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Items: 1 to 20 of 107

1.

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.

Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.

J Am Soc Nephrol. 2013 Jan;24(1):100-12. doi: 10.1681/ASN.2012050490.

2.

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.

Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J.

J Am Soc Nephrol. 2008 Mar;19(3):469-76. doi: 10.1681/ASN.2006090985. Epub 2008 Jan 30.

3.

Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.

Natoli TA, Gareski TC, Dackowski WR, Smith L, Bukanov NO, Russo RJ, Husson H, Matthews D, Piepenhagen P, Ibraghimov-Beskrovnaya O.

Am J Physiol Renal Physiol. 2008 Jan;294(1):F73-83. Epub 2007 Oct 10.

PMID:
17928412
4.

Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease.

Smith LA, Bukanov NO, Husson H, Russo RJ, Barry TC, Taylor AL, Beier DR, Ibraghimov-Beskrovnaya O.

J Am Soc Nephrol. 2006 Oct;17(10):2821-31. Epub 2006 Aug 23.

5.

Defects in ciliary localization of Nek8 is associated with cystogenesis.

Trapp ML, Galtseva A, Manning DK, Beier DR, Rosenblum ND, Quarmby LM.

Pediatr Nephrol. 2008 Mar;23(3):377-87. doi: 10.1007/s00467-007-0692-y. Epub 2008 Jan 9.

PMID:
18189147
6.

Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.

Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, Filhol E, Niel O, Silbermann F, Lebreton C, Collardeau-Frachon S, Rouvet I, Alessandri JL, Devisme L, Dieux-Coeslier A, Cordier MP, Capri Y, Khung-Savatovsky S, Sigaudy S, Salomon R, Antignac C, Gubler MC, Benmerah A, Terzi F, Attié-Bitach T, Jeanpierre C, Saunier S.

PLoS Genet. 2016 Mar 11;12(3):e1005894. doi: 10.1371/journal.pgen.1005894. eCollection 2016 Mar.

7.

Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.

Frank V, Habbig S, Bartram MP, Eisenberger T, Veenstra-Knol HE, Decker C, Boorsma RA, Göbel H, Nürnberg G, Griessmann A, Franke M, Borgal L, Kohli P, Völker LA, Dötsch J, Nürnberg P, Benzing T, Bolz HJ, Johnson C, Gerkes EH, Schermer B, Bergmann C.

Hum Mol Genet. 2013 Jun 1;22(11):2177-85. doi: 10.1093/hmg/ddt070. Epub 2013 Feb 14.

PMID:
23418306
8.

The ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafish.

Fukui H, Shiba D, Asakawa K, Kawakami K, Yokoyama T.

FEBS Lett. 2012 Jul 30;586(16):2273-9. doi: 10.1016/j.febslet.2012.05.064. Epub 2012 Jun 8.

9.

NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis.

Otto EA, Trapp ML, Schultheiss UT, Helou J, Quarmby LM, Hildebrandt F.

J Am Soc Nephrol. 2008 Mar;19(3):587-92. doi: 10.1681/ASN.2007040490. Epub 2008 Jan 16.

10.

The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes.

Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH.

PLoS Genet. 2011 Apr;7(4):e1001361. doi: 10.1371/journal.pgen.1001361. Epub 2011 Apr 7.

11.

A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR.

Development. 2002 Dec;129(24):5839-46.

12.

NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.

Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.

Mol Cell. 2013 Aug 22;51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.

13.

Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis.

Bisgrove BW, Snarr BS, Emrazian A, Yost HJ.

Dev Biol. 2005 Nov 15;287(2):274-88. Epub 2005 Oct 7.

14.

ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning.

Czarnecki PG, Gabriel GC, Manning DK, Sergeev M, Lemke K, Klena NT, Liu X, Chen Y, Li Y, San Agustin JT, Garnaas MK, Francis RJ, Tobita K, Goessling W, Pazour GJ, Lo CW, Beier DR, Shah JV.

Nat Commun. 2015 Jan 20;6:6023. doi: 10.1038/ncomms7023.

15.

A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8.

McCooke JK, Appels R, Barrero RA, Ding A, Ozimek-Kulik JE, Bellgard MI, Morahan G, Phillips JK.

BMC Genomics. 2012 Aug 16;13:393. doi: 10.1186/1471-2164-13-393.

16.
17.

Nek1 and TAZ interact to maintain normal levels of polycystin 2.

Yim H, Sung CK, You J, Tian Y, Benjamin T.

J Am Soc Nephrol. 2011 May;22(5):832-7. doi: 10.1681/ASN.2010090992. Epub 2011 Apr 7.

18.

The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry.

Endicott SJ, Basu B, Khokha M, Brueckner M.

Development. 2015 Dec 1;142(23):4068-79. doi: 10.1242/dev.126953. Epub 2015 Oct 22.

19.

Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin.

Kim I, Ding T, Fu Y, Li C, Cui L, Li A, Lian P, Liang D, Wang DW, Guo C, Ma J, Zhao P, Coffey RJ, Zhan Q, Wu G.

J Am Soc Nephrol. 2009 Dec;20(12):2556-69. doi: 10.1681/ASN.2009030271. Epub 2009 Nov 25.

20.

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.

Zalli D, Bayliss R, Fry AM.

Hum Mol Genet. 2012 Mar 1;21(5):1155-71. doi: 10.1093/hmg/ddr544. Epub 2011 Nov 21.

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