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Items: 1 to 20 of 112

1.

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.

Zhou L, Stewart G, Rideau E, Westwood NJ, Smith TK.

J Med Chem. 2013 Feb 14;56(3):796-806. doi: 10.1021/jm301215e. Epub 2013 Jan 15.

2.

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Sokolova AY, Wyllie S, Patterson S, Oza SL, Read KD, Fairlamb AH.

Antimicrob Agents Chemother. 2010 Jul;54(7):2893-900. doi: 10.1128/AAC.00332-10. Epub 2010 May 3.

3.

Evaluating 5-nitrofurans as trypanocidal agents.

Bot C, Hall BS, Alvarez G, Di Maio R, González M, Cerecetto H, Wilkinson SR.

Antimicrob Agents Chemother. 2013 Apr;57(4):1638-47. doi: 10.1128/AAC.02046-12. Epub 2013 Jan 18.

4.

6-Arylpyrazine-2-carboxamides: A New Core for Trypanosoma brucei Inhibitors.

Rahmani R, Ban K, Jones AJ, Ferrins L, Ganame D, Sykes ML, Avery VM, White KL, Ryan E, Kaiser M, Charman SA, Baell JB.

J Med Chem. 2015 Sep 10;58(17):6753-65. doi: 10.1021/acs.jmedchem.5b00438. Epub 2015 Aug 30.

PMID:
26247439
5.

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis.

Ferrins L, Rahmani R, Sykes ML, Jones AJ, Avery VM, Teston E, Almohaywi B, Yin J, Smith J, Hyland C, White KL, Ryan E, Campbell M, Charman SA, Kaiser M, Baell JB.

Eur J Med Chem. 2013 Aug;66:450-65. doi: 10.1016/j.ejmech.2013.05.007. Epub 2013 May 16.

PMID:
23831695
6.

Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors.

Steverding D.

Exp Parasitol. 2015 Apr-May;151-152:28-33. doi: 10.1016/j.exppara.2015.01.016. Epub 2015 Feb 4.

PMID:
25662707
7.

Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents.

Papadopoulou MV, Bloomer WD, Rosenzweig HS, Chatelain E, Kaiser M, Wilkinson SR, McKenzie C, Ioset JR.

J Med Chem. 2012 Jun 14;55(11):5554-65. doi: 10.1021/jm300508n. Epub 2012 May 23.

8.

Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

Wilkinson SR, Bot C, Kelly JM, Hall BS.

Curr Top Med Chem. 2011;11(16):2072-84. Review.

PMID:
21619510
9.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

Mol Med. 2000 Aug;6(8):660-9.

10.

Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.

Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Tulloch LB, Smith TK.

ChemMedChem. 2014 Nov;9(11):2548-56. doi: 10.1002/cmdc.201402272. Epub 2014 Aug 21.

11.

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.

Kelly JM, Taylor MC, Horn D, Loza E, Kalvinsh I, Björkling F.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1886-90. doi: 10.1016/j.bmcl.2012.01.072. Epub 2012 Jan 28.

12.

Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives.

Usuki T, Sato M, Hara S, Yoshimoto Y, Kondo R, Zimmermann S, Kaiser M, Brun R, Hamburger M, Adams M.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):794-8. doi: 10.1016/j.bmcl.2013.12.099. Epub 2014 Jan 2.

PMID:
24433861
13.

Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes.

Bruhn DF, Wyllie S, Rodríguez-Cortés A, Carrillo AK, Rakesh, Guy RK, Fairlamb AH, Lee RE.

J Antimicrob Chemother. 2016 Apr;71(4):956-63. doi: 10.1093/jac/dkv417. Epub 2015 Dec 18.

14.

Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei.

Vincent IM, Creek DJ, Burgess K, Woods DJ, Burchmore RJ, Barrett MP.

PLoS Negl Trop Dis. 2012;6(5):e1618. doi: 10.1371/journal.pntd.0001618. Epub 2012 May 1.

15.

Activity of diimidazoline amides against African trypanosomiasis.

Dong Y, Wang X, Cal M, Kaiser M, Vennerstrom JL.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):944-8. doi: 10.1016/j.bmcl.2013.12.064. Epub 2013 Dec 22.

16.

Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents.

Yang PY, Wang M, Li L, Wu H, He CY, Yao SQ.

Chemistry. 2012 May 21;18(21):6528-41. doi: 10.1002/chem.201103322. Epub 2012 Apr 4.

PMID:
22488888
17.

Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

Steverding D, Rushworth SA.

Exp Parasitol. 2017 Jul;178:45-50. doi: 10.1016/j.exppara.2017.05.006. Epub 2017 May 25.

PMID:
28552794
18.

Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi.

Velásquez AM, Francisco AI, Kohatsu AA, Silva FA, Rodrigues DF, Teixeira RG, Chiari BG, de Almeida MG, Isaac VL, Vargas MD, Cicarelli RM.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1707-10. doi: 10.1016/j.bmcl.2014.02.046. Epub 2014 Feb 28.

PMID:
24630563
19.

Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi.

Belluti F, Uliassi E, Veronesi G, Bergamini C, Kaiser M, Brun R, Viola A, Fato R, Michels PA, Krauth-Siegel RL, Cavalli A, Bolognesi ML.

ChemMedChem. 2014 Feb;9(2):371-82. doi: 10.1002/cmdc.201300399. Epub 2014 Jan 8.

PMID:
24403089
20.

Drug resistance in human African trypanosomiasis.

Barrett MP, Vincent IM, Burchmore RJ, Kazibwe AJ, Matovu E.

Future Microbiol. 2011 Sep;6(9):1037-47. doi: 10.2217/fmb.11.88. Review.

PMID:
21958143

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