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Items: 1 to 20 of 83

1.

A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31.

Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS.

Curr Biol. 2013 Jan 21;23(2):162-7. doi: 10.1016/j.cub.2012.11.049. Epub 2012 Dec 27.

2.

The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.

Schäker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J.

J Biol Chem. 2015 Mar 6;290(10):6408-18. doi: 10.1074/jbc.M114.633701. Epub 2015 Jan 13.

3.

Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo.

Elliott MR, Zheng S, Park D, Woodson RI, Reardon MA, Juncadella IJ, Kinchen JM, Zhang J, Lysiak JJ, Ravichandran KS.

Nature. 2010 Sep 16;467(7313):333-7. doi: 10.1038/nature09356.

4.

ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion.

Jarzynka MJ, Hu B, Hui KM, Bar-Joseph I, Gu W, Hirose T, Haney LB, Ravichandran KS, Nishikawa R, Cheng SY.

Cancer Res. 2007 Aug 1;67(15):7203-11.

5.

The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.

Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE.

Dev Biol. 2010 Jun 15;342(2):146-56. doi: 10.1016/j.ydbio.2010.03.019. Epub 2010 Mar 27.

6.

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling.

Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, Côté JF.

Mol Biol Cell. 2008 Nov;19(11):4837-51. doi: 10.1091/mbc.E08-04-0345. Epub 2008 Sep 3.

7.

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.

Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3305-10. doi: 10.1073/pnas.1113512109. Epub 2012 Feb 13.

8.

ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis.

Elliott MR, Ravichandran KS.

Ann N Y Acad Sci. 2010 Oct;1209:30-6. doi: 10.1111/j.1749-6632.2010.05764.x.

PMID:
20958313
9.

Essential role of Elmo1 in Dock2-dependent lymphocyte migration.

Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR.

J Immunol. 2014 Jun 15;192(12):6062-70. doi: 10.4049/jimmunol.1303348. Epub 2014 May 12.

10.

Elmo1 inhibits ubiquitylation of Dock180.

Makino Y, Tsuda M, Ichihara S, Watanabe T, Sakai M, Sawa H, Nagashima K, Hatakeyama S, Tanaka S.

J Cell Sci. 2006 Mar 1;119(Pt 5):923-32.

11.

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration.

Grimsley CM, Kinchen JM, Tosello-Trampont AC, Brugnera E, Haney LB, Lu M, Chen Q, Klingele D, Hengartner MO, Ravichandran KS.

J Biol Chem. 2004 Feb 13;279(7):6087-97. Epub 2003 Nov 24.

12.

Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1.

Yang C, Sorokin A.

Cell Signal. 2011 Jan;23(1):99-104. doi: 10.1016/j.cellsig.2010.08.008. Epub 2010 Aug 21.

13.

Characterization of a novel interaction between ELMO1 and ERM proteins.

Grimsley CM, Lu M, Haney LB, Kinchen JM, Ravichandran KS.

J Biol Chem. 2006 Mar 3;281(9):5928-37. Epub 2005 Dec 23.

14.

The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.

Epting D, Wendik B, Bennewitz K, Dietz CT, Driever W, Kroll J.

Circ Res. 2010 Jul 9;107(1):45-55. doi: 10.1161/CIRCRESAHA.109.213983. Epub 2010 May 13.

15.

Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria.

Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2136-41. doi: 10.1073/pnas.1014775108. Epub 2011 Jan 18.

16.

Elmo1 helps dock180 to regulate Rac1 activity and cell migration of ovarian cancer.

Wang J, Dai JM, Che YL, Gao YM, Peng HJ, Liu B, Wang H, Linghu H.

Int J Gynecol Cancer. 2014 Jun;24(5):844-50. doi: 10.1097/IGC.0000000000000137.

PMID:
24819662
17.

The C-terminal polyproline-containing region of ELMO contributes to an increase in the life-time of the ELMO-DOCK complex.

Sévajol M, Reiser JB, Chouquet A, Pérard J, Ayala I, Gans P, Kleman JP, Housset D.

Biochimie. 2012 Mar;94(3):823-8. doi: 10.1016/j.biochi.2011.11.014. Epub 2011 Dec 6.

PMID:
22177965
18.

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex.

Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS.

Nat Cell Biol. 2002 Aug;4(8):574-82.

PMID:
12134158
19.

Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells.

Tosello-Trampont AC, Kinchen JM, Brugnera E, Haney LB, Hengartner MO, Ravichandran KS.

Cell Death Differ. 2007 May;14(5):963-72. Epub 2007 Feb 16.

20.

Identification of a novel protein interaction between Elmo1 and Cdc27.

Lee J, Moon B, Lee DH, Lee G, Park D.

Biochem Biophys Res Commun. 2016 Mar 18;471(4):497-502. doi: 10.1016/j.bbrc.2016.02.046. Epub 2016 Feb 13.

PMID:
26882976

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