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Items: 1 to 20 of 103

1.

The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.

Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P.

Immunity. 2013 Jan 24;38(1):106-18. doi: 10.1016/j.immuni.2012.11.004. Epub 2012 Dec 27.

2.

25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.

Doms A, Sanabria T, Hansen JN, Altan-Bonnet N, Holm GH.

J Virol. 2018 Aug 29;92(18). pii: e01047-18. doi: 10.1128/JVI.01047-18. Print 2018 Sep 15.

3.

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.

Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G.

Immunity. 2013 Jan 24;38(1):92-105. doi: 10.1016/j.immuni.2012.11.005. Epub 2012 Dec 27.

4.

Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis.

Lu H, Talbot S, Robertson KA, Watterson S, Forster T, Roy D, Ghazal P.

Steroids. 2015 Jul;99(Pt B):219-29. doi: 10.1016/j.steroids.2015.02.022. Epub 2015 Mar 7.

5.

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.

Gold ES, Diercks AH, Podolsky I, Podyminogin RL, Askovich PS, Treuting PM, Aderem A.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10666-71. doi: 10.1073/pnas.1404271111. Epub 2014 Jul 3.

6.

Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.

Xiang Y, Tang JJ, Tao W, Cao X, Song BL, Zhong J.

J Virol. 2015 Jul;89(13):6805-16. doi: 10.1128/JVI.00587-15. Epub 2015 Apr 22.

7.

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation.

Shrivastava-Ranjan P, Bergeron É, Chakrabarti AK, Albariño CG, Flint M, Nichol ST, Spiropoulou CF.

MBio. 2016 Dec 20;7(6). pii: e01808-16. doi: 10.1128/mBio.01808-16.

8.

Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.

Pereiro P, Forn-Cuní G, Dios S, Coll J, Figueras A, Novoa B.

Antiviral Res. 2017 Sep;145:146-159. doi: 10.1016/j.antiviral.2017.08.003. Epub 2017 Aug 5.

PMID:
28789986
9.

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK.

J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4.

10.

Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity.

Singaravelu R, Srinivasan P, Pezacki JP.

Can J Microbiol. 2015 Aug;61(8):521-30. doi: 10.1139/cjm-2015-0292. Epub 2015 Jun 10. Review.

11.

Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-γ-induced inflammatory responses and LXR-dependent gene expression.

Pascual-García M, Rué L, León T, Julve J, Carbó JM, Matalonga J, Auer H, Celada A, Escolà-Gil JC, Steffensen KR, Pérez-Navarro E, Valledor AF.

J Immunol. 2013 Jun 15;190(12):6520-32. doi: 10.4049/jimmunol.1201393. Epub 2013 May 17.

12.

Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.

Park K, Scott AL.

J Leukoc Biol. 2010 Dec;88(6):1081-7. doi: 10.1189/jlb.0610318. Epub 2010 Aug 10.

13.

Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.

Blanc M, Hsieh WY, Robertson KA, Watterson S, Shui G, Lacaze P, Khondoker M, Dickinson P, Sing G, Rodríguez-Martín S, Phelan P, Forster T, Strobl B, Müller M, Riemersma R, Osborne T, Wenk MR, Angulo A, Ghazal P.

PLoS Biol. 2011 Mar;9(3):e1000598. doi: 10.1371/journal.pbio.1000598. Epub 2011 Mar 8.

14.

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.

Chen Y, Wang S, Yi Z, Tian H, Aliyari R, Li Y, Chen G, Liu P, Zhong J, Chen X, Du P, Su L, Qin FX, Deng H, Cheng G.

Sci Rep. 2014 Dec 3;4:7242. doi: 10.1038/srep07242.

15.

Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.

Wang J, Zeng L, Zhang L, Guo ZZ, Lu SF, Ming SL, Li GL, Wan B, Tian KG, Yang GY, Chu BB.

J Gen Virol. 2017 Jun;98(6):1467-1476. doi: 10.1099/jgv.0.000797. Epub 2017 Jun 20.

PMID:
28631596
16.

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.

Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E.

Hepatology. 2015 Sep;62(3):702-14. doi: 10.1002/hep.27913. Epub 2015 Jul 28.

PMID:
25999047
17.

25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.

Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1369-79. doi: 10.1152/ajpendo.90555.2008. Epub 2008 Oct 14.

18.

RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

Tuong ZK, Lau P, Du X, Condon ND, Goode JM, Oh TG, Yeo JC, Muscat GE, Stow JL.

PLoS One. 2016 Jan 26;11(1):e0147179. doi: 10.1371/journal.pone.0147179. eCollection 2016.

19.

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon.

Reboldi A, Dang EV, McDonald JG, Liang G, Russell DW, Cyster JG.

Science. 2014 Aug 8;345(6197):679-84. doi: 10.1126/science.1254790.

20.

Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.

Bai Q, Xu L, Kakiyama G, Runge-Morris MA, Hylemon PB, Yin L, Pandak WM, Ren S.

Atherosclerosis. 2011 Feb;214(2):350-6. doi: 10.1016/j.atherosclerosis.2010.11.021. Epub 2010 Nov 26.

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