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Items: 1 to 20 of 106


A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.

Prindle MJ, Schmitt MW, Parmeggiani F, Loeb LA.

J Biol Chem. 2013 Feb 22;288(8):5572-80. doi: 10.1074/jbc.M112.436410. Epub 2013 Jan 2.


Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.

Schmitt MW, Venkatesan RN, Pillaire MJ, Hoffmann JS, Sidorova JM, Loeb LA.

J Biol Chem. 2010 Oct 15;285(42):32264-72. doi: 10.1074/jbc.M110.147017. Epub 2010 Jul 13.


Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase delta.

Dieckman LM, Johnson RE, Prakash S, Washington MT.

Biochemistry. 2010 Aug 31;49(34):7344-50. doi: 10.1021/bi100556m.


Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.

Fortune JM, Pavlov YI, Welch CM, Johansson E, Burgers PM, Kunkel TA.

J Biol Chem. 2005 Aug 19;280(33):29980-7. Epub 2005 Jun 17.


DNA polymerase 3'→5' exonuclease activity: Different roles of the beta hairpin structure in family-B DNA polymerases.

Darmawan H, Harrison M, Reha-Krantz LJ.

DNA Repair (Amst). 2015 May;29:36-46. doi: 10.1016/j.dnarep.2015.02.014. Epub 2015 Feb 23.


Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta.

Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA.

J Biol Chem. 2006 Feb 17;281(7):4486-94. Epub 2005 Dec 12.


Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.

Brocas C, Charbonnier JB, Dhérin C, Gangloff S, Maloisel L.

DNA Repair (Amst). 2010 Oct 5;9(10):1098-111. doi: 10.1016/j.dnarep.2010.07.013. Epub 2010 Sep 1.


Defect of Fe-S cluster binding by DNA polymerase δ in yeast suppresses UV-induced mutagenesis, but enhances DNA polymerase ζ - dependent spontaneous mutagenesis.

Stepchenkova EI, Tarakhovskaya ER, Siebler HM, Pavlov YI.

DNA Repair (Amst). 2017 Jan;49:60-69. doi: 10.1016/j.dnarep.2016.11.004. Epub 2016 Dec 9.


Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase delta.

Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Nat Struct Mol Biol. 2009 Sep;16(9):979-86. doi: 10.1038/nsmb.1663. Epub 2009 Aug 30.


Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta.

Nick McElhinny SA, Stith CM, Burgers PM, Kunkel TA.

J Biol Chem. 2007 Jan 26;282(4):2324-32. Epub 2006 Nov 22.


The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.

Sanchez Garcia J, Ciufo LF, Yang X, Kearsey SE, MacNeill SA.

Nucleic Acids Res. 2004 Jun 1;32(10):3005-16. Print 2004.


Involvement of the yeast DNA polymerase delta in DNA repair in vivo.

Giot L, Chanet R, Simon M, Facca C, Faye G.

Genetics. 1997 Aug;146(4):1239-51.


DNA polymerase delta in DNA replication and genome maintenance.

Prindle MJ, Loeb LA.

Environ Mol Mutagen. 2012 Dec;53(9):666-82. doi: 10.1002/em.21745. Epub 2012 Oct 13. Review.


Evidence from mutational specificity studies that yeast DNA polymerases delta and epsilon replicate different DNA strands at an intracellular replication fork.

Karthikeyan R, Vonarx EJ, Straffon AF, Simon M, Faye G, Kunz BA.

J Mol Biol. 2000 Jun 2;299(2):405-19.


Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity.

Mertz TM, Sharma S, Chabes A, Shcherbakova PV.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2467-76. doi: 10.1073/pnas.1422934112. Epub 2015 Mar 31.

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