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8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction.

Sampath H, Vartanian V, Rollins MR, Sakumi K, Nakabeppu Y, Lloyd RS.

PLoS One. 2012;7(12):e51697. doi: 10.1371/journal.pone.0051697. Epub 2012 Dec 17.


8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.

Vartanian V, Tumova J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd RS, Sampath H.

PLoS One. 2017 Jul 20;12(7):e0181687. doi: 10.1371/journal.pone.0181687. eCollection 2017.


Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance.

Wang XA, Zhang R, Zhang S, Deng S, Jiang D, Zhong J, Yang L, Wang T, Hong S, Guo S, She ZG, Zhang XD, Li H.

Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E485-95. doi: 10.1152/ajpendo.00505.2012. Epub 2013 May 21.


Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M.

Gastroenterology. 2014 Feb;146(2):539-49.e7. doi: 10.1053/j.gastro.2013.10.059. Epub 2013 Nov 1.


Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK, R Stephen L.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E724-34. doi: 10.1152/ajpendo.00387.2010. Epub 2011 Feb 1.


Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration.

Gauger KJ, Bassa LM, Henchey EM, Wyman J, Bentley B, Brown M, Shimono A, Schneider SS.

PLoS One. 2013 Dec 5;8(12):e78320. doi: 10.1371/journal.pone.0078320. eCollection 2013.


Metabolic remodeling of white adipose tissue in obesity.

Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG.

Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E262-77. doi: 10.1152/ajpendo.00271.2013. Epub 2014 Jun 10.


Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice.

Do GM, Oh HY, Kwon EY, Cho YY, Shin SK, Park HJ, Jeon SM, Kim E, Hur CG, Park TS, Sung MK, McGregor RA, Choi MS.

Mol Nutr Food Res. 2011 Sep;55 Suppl 2:S173-85. doi: 10.1002/mnfr.201100064. Epub 2011 May 25.


Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet.

Gao M, Ma Y, Cui R, Liu D.

J Control Release. 2014 Jul 10;185:1-11. doi: 10.1016/j.jconrel.2014.03.047. Epub 2014 Apr 18.


Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.

Liu D, Croteau DL, Souza-Pinto N, Pitta M, Tian J, Wu C, Jiang H, Mustafa K, Keijzers G, Bohr VA, Mattson MP.

J Cereb Blood Flow Metab. 2011 Feb;31(2):680-92. doi: 10.1038/jcbfm.2010.147. Epub 2010 Aug 25.


Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis.

Chiu HK, Qian K, Ogimoto K, Morton GJ, Wisse BE, Agrawal N, McDonald TO, Schwartz MW, Dichek HL.

Endocrinology. 2010 Mar;151(3):993-1001. doi: 10.1210/en.2009-1100. Epub 2010 Jan 7.


Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC.

J Lipid Res. 2012 Jun;53(6):1080-92. doi: 10.1194/jlr.M023382. Epub 2012 Apr 9.


Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction.

Urs S, Henderson T, Le P, Rosen CJ, Liaw L.

Br J Nutr. 2012 Sep 28;108(6):1025-33. doi: 10.1017/S0007114511006209. Epub 2011 Dec 6.


The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice.

Yazdi M, Ahnmark A, William-Olsson L, Snaith M, Turner N, Osla F, Wedin M, Asztély AK, Elmgren A, Bohlooly-Y M, Schreyer S, Lindén D.

Biochem Biophys Res Commun. 2008 May 16;369(4):1065-70. doi: 10.1016/j.bbrc.2008.02.156. Epub 2008 Mar 11.


Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.

de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA.

Cancer Res. 2001 Jul 15;61(14):5378-81.


High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance.

Gupte AA, Minze LJ, Reyes M, Ren Y, Wang X, Brunner G, Ghosn M, Cordero-Reyes AM, Ding K, Pratico D, Morrisett J, Shi ZZ, Hamilton DJ, Lyon CJ, Hsueh WA.

Endocrinology. 2013 Aug;154(8):2650-62. doi: 10.1210/en.2012-2272. Epub 2013 May 24.


Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice.

McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E834-44. doi: 10.1152/ajpendo.00297.2013. Epub 2013 Aug 6.


Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.

Jeong JK, Szabo G, Raso GM, Meli R, Diano S.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1502-10. doi: 10.1152/ajpendo.00544.2011. Epub 2012 Mar 27.


Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.

Malloy VL, Perrone CE, Mattocks DA, Ables GP, Caliendo NS, Orentreich DS, Orentreich N.

Metabolism. 2013 Nov;62(11):1651-61. doi: 10.1016/j.metabol.2013.06.012. Epub 2013 Aug 5.


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