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Items: 1 to 20 of 109


Sarcospan: a small protein with large potential for Duchenne muscular dystrophy.

Marshall JL, Crosbie-Watson RH.

Skelet Muscle. 2013 Jan 3;3(1):1. doi: 10.1186/2044-5040-3-1.


Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.

Marshall JL, Oh J, Chou E, Lee JA, Holmberg J, Burkin DJ, Crosbie-Watson RH.

Hum Mol Genet. 2015 Apr 1;24(7):2011-22. doi: 10.1093/hmg/ddu615. Epub 2014 Dec 11.


Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.

Marshall JL, Chou E, Oh J, Kwok A, Burkin DJ, Crosbie-Watson RH.

Hum Mol Genet. 2012 Oct 15;21(20):4378-93. Epub 2012 Jul 13.


Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.

Welser JV, Rooney JE, Cohen NC, Gurpur PB, Singer CA, Evans RA, Haines BA, Burkin DJ.

Am J Pathol. 2009 Oct;175(4):1545-54. doi: 10.2353/ajpath.2009.090052. Epub 2009 Sep 3.


The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy.

Marshall JL, Kwok Y, McMorran BJ, Baum LG, Crosbie-Watson RH.

FEBS J. 2013 Sep;280(17):4210-29. doi: 10.1111/febs.12295. Epub 2013 May 13. Review.


Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex.

Peter AK, Marshall JL, Crosbie RH.

J Cell Biol. 2008 Nov 3;183(3):419-27. doi: 10.1083/jcb.200808027.


Disrupted mechanical stability of the dystrophin-glycoprotein complex causes severe muscular dystrophy in sarcospan transgenic mice.

Peter AK, Miller G, Crosbie RH.

J Cell Sci. 2007 Mar 15;120(Pt 6):996-1008. Epub 2007 Feb 20.


Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy.

Parvatiyar MS, Marshall JL, Nguyen RT, Jordan MC, Richardson VA, Roos KP, Crosbie-Watson RH.

J Am Heart Assoc. 2015 Dec 23;4(12). pii: e002481. doi: 10.1161/JAHA.115.002481.


Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F.

Peter AK, Miller G, Capote J, DiFranco M, Solares-Pérez A, Wang EL, Heighway J, Coral-Vázquez RM, Vergara J, Crosbie-Watson RH.

Skelet Muscle. 2017 Jun 6;7(1):11. doi: 10.1186/s13395-017-0127-9.


Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.

Marshall JL, Holmberg J, Chou E, Ocampo AC, Oh J, Lee J, Peter AK, Martin PT, Crosbie-Watson RH.

J Cell Biol. 2012 Jun 25;197(7):1009-27. doi: 10.1083/jcb.201110032.


Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex.

Crosbie RH, Heighway J, Venzke DP, Lee JC, Campbell KP.

J Biol Chem. 1997 Dec 12;272(50):31221-4.


Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice.

Heller KN, Montgomery CL, Shontz KM, Clark KR, Mendell JR, Rodino-Klapac LR.

Hum Gene Ther. 2015 Oct;26(10):647-56. doi: 10.1089/hum.2015.062. Epub 2015 Aug 11.


Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle.

Cohn RD, Mayer U, Saher G, Herrmann R, van der Flier A, Sonnenberg A, Sorokin L, Voit T.

J Neurol Sci. 1999 Mar 1;163(2):140-52.


Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.

Burkin DJ, Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ.

J Cell Biol. 2001 Mar 19;152(6):1207-18.


Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophy in beta-sarcoglycan-deficient mice.

Araishi K, Sasaoka T, Imamura M, Noguchi S, Hama H, Wakabayashi E, Yoshida M, Hori T, Ozawa E.

Hum Mol Genet. 1999 Sep;8(9):1589-98.


Role of dystrophin isoforms and associated proteins in muscular dystrophy (review).

Culligan KG, Mackey AJ, Finn DM, Maguire PB, Ohlendieck K.

Int J Mol Med. 1998 Dec;2(6):639-48. Review.


Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin.

Rooney JE, Welser JV, Dechert MA, Flintoff-Dye NL, Kaufman SJ, Burkin DJ.

J Cell Sci. 2006 Jun 1;119(Pt 11):2185-95. Epub 2006 May 9.


Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.

D'Arcy CE, Feeney SJ, McLean CA, Gehrig SM, Lynch GS, Smith JE, Cowling BS, Mitchell CA, McGrath MJ.

Hum Mol Genet. 2014 Feb 1;23(3):618-36. doi: 10.1093/hmg/ddt449. Epub 2013 Sep 18.


Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.

Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L, Mayer U.

Hum Mol Genet. 2006 Mar 15;15(6):989-98. Epub 2006 Feb 13.


Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy.

Jasmin BJ, Angus LM, Bélanger G, Chakkalakal JV, Gramolini AO, Lunde JA, Stocksley MA, Thompson J.

J Physiol Paris. 2002 Jan-Mar;96(1-2):31-42. Review.


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