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Items: 1 to 20 of 106

1.

Protein kinase Cβ is required for lupus development in Sle mice.

Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, Tipton C, Lund F, Schwartz G, Goldman B, Mohan C, Mehta K, Mehta M, Leitgets M, Sanz I, Chen L.

Arthritis Rheum. 2013 Apr;65(4):1022-31. doi: 10.1002/art.37825.

2.

Inhibition of protein kinase Cbeta by enzastaurin enhances radiation cytotoxicity in pancreatic cancer.

Spalding AC, Watson R, Davis ME, Kim AC, Lawrence TS, Ben-Josef E.

Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6827-33.

3.

PKK deficiency in B cells prevents lupus development in Sle lupus mice.

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L.

Immunol Lett. 2017 May;185:1-11. doi: 10.1016/j.imlet.2017.03.002. Epub 2017 Mar 6.

PMID:
28274793
4.

The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.

Graff JR, McNulty AM, Hanna KR, Konicek BW, Lynch RL, Bailey SN, Banks C, Capen A, Goode R, Lewis JE, Sams L, Huss KL, Campbell RM, Iversen PW, Neubauer BL, Brown TJ, Musib L, Geeganage S, Thornton D.

Cancer Res. 2005 Aug 15;65(16):7462-9.

5.

Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.

Khass M, Schelonka RL, Liu CR, Elgavish A, Morel L, Burrows PD, Schroeder HW Jr.

Autoimmunity. 2017 Feb;50(1):42-51. doi: 10.1080/08916934.2016.1272597.

6.

Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking.

Venkataraman C, Chen XC, Na S, Lee L, Neote K, Tan SL.

Immunol Lett. 2006 May 15;105(1):83-9. Epub 2006 Feb 20.

PMID:
16564096
9.

[Role of PKCbeta in the malignant tumors and enzastaurin, a PKCbeta inhibitor].

Li XY, Chen XG.

Yao Xue Xue Bao. 2009 May;44(5):449-55. Review. Chinese.

PMID:
19618717
10.

Protein kinase C-beta inhibitor enzastaurin (LY317615.HCI) enhances radiation control of murine breast cancer in an orthotopic model of bone metastasis.

Dudek AZ, Zwolak P, Jasinski P, Terai K, Gallus NJ, Ericson ME, Farassati F.

Invest New Drugs. 2008 Feb;26(1):13-24. Epub 2007 Sep 6.

PMID:
17805485
11.

IL-10 regulation of lupus in the NZM2410 murine model.

Blenman KR, Duan B, Xu Z, Wan S, Atkinson MA, Flotte TR, Croker BP, Morel L.

Lab Invest. 2006 Nov;86(11):1136-48. Epub 2006 Aug 21.

12.

Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinase.

Mina-Osorio P, LaStant J, Keirstead N, Whittard T, Ayala J, Stefanova S, Garrido R, Dimaano N, Hilton H, Giron M, Lau KY, Hang J, Postelnek J, Kim Y, Min S, Patel A, Woods J, Ramanujam M, DeMartino J, Narula S, Xu D.

Arthritis Rheum. 2013 Sep;65(9):2380-91. doi: 10.1002/art.38047.

13.

PKCbeta modulates ischemia-reperfusion injury in the heart.

Kong L, Andrassy M, Chang JS, Huang C, Asai T, Szabolcs MJ, Homma S, Liu R, Zou YS, Leitges M, Yan SD, Ramasamy R, Schmidt AM, Yan SF.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1862-70. doi: 10.1152/ajpheart.01346.2007. Epub 2008 Feb 1.

PMID:
18245560
14.

Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia.

Moreau AS, Jia X, Ngo HT, Leleu X, O'Sullivan G, Alsayed Y, Leontovich A, Podar K, Kutok J, Daley J, Lazo-Kallanian S, Hatjiharissi E, Raab MS, Xu L, Treon SP, Hideshima T, Anderson KC, Ghobrial IM.

Blood. 2007 Jun 1;109(11):4964-72. Epub 2007 Feb 6.

15.

Genetic dissection of systemic lupus erythematosus pathogenesis: evidence for functional expression of Sle3/5 by non-T cells.

Sobel ES, Morel L, Baert R, Mohan C, Schiffenbauer J, Wakeland EK.

J Immunol. 2002 Oct 1;169(7):4025-32.

16.

Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.

Suárez-Fueyo A, Rojas JM, Cariaga AE, García E, Steiner BH, Barber DF, Puri KD, Carrera AC.

J Immunol. 2014 Jul 15;193(2):544-54. doi: 10.4049/jimmunol.1400350. Epub 2014 Jun 16.

17.

PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

Holler C, Piñón JD, Denk U, Heyder C, Hofbauer S, Greil R, Egle A.

Blood. 2009 Mar 19;113(12):2791-4. doi: 10.1182/blood-2008-06-160713. Epub 2009 Jan 23.

18.
19.

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus.

Hutcheson J, Vanarsa K, Bashmakov A, Grewal S, Sajitharan D, Chang BY, Buggy JJ, Zhou XJ, Du Y, Satterthwaite AB, Mohan C.

Arthritis Res Ther. 2012 Nov 8;14(6):R243. doi: 10.1186/ar4086.

20.

Normalization of CD4+ T cell metabolism reverses lupus.

Yin Y, Choi SC, Xu Z, Perry DJ, Seay H, Croker BP, Sobel ES, Brusko TM, Morel L.

Sci Transl Med. 2015 Feb 11;7(274):274ra18. doi: 10.1126/scitranslmed.aaa0835.

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