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Items: 1 to 20 of 81

1.

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C.

Cell Mol Life Sci. 2013 Jun;70(11):2015-29. doi: 10.1007/s00018-012-1244-6. Epub 2013 Jan 3.

PMID:
23283301
2.

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.

Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D.

Int J Biol Sci. 2008 Sep 5;4(5):291-9.

3.

Arsenic Induces Insulin Resistance in Mouse Adipocytes and Myotubes Via Oxidative Stress-Regulated Mitochondrial Sirt3-FOXO3a Signaling Pathway.

Padmaja Divya S, Pratheeshkumar P, Son YO, Vinod Roy R, Andrew Hitron J, Kim D, Dai J, Wang L, Asha P, Huang B, Xu M, Luo J, Zhang Z.

Toxicol Sci. 2015 Aug;146(2):290-300. doi: 10.1093/toxsci/kfv089. Epub 2015 May 15.

PMID:
25979314
4.

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1.

Sanchez AM, Csibi A, Raibon A, Cornille K, Gay S, Bernardi H, Candau R.

J Cell Biochem. 2012 Feb;113(2):695-710. doi: 10.1002/jcb.23399.

PMID:
22006269
5.

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression.

Ferber EC, Peck B, Delpuech O, Bell GP, East P, Schulze A.

Cell Death Differ. 2012 Jun;19(6):968-79. doi: 10.1038/cdd.2011.179. Epub 2011 Dec 2.

6.

Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.

Rangarajan P, Karthikeyan A, Lu J, Ling EA, Dheen ST.

Neuroscience. 2015 Dec 17;311:398-414. doi: 10.1016/j.neuroscience.2015.10.048. Epub 2015 Oct 30.

PMID:
26523980
7.

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.

White JP, Gao S, Puppa MJ, Sato S, Welle SL, Carson JA.

Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86. doi: 10.1016/j.mce.2012.10.019. Epub 2012 Oct 29.

8.

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis.

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y.

PLoS One. 2010 Jul 22;5(7):e11707. doi: 10.1371/journal.pone.0011707.

9.

Mitochondrial localization of the forkhead box class O transcription factor FOXO3a in brain.

Caballero-Caballero A, Engel T, Martinez-Villarreal J, Sanz-Rodriguez A, Chang P, Dunleavy M, Mooney CM, Jimenez-Mateos EM, Schindler CK, Henshall DC.

J Neurochem. 2013 Mar;124(6):749-56. doi: 10.1111/jnc.12133. Epub 2013 Jan 15.

10.

Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism.

Buler M, Aatsinki SM, Izzi V, Hakkola J.

PLoS One. 2012;7(11):e49863. doi: 10.1371/journal.pone.0049863. Epub 2012 Nov 16.

11.

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage.

Tseng AH, Shieh SS, Wang DL.

Free Radic Biol Med. 2013 Oct;63:222-34. doi: 10.1016/j.freeradbiomed.2013.05.002. Epub 2013 May 7.

PMID:
23665396
12.

Acute exercise induced mitochondrial H₂O₂ production in mouse skeletal muscle: association with p(66Shc) and FOXO3a signaling and antioxidant enzymes.

Wang P, Li CG, Qi Z, Cui D, Ding S.

Oxid Med Cell Longev. 2015;2015:536456. doi: 10.1155/2015/536456. Epub 2015 Mar 22.

13.

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.

Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP.

J Clin Invest. 2009 Sep;119(9):2758-71. doi: 10.1172/JCI39162. Epub 2009 Aug 3.

14.

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.

Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15983-7. Epub 2002 Nov 20.

15.

FoxO proteins' nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells.

Shukla S, Rizvi F, Raisuddin S, Kakkar P.

Free Radic Biol Med. 2014 Nov;76:185-99. doi: 10.1016/j.freeradbiomed.2014.07.039. Epub 2014 Aug 13.

PMID:
25128467
16.

Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.

Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, Teraguchi A, Lan F, Kikuchi A, Saito R, Tajima N, Shirasaki T, Matsugo S, Miyamoto K, Kaneko S, Takamura T.

J Biol Chem. 2014 Jan 3;289(1):335-45. doi: 10.1074/jbc.M113.479386. Epub 2013 Nov 20.

17.

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.

Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J.

Nature. 2009 Apr 23;458(7241):1056-60. doi: 10.1038/nature07813.

18.

Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3.

Lin L, Chen K, Abdel Khalek W, Ward JL 3rd, Yang H, Chabi B, Wrutniak-Cabello C, Tong Q.

PLoS One. 2014 Jan 15;9(1):e85636. doi: 10.1371/journal.pone.0085636. eCollection 2014.

19.

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle.

Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, Goodyear LJ, Tong Q.

Aging (Albany NY). 2009 Aug 15;1(9):771-83.

20.

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