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Chimaerin suppresses Rac1 activation at the apical membrane to maintain the cyst structure.

Yagi S, Matsuda M, Kiyokawa E.

PLoS One. 2012;7(12):e52258. doi: 10.1371/journal.pone.0052258. Epub 2012 Dec 20.


Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse.

Shi L, Fu WY, Hung KW, Porchetta C, Hall C, Fu AK, Ip NY.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16347-52. Epub 2007 Oct 2.


Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance.

Yagi S, Matsuda M, Kiyokawa E.

EMBO Rep. 2012 Mar 1;13(3):237-43. doi: 10.1038/embor.2011.249.


The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis.

Valdez CM, Murphy GG, Beg AA.

Mol Cell Neurosci. 2016 Sep;75:14-26. doi: 10.1016/j.mcn.2016.06.002. Epub 2016 Jun 11.


Formation of multicellular epithelial structures.

Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W.

Novartis Found Symp. 2005;269:193-200; discussion 200-5, 223-30.


Numb is a negative regulator of HGF dependent cell scattering and Rac1 activation.

Lau KM, McGlade CJ.

Exp Cell Res. 2011 Feb 15;317(4):539-51. doi: 10.1016/j.yexcr.2010.12.005. Epub 2010 Dec 11.


Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling.

Caloca MJ, Delgado P, Alarcón B, Bustelo XR.

Cell Signal. 2008 Apr;20(4):758-70. doi: 10.1016/j.cellsig.2007.12.015. Epub 2007 Dec 28.


The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells.

Criss AK, Ahlgren DM, Jou TS, McCormick BA, Casanova JE.

J Cell Sci. 2001 Apr;114(Pt 7):1331-41.


Rac GTPase-activating protein (Rac GAP) α1-Chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons.

Marland JR, Pan D, Buttery PC.

J Biol Chem. 2011 Jan 7;286(1):199-207. doi: 10.1074/jbc.M110.166728. Epub 2010 Nov 5.


Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor.

Yasuda S, Kai M, Imai S, Kanoh H, Sakane F.

FEBS Lett. 2007 Feb 6;581(3):551-7. Epub 2007 Jan 18.


Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin.

Colón-González F, Leskow FC, Kazanietz MG.

J Biol Chem. 2008 Dec 12;283(50):35247-57. doi: 10.1074/jbc.M806264200. Epub 2008 Sep 30.


Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.

Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I.

Neurosci Lett. 2015 Mar 30;591:19-24. doi: 10.1016/j.neulet.2015.02.013. Epub 2015 Feb 9.


Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells.

Dipaolo BC, Davidovich N, Kazanietz MG, Margulies SS.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L141-53. doi: 10.1152/ajplung.00298.2012. Epub 2013 May 17.


The diacylglycerol-binding protein alpha1-chimaerin regulates dendritic morphology.

Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P.

Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1924-9. Epub 2006 Jan 30.


Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells.

Siliceo M, García-Bernal D, Carrasco S, Díaz-Flores E, Coluccio Leskow F, Teixidó J, Kazanietz MG, Mérida I.

J Cell Sci. 2006 Jan 1;119(Pt 1):141-52. Epub 2005 Dec 13. Erratum in: J Cell Sci. 2006 Jan 15;119(Pt 2):388. Leskow, Federico C [corrected to Coluccio Leskow, Federico].

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