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Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.

Tao J, Han J, Wu H, Hu X, Deng J, Fleming J, Maxwell A, Bi L, Mi K.

Nucleic Acids Res. 2013 Feb 1;41(4):2370-81. doi: 10.1093/nar/gks1351. Epub 2012 Dec 28.


The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.

Mérens A, Matrat S, Aubry A, Lascols C, Jarlier V, Soussy CJ, Cavallo JD, Cambau E.

J Bacteriol. 2009 Mar;191(5):1587-94. doi: 10.1128/JB.01205-08. Epub 2008 Dec 5.


A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

Hegde SS, Vetting MW, Roderick SL, Mitchenall LA, Maxwell A, Takiff HE, Blanchard JS.

Science. 2005 Jun 3;308(5727):1480-3.


Mechanisms of fluoroquinolone resistance in Mycobacterium tuberculosis.

Zhang YJ, Li XJ, Mi KX.

Yi Chuan. 2016 Oct 20;38(10):918-927. Review.


Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K.

J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4.


Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis.

Chatterji M, Unniraman S, Mahadevan S, Nagaraja V.

J Antimicrob Chemother. 2001 Oct;48(4):479-85.


Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.

Aldred KJ, Blower TR, Kerns RJ, Berger JM, Osheroff N.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E839-46. doi: 10.1073/pnas.1525055113. Epub 2016 Jan 20.


Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.

Malik M, Marks KR, Mustaev A, Zhao X, Chavda K, Kerns RJ, Drlica K.

Antimicrob Agents Chemother. 2011 May;55(5):2335-43. doi: 10.1128/AAC.00033-11. Epub 2011 Mar 7.


Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives.

Sriram D, Bal TR, Yogeeswari P, Radha DR, Nagaraja V.

J Gen Appl Microbiol. 2006 Aug;52(4):195-200.


Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.

Sengupta S, Nagaraja V.

FEMS Microbiol Lett. 2008 Feb;279(1):40-7. doi: 10.1111/j.1574-6968.2007.01005.x.


Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme.

Sengupta S, Ghosh S, Nagaraja V.

Microbiology. 2008 Sep;154(Pt 9):2796-803. doi: 10.1099/mic.0.2008/020933-0.


Intrinsic resistance of Mycobacterium smegmatis to fluoroquinolones may be influenced by new pentapeptide protein MfpA.

Montero C, Mateu G, Rodriguez R, Takiff H.

Antimicrob Agents Chemother. 2001 Dec;45(12):3387-92.


Biochemistry. Protein that mimics DNA helps tuberculosis bacteria resist antibiotics.

Ferber D.

Science. 2005 Jun 3;308(5727):1393. No abstract available.


A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.

Manjunatha UH, Maxwell A, Nagaraja V.

Nucleic Acids Res. 2005 Jun 1;33(10):3085-94. Print 2005.


Emergence of fluoroquinolone-resistant Propionibacterium acnes caused by amino acid substitutions of DNA gyrase but not DNA topoisomerase IV.

Nakase K, Sakuma Y, Nakaminami H, Noguchi N.

Anaerobe. 2016 Dec;42:166-171. doi: 10.1016/j.anaerobe.2016.10.012. Epub 2016 Oct 26.


Pentapeptide repeat proteins.

Vetting MW, Hegde SS, Fajardo JE, Fiser A, Roderick SL, Takiff HE, Blanchard JS.

Biochemistry. 2006 Jan 10;45(1):1-10.


DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis.

Pantel A, Petrella S, Matrat S, Brossier F, Bastian S, Reitter D, Jarlier V, Mayer C, Aubry A.

Antimicrob Agents Chemother. 2011 Oct;55(10):4524-9. doi: 10.1128/AAC.00707-11. Epub 2011 Jul 18.


The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosis.

Mayer C, Takiff H.

Microbiol Spectr. 2014 Aug;2(4):MGM2-0009-2013. doi: 10.1128/microbiolspec.MGM2-0009-2013. Review.


A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.

Maruri F, Sterling TR, Kaiga AW, Blackman A, van der Heijden YF, Mayer C, Cambau E, Aubry A.

J Antimicrob Chemother. 2012 Apr;67(4):819-31. doi: 10.1093/jac/dkr566. Epub 2012 Jan 25. Review.

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