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Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy.

Coppini R, Ferrantini C, Yao L, Fan P, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Yacoub M, Olivotto I, Belardinelli L, Poggesi C, Cerbai E, Mugelli A.

Circulation. 2013 Feb 5;127(5):575-84. doi: 10.1161/CIRCULATIONAHA.112.134932. Epub 2012 Dec 27.


Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.

Coppini R, Mazzoni L, Ferrantini C, Gentile F, Pioner JM, Laurino A, Santini L, Bargelli V, Rotellini M, Bartolucci G, Crocini C, Sacconi L, Tesi C, Belardinelli L, Tardiff J, Mugelli A, Olivotto I, Cerbai E, Poggesi C.

Circ Heart Fail. 2017 Mar;10(3). pii: e003565. doi: 10.1161/CIRCHEARTFAILURE.116.003565.


Electrophysiologic characteristics and pharmacologic response of human cardiomyocytes isolated from a patient with hypertrophic cardiomyopathy.

Barajas-Martínez H, Hu D, Goodrow RJ Jr, Joyce F, Antzelevitch C.

Pacing Clin Electrophysiol. 2013 Dec;36(12):1512-5. doi: 10.1111/pace.12227. Epub 2013 Oct 1.


Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

Flenner F, Friedrich FW, Ungeheuer N, Christ T, Geertz B, Reischmann S, Wagner S, Stathopoulou K, Söhren KD, Weinberger F, Schwedhelm E, Cuello F, Maier LS, Eschenhagen T, Carrier L.

Cardiovasc Res. 2016 Jan 1;109(1):90-102. doi: 10.1093/cvr/cvv247. Epub 2015 Nov 3.


Distinctive electrophysiological characteristics of right ventricular out-flow tract cardiomyocytes.

Lu YY, Chung FP, Chen YC, Tsai CF, Kao YH, Chao TF, Huang JH, Chen SA, Chen YJ.

J Cell Mol Med. 2014 Aug;18(8):1540-8. doi: 10.1111/jcmm.12329. Epub 2014 Jun 9.


Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences.

Maltsev VA, Reznikov V, Undrovinas NA, Sabbah HN, Undrovinas A.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1597-608. doi: 10.1152/ajpheart.00484.2007. Epub 2008 Jan 18.


Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.

Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.

J Mol Cell Cardiol. 2013 Aug;61:111-22. doi: 10.1016/j.yjmcc.2013.03.021. Epub 2013 Apr 6.


Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

Yao L, Fan P, Jiang Z, Viatchenko-Karpinski S, Wu Y, Kornyeyev D, Hirakawa R, Budas GR, Rajamani S, Shryock JC, Belardinelli L.

Am J Physiol Cell Physiol. 2011 Sep;301(3):C577-86. doi: 10.1152/ajpcell.00125.2011. Epub 2011 Jun 15.


Response to letter regarding article, "Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy".

Coppini R, Ferrantini C, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Poggesi C, Cerbai E, Mugelli A, Yao L, Fan P, Belardinelli L, Yacoub M, Olivotto I.

Circulation. 2013 Sep 3;128(10):e157. doi: 10.1161/CIRCULATIONAHA.113.004016. No abstract available.


Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current.

Undrovinas AI, Belardinelli L, Undrovinas NA, Sabbah HN.

J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S169-S177.


Letter by Sikkel et al regarding article, "Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy".

Sikkel MB, MacLeod KT, Gordon F.

Circulation. 2013 Sep 3;128(10):e156. doi: 10.1161/CIRCULATIONAHA.113.003070. No abstract available.


Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schöndube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L, Maier LS.

J Mol Cell Cardiol. 2008 Jul;45(1):32-43. doi: 10.1016/j.yjmcc.2008.03.006. Epub 2008 Mar 14.


Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner.

Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, Ungeheuer N, Herting J, Shah AM, Maier LS, Sossalla S, Unsöld B.

J Mol Cell Cardiol. 2014 Nov;76:94-105. doi: 10.1016/j.yjmcc.2014.08.016. Epub 2014 Aug 27.


Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine.

Lindegger N, Hagen BM, Marks AR, Lederer WJ, Kass RS.

J Mol Cell Cardiol. 2009 Aug;47(2):326-34. doi: 10.1016/j.yjmcc.2009.04.003. Epub 2009 Apr 14.


Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity.

Lovelock JD, Monasky MM, Jeong EM, Lardin HA, Liu H, Patel BG, Taglieri DM, Gu L, Kumar P, Pokhrel N, Zeng D, Belardinelli L, Sorescu D, Solaro RJ, Dudley SC Jr.

Circ Res. 2012 Mar 16;110(6):841-50. doi: 10.1161/CIRCRESAHA.111.258251. Epub 2012 Feb 16.


Ranolazine improves diastolic function in spontaneously hypertensive rats.

Williams S, Pourrier M, McAfee D, Lin S, Fedida D.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H867-81. doi: 10.1152/ajpheart.00704.2013. Epub 2014 Jan 24.


The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome.

Qi X, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJ, Kodama I, Nattel S.

Circ Arrhythm Electrophysiol. 2009 Jun;2(3):295-304. doi: 10.1161/CIRCEP.108.815654. Epub 2009 Apr 17.


Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.

Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC.

J Pharmacol Exp Ther. 2011 May;337(2):513-23. doi: 10.1124/jpet.110.176776. Epub 2011 Feb 16.


Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1068-79. doi: 10.1152/ajpheart.00401.2013. Epub 2013 Jul 19.

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