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TNF-α mediates increased susceptibility to ischemic AKI in diabetes.

Gao G, Zhang B, Ramesh G, Betterly D, Tadagavadi RK, Wang W, Reeves WB.

Am J Physiol Renal Physiol. 2013 Mar 1;304(5):F515-21. doi: 10.1152/ajprenal.00533.2012. Epub 2013 Jan 2.


Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy.

Park SW, Chen SW, Kim M, Brown KM, Kolls JK, D'Agati VD, Lee HT.

Lab Invest. 2011 Jan;91(1):63-84. doi: 10.1038/labinvest.2010.151. Epub 2010 Aug 9.


TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury.

White LE, Santora RJ, Cui Y, Moore FA, Hassoun HT.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep;303(5):L449-59. doi: 10.1152/ajplung.00301.2011. Epub 2012 Jun 22.


Renal PKC-ε deficiency attenuates acute kidney injury and ischemic allograft injury via TNF-α-dependent inhibition of apoptosis and inflammation.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F.

Am J Physiol Renal Physiol. 2014 Sep 15;307(6):F718-26. doi: 10.1152/ajprenal.00372.2013. Epub 2014 Jul 23.


Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes.

Ladefoged M, Buschard K, Hansen AM.

APMIS. 2013 Jun;121(6):531-8. doi: 10.1111/apm.12018. Epub 2012 Nov 8.


Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury.

Lee JW, Kim SC, Ko YS, Lee HY, Cho E, Kim MG, Jo SK, Cho WY, Kim HK.

Biochem Biophys Res Commun. 2014 Feb 7;444(2):121-7. doi: 10.1016/j.bbrc.2014.01.005. Epub 2014 Jan 14.


Ischemic proximal tubular injury primes mice to endotoxin-induced TNF-alpha generation and systemic release.

Zager RA, Johnson AC, Hanson SY, Lund S.

Am J Physiol Renal Physiol. 2005 Aug;289(2):F289-97. Epub 2005 Mar 29.


Delayed recovery of renal regional blood flow in diabetic mice subjected to acute ischemic kidney injury.

Shi H, Patschan D, Epstein T, Goligorsky MS, Winaver J.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1512-7. Epub 2007 Sep 19.


Acute hepatic ischemic-reperfusion injury induces a renal cortical "stress response," renal "cytoresistance," and an endotoxin hyperresponsive state.

Zager RA, Johnson AC, Frostad KB.

Am J Physiol Renal Physiol. 2014 Oct 1;307(7):F856-68. doi: 10.1152/ajprenal.00378.2014. Epub 2014 Jul 30.


Inhibition of Toll-Like Receptor 4 Signaling Mitigates Microvascular Loss but Not Fibrosis in a Model of Ischemic Acute Kidney Injury.

Dagher PC, Hato T, Mang HE, Plotkin Z, Richardson QV, Massad M, Mai E, Kuehl SE, Graham P, Kumar R, Sutton TA.

Int J Mol Sci. 2016 Apr 29;17(5). pii: E647. doi: 10.3390/ijms17050647.


Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release.

Grenz A, Kim JH, Bauerle JD, Tak E, Eltzschig HK, Clambey ET.

J Immunol. 2012 Nov 1;189(9):4566-73. doi: 10.4049/jimmunol.1201651. Epub 2012 Oct 1. Retraction in: J Immunol. 2017 Jul 1;199(1):363.


Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury.

Chen J, John R, Richardson JA, Shelton JM, Zhou XJ, Wang Y, Wu QQ, Hartono JR, Winterberg PD, Lu CY.

Kidney Int. 2011 Feb;79(3):288-99. doi: 10.1038/ki.2010.381. Epub 2010 Oct 6.


S1P(1)-selective agonist, SEW2871, ameliorates ischemic acute renal failure.

Lien YH, Yong KC, Cho C, Igarashi S, Lai LW.

Kidney Int. 2006 May;69(9):1601-8.


Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury.

Peng J, Li X, Zhang D, Chen JK, Su Y, Smith SB, Dong Z.

Kidney Int. 2015 Jan;87(1):137-50. doi: 10.1038/ki.2014.226. Epub 2014 Jun 25.


Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice.

Cha JJ, Hyun YY, Lee MH, Kim JE, Nam DH, Song HK, Kang YS, Lee JE, Kim HW, Han JY, Cha DR.

Endocrinology. 2013 Jun;154(6):2144-55. doi: 10.1210/en.2012-2080. Epub 2013 Apr 8.


TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure.

Ramesh G, Reeves WB.

Am J Physiol Renal Physiol. 2003 Oct;285(4):F610-8. Epub 2003 Jul 15.


Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury.

Chen J, Matzuk MM, Zhou XJ, Lu CY.

Kidney Int. 2012 Dec;82(11):1195-207. doi: 10.1038/ki.2012.268. Epub 2012 Aug 15.


Increased cellular senescence and vascular rarefaction exacerbate the progression of kidney fibrosis in aged mice following transient ischemic injury.

Clements ME, Chaber CJ, Ledbetter SR, Zuk A.

PLoS One. 2013 Aug 5;8(8):e70464. doi: 10.1371/journal.pone.0070464. Print 2013.


Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naïve myocardium but is essential for the development of late preconditioning.

Dawn B, Guo Y, Rezazadeh A, Wang OL, Stein AB, Hunt G, Varma J, Xuan YT, Wu WJ, Tan W, Zhu X, Bolli R.

J Mol Cell Cardiol. 2004 Jul;37(1):51-61.


Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemia-reperfusion injury.

Daemen MA, van de Ven MW, Heineman E, Buurman WA.

Transplantation. 1999 Mar 27;67(6):792-800.


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