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Items: 1 to 20 of 160

1.

Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling.

Chandrasekera PC, Wan TC, Gizewski ET, Auchampach JA, Lasley RD.

Cell Signal. 2013 Apr;25(4):736-42. doi: 10.1016/j.cellsig.2012.12.022. Epub 2013 Jan 3.

2.

Beta 1/beta 2-adrenergic receptor heterodimerization regulates beta 2-adrenergic receptor internalization and ERK signaling efficacy.

Lavoie C, Mercier JF, Salahpour A, Umapathy D, Breit A, Villeneuve LR, Zhu WZ, Xiao RP, Lakatta EG, Bouvier M, Hébert TE.

J Biol Chem. 2002 Sep 20;277(38):35402-10. Epub 2002 Jul 24.

3.

Hetero-oligomerization between adenosine A₁ and thromboxane A₂ receptors and cellular signal transduction on stimulation with high and low concentrations of agonists for both receptors.

Mizuno N, Suzuki T, Hirasawa N, Nakahata N.

Eur J Pharmacol. 2012 Feb 29;677(1-3):5-14. doi: 10.1016/j.ejphar.2011.12.006. Epub 2011 Dec 16.

PMID:
22200626
4.

Structure-Based Prediction of G-Protein-Coupled Receptor Ligand Function: A β-Adrenoceptor Case Study.

Kooistra AJ, Leurs R, de Esch IJ, de Graaf C.

J Chem Inf Model. 2015 May 26;55(5):1045-61. doi: 10.1021/acs.jcim.5b00066. Epub 2015 May 1.

PMID:
25848966
5.

Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.

Nguyen AT, Baltos JA, Thomas T, Nguyen TD, Muñoz LL, Gregory KJ, White PJ, Sexton PM, Christopoulos A, May LT.

Mol Pharmacol. 2016 Dec;90(6):703-714. Epub 2016 Sep 28.

PMID:
27683014
6.

β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.

Khan M, Mohsin S, Avitabile D, Siddiqi S, Nguyen J, Wallach K, Quijada P, McGregor M, Gude N, Alvarez R, Tilley DG, Koch WJ, Sussman MA.

Circ Res. 2013 Feb 1;112(3):476-86. doi: 10.1161/CIRCRESAHA.112.280735. Epub 2012 Dec 14.

7.

Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation.

Jordan BA, Trapaidze N, Gomes I, Nivarthi R, Devi LA.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):343-8.

8.

Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.

Komatsu S, Dobson JG Jr, Ikebe M, Shea LG, Fenton RA.

J Cell Physiol. 2012 Sep;227(9):3201-7. doi: 10.1002/jcp.24008.

9.
10.

Biochemical assay of G protein-coupled receptor oligomerization: adenosine A1 and thromboxane A2 receptors form the novel functional hetero-oligomer.

Mizuno N, Suzuki T, Kishimoto Y, Hirasawa N.

Methods Cell Biol. 2013;117:213-27. doi: 10.1016/B978-0-12-408143-7.00012-8.

PMID:
24143980
11.

Receptor specific crosstalk and modulation of signaling upon heterodimerization between β1-adrenergic receptor and somatostatin receptor-5.

Somvanshi RK, War SA, Chaudhari N, Qiu X, Kumar U.

Cell Signal. 2011 May;23(5):794-811. doi: 10.1016/j.cellsig.2011.01.002. Epub 2011 Jan 14.

PMID:
21238583
12.

The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer spontaneous activity of the receptor.

Chakir K, Xiang Y, Yang D, Zhang SJ, Cheng H, Kobilka BK, Xiao RP.

Mol Pharmacol. 2003 Nov;64(5):1048-58.

13.

Divergent agonist selectivity in activating β1- and β2-adrenoceptors for G-protein and arrestin coupling.

Casella I, Ambrosio C, Grò MC, Molinari P, Costa T.

Biochem J. 2011 Aug 15;438(1):191-202. doi: 10.1042/BJ20110374.

PMID:
21561432
14.

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and β2 adrenergic receptors.

Barlow N, Baker SP, Scammells PJ.

ChemMedChem. 2013 Dec;8(12):2036-46. doi: 10.1002/cmdc.201300286. Epub 2013 Sep 18.

PMID:
24106065
16.
17.

Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.

Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C.

J Pharmacol Exp Ther. 2016 Oct;359(1):73-81. doi: 10.1124/jpet.116.232884. Epub 2016 Jul 22.

18.

Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

Wrzal PK, Devost D, Pétrin D, Goupil E, Iorio-Morin C, Laporte SA, Zingg HH, Hébert TE.

Cell Signal. 2012 Jan;24(1):342-50. doi: 10.1016/j.cellsig.2011.09.020. Epub 2011 Sep 22.

PMID:
21963428
19.
20.

Functional interactions between the oxytocin receptor and the β2-adrenergic receptor: implications for ERK1/2 activation in human myometrial cells.

Wrzal PK, Goupil E, Laporte SA, Hébert TE, Zingg HH.

Cell Signal. 2012 Jan;24(1):333-41. doi: 10.1016/j.cellsig.2011.09.019. Epub 2011 Sep 22.

PMID:
21964067

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