P, Barnea E, González-Escribano MF, Jiménez-Reinoso A, Regueiro JR, Admon A, López de Castro JA.

J Biol Chem. 2017 Jun 9;292(23):9680-9689. doi: 10.1074/jbc.M117.789180. Epub 2017 Apr 26.

PMID:
28446606
8.

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease.

Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, Gül A.

Nat Genet. 2010 Aug;42(8):698-702. doi: 10.1038/ng.625. Epub 2010 Jul 11.

9.

Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet's disease susceptibility.

Hou S, Xiao X, Li F, Jiang Z, Kijlstra A, Yang P.

Hum Genet. 2012 Dec;131(12):1841-50. doi: 10.1007/s00439-012-1200-4. Epub 2012 Jul 25.

PMID:
22829007
10.

Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease.

Hughes T, Coit P, Adler A, Yilmaz V, Aksu K, Düzgün N, Keser G, Cefle A, Yazici A, Ergen A, Alpsoy E, Salvarani C, Casali B, Kötter I, Gutierrez-Achury J, Wijmenga C, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH.

Nat Genet. 2013 Mar;45(3):319-24. doi: 10.1038/ng.2551. Epub 2013 Feb 10.

PMID:
23396137
11.

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P, Trembath RC.

Nat Genet. 2010 Nov;42(11):985-90. doi: 10.1038/ng.694. Epub 2010 Oct 17.

12.

HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population.

Montes-Cano MA, Conde-Jaldón M, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, Castillo-Palma MJ, Espinosa G, Graña-Gil G, González-Gay MA, Barnosi-Marín AC, Solans R, Fanlo P, Camps T, Castañeda S, Sánchez-Bursón J, Núñez-Roldán A, Martín J, González-Escribano MF.

Arthritis Res Ther. 2013 Oct 4;15(5):R145. doi: 10.1186/ar4328.

13.

Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.

Hou S, Yang Z, Du L, Jiang Z, Shu Q, Chen Y, Li F, Zhou Q, Ohno S, Chen R, Kijlstra A, Rosenbaum JT, Yang P.

Arthritis Rheum. 2012 Dec;64(12):4104-13. doi: 10.1002/art.37708.

14.

Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals.

Bettencourt BF, Rocha FL, Alves H, Amorim R, Caetano-Lopes J, Vieira-Sousa E, Pimentel-Santos F, Lima M, Porto G, Branco JC, Fonseca JE, Bruges-Armas J.

Rheumatology (Oxford). 2013 Dec;52(12):2168-76. doi: 10.1093/rheumatology/ket269. Epub 2013 Sep 17.

PMID:
24046467
15.

Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility.

Takeuchi M, Mizuki N, Meguro A, Ombrello MJ, Kirino Y, Satorius C, Le J, Blake M, Erer B, Kawagoe T, Ustek D, Tugal-Tutkun I, Seyahi E, Ozyazgan Y, Sousa I, Davatchi F, Francisco V, Shahram F, Abdollahi BS, Nadji A, Shafiee NM, Ghaderibarmi F, Ohno S, Ueda A, Ishigatsubo Y, Gadina M, Oliveira SA, Gül A, Kastner DL, Remmers EF.

Nat Genet. 2017 Mar;49(3):438-443. doi: 10.1038/ng.3786. Epub 2017 Feb 6.

16.

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.

López de Castro JA, Alvarez-Navarro C, Brito A, Guasp P, Martín-Esteban A, Sanz-Bravo A.

Mol Immunol. 2016 Sep;77:193-204. doi: 10.1016/j.molimm.2016.08.005. Epub 2016 Aug 11. Review.

PMID:
27522479
17.

Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.

Kim ES, Kim SW, Moon CM, Park JJ, Kim TI, Kim WH, Cheon JH.

Life Sci. 2012 May 22;90(19-20):740-6. doi: 10.1016/j.lfs.2012.03.017. Epub 2012 Mar 27.

PMID:
22483685
18.

Behçet's disease risk association fine-mapped on the IL23R-IL12RB2 intergenic region in Koreans.

Kang EH, Kim S, Park MY, Choi JY, Choi IA, Kim MJ, Ha YJ, Lee EY, Lee YJ, Lee EB, Kang C, Song YW.

Arthritis Res Ther. 2017 Oct 10;19(1):227. doi: 10.1186/s13075-017-1435-5.

19.

Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population.

Davidson SI, Wu X, Liu Y, Wei M, Danoy PA, Thomas G, Cai Q, Sun L, Duncan E, Wang N, Yu Q, Xu A, Fu Y, Brown MA, Xu H.

Arthritis Rheum. 2009 Nov;60(11):3263-8. doi: 10.1002/art.24933.

20.

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.

Cortes A, Pulit SL, Leo PJ, Pointon JJ, Robinson PC, Weisman MH, Ward M, Gensler LS, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre Ø, Tuomilehto J, Laiho K, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Haroon N, Mulero J, Blanco FJ, Gonzalez-Gay MA, Lopez-Larrea C, Bowness P, Gaffney K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Crusius JB, van der Horst-Bruinsma IE, Valle-Oñate R, Romero-Sánchez C, Hansen IM, Pimentel-Santos FM, Inman RD, Martin J, Breban M, Wordsworth BP, Reveille JD, Evans DM, de Bakker PI, Brown MA.

Nat Commun. 2015 May 21;6:7146. doi: 10.1038/ncomms8146.

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