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Items: 1 to 20 of 104

1.

Synthesis and biological evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted benzylpiperazine moieties as positive inotropic agents.

Wu Y, Sun LP, Ma LX, Che J, Song MX, Cui X, Piao HR.

Chem Biol Drug Des. 2013 May;81(5):591-9. doi: 10.1111/cbdd.12101. Epub 2013 Mar 26.

PMID:
23279930
2.

Synthesis and positive inotropic evaluation of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties.

Ma LX, Cui BR, Wu Y, Liu JC, Cui X, Liu LP, Piao HR.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1737-41. doi: 10.1016/j.bmcl.2014.02.040. Epub 2014 Mar 3.

PMID:
24636107
3.

Synthesis of 2-(4-substitutedbenzyl-[1,4]diazepan-1-yl)-n-(1-methyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides as inotropic agents.

Ye BJ, Liu XK, Jiang SM, Cui X, Piao HR.

Chem Biol Drug Des. 2011 Jan;77(1):98-103. doi: 10.1111/j.1747-0285.2010.01057.x. Epub 2010 Nov 26.

PMID:
21114630
4.

Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties.

Wu Y, Ma LX, Niu TW, Cui X, Piao HR.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4229-32. doi: 10.1016/j.bmcl.2012.05.049. Epub 2012 May 18.

PMID:
22672796
5.

Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives.

Zhang CB, Cui X, Hong L, Quan ZS, Piao HR.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4606-9. doi: 10.1016/j.bmcl.2008.07.026. Epub 2008 Jul 12.

PMID:
18657421
6.

Synthesis and positive inotropic evaluation of (E)-2-(4-cinnamylpiperazin-1-yl)-N-(1-substituted-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides.

Wu Y, Ma LX, Niu TW, Meng FL, Cui X, Piao HR.

Arch Pharm (Weinheim). 2012 Dec;345(12):980-8. doi: 10.1002/ardp.201200159. Epub 2012 Sep 26.

PMID:
23015381
7.

Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinolin-7-yl)-acetamides.

Li JY, Cui X, Liu XK, Hong L, Quan ZS, Piao HR.

Arch Pharm (Weinheim). 2008 Dec;341(12):794-9. doi: 10.1002/ardp.200800132.

PMID:
19006092
8.

Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.

Yang K, Sun LP, Liu JY, Cui X, Piao HR.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4464-7. doi: 10.1016/j.bmcl.2010.06.046. Epub 2010 Jun 15.

PMID:
20591664
9.
10.

Synthesis and Positive Inotropic Activity of [1,2,4]Triazolo[4,3-a] Quinoxaline Derivatives Bearing Substituted Benzylpiperazine and Benzoylpiperazine Moieties.

Liu XK, Ma LX, Wei ZY, Cui X, Zhan S, Yin XM, Piao HR.

Molecules. 2017 Feb 11;22(2). pii: E273. doi: 10.3390/molecules22020273.

11.

Synthesis of 2-(4-substitutedmethylpiperazin-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.

Liu XK, Cui X, Hong L, Sun LP, Quan ZS, Piao HR.

Eur J Med Chem. 2009 Jul;44(7):3027-31. doi: 10.1016/j.ejmech.2008.08.006. Epub 2008 Aug 29.

PMID:
18824278
12.

Synthesis and inotropic evaluation of 1-substituted-N-(4,5-dihydro-1-methyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)piperidine-4-carboxamides.

Liu JY, Yu HL, Quan ZS, Cui X, Piao HR.

Bioorg Med Chem Lett. 2009 May 1;19(9):2392-5. doi: 10.1016/j.bmcl.2009.03.089. Epub 2009 Mar 26.

PMID:
19356931
13.

Synthesis of new triazole acetamides with inotropic effects.

Wu Y, Ma LX, Sun LP, Song MX, Cui X, Piao HR.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):757-60. doi: 10.1016/j.bmcl.2012.11.078. Epub 2012 Dec 1.

PMID:
23265872
14.

Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides.

Jiang SM, Ye BJ, Liu XK, Zhang TY, Cui X, Piao HR.

Arch Pharm (Weinheim). 2010 Nov;343(11-12):700-5. doi: 10.1002/ardp.201000032.

PMID:
21110340
15.

The progress towards the development of DHQO derivatives and related analogues with inotropic effects.

Wu Y, Piao HR.

Mini Rev Med Chem. 2013 Oct;13(12):1801-11. Review.

PMID:
24032511
16.

Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones.

Hong L, Gong GH, Yu L, Song MX, Cui X, Quan ZS.

Arch Pharm Res. 2013 Nov;36(11):1338-44. doi: 10.1007/s12272-013-0203-6. Epub 2013 Aug 6.

PMID:
23918646
17.

[Potential cardiotonics. 14. Synthesis and in vitro positive inotropic actions of 4-morpholino-5-(4-pyridinyl)pyridine derivatives].

Hagen V, Hagen A, Krause EG, Klauschenz E.

Pharmazie. 1992 Oct;47(10):767-9. German.

PMID:
1480654
18.

Synthesis and positive inotropic effects of 1-acyl-5,6-diethoxy-2-methylthiobenzimidazoles.

Garaliené V, Labanauskas L, Brukstus A, Dauksas V.

Arzneimittelforschung. 1998 Dec;48(12):1137-42.

PMID:
9893927
19.

Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.

Dorigo P, Fraccarollo D, Santostasi G, Maragno I, Floreani M, Borea PA, Mosti L, Sansebastiano L, Fossa P, Orsini F, Benetollo F, Bombieri G.

J Med Chem. 1996 Sep 13;39(19):3671-83.

PMID:
8809156
20.

Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species.

Alousi AA, Stankus GP, Stuart JC, Walton LH.

J Cardiovasc Pharmacol. 1983 Sep-Oct;5(5):804-11.

PMID:
6195468

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