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Items: 1 to 20 of 101

1.

Apocynin and raisanberine alleviate intermittent hypoxia induced abnormal StAR and 3β-HSD and low testosterone by suppressing endoplasmic reticulum stress and activated p66Shc in rat testes.

Zhang GL, Dai DZ, Zhang C, Dai Y.

Reprod Toxicol. 2013 Apr;36:60-70. doi: 10.1016/j.reprotox.2012.12.002. Epub 2012 Dec 25.

PMID:
23270704
2.
3.

CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines.

Zhang GL, Yu F, Dai DZ, Cheng YS, Zhang C, Dai Y.

Acta Pharmacol Sin. 2012 Apr;33(4):470-8. doi: 10.1038/aps.2011.175. Epub 2012 Mar 19.

4.

Raisanberine protected pulmonary arterial rings and cardiac myocytes of rats against hypoxia injury by suppressing NADPH oxidase and calcium influx.

Gao J, Tang YQ, Dai DZ, Cheng YS, Zhang GL, Zhang C, Dai Y.

Acta Pharmacol Sin. 2012 May;33(5):625-34. doi: 10.1038/aps.2012.7.

5.

AQP4 KO exacerbating renal dysfunction is mediated by endoplasmic reticulum stress and p66Shc and is attenuated by apocynin and endothelin antagonist CPU0213.

Cheng YS, Dai DZ, Dai Y.

Eur J Pharmacol. 2013 Dec 5;721(1-3):249-58. doi: 10.1016/j.ejphar.2013.09.028. Epub 2013 Oct 14.

PMID:
24135202
6.

hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis.

Park SJ, Kim TS, Park CK, Lee SH, Kim JM, Lee KS, Lee IK, Park JW, Lawson MA, Lee DS.

J Mol Endocrinol. 2013 Feb 15;50(2):151-66. doi: 10.1530/JME-12-0195. Print 2013 Apr.

7.

Isoproterenol induced stressful reactions in the brain are characterized by inflammation due to activation of NADPH oxidase and ER stress: attenuated by Apocynin, Rehmannia complex and Triterpene acids.

Mo GL, Li Y, Du RH, Dai DZ, Cong XD, Dai Y.

Neurochem Res. 2014 Apr;39(4):719-30. doi: 10.1007/s11064-014-1260-z. Epub 2014 Feb 26.

PMID:
24570113
8.

Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.

Cheng YS, Cong XD, Dai DZ, Zhang Y, Dai Y.

J Pharm Pharmacol. 2013 Jan;65(1):94-101. doi: 10.1111/j.2042-7158.2012.01565.x. Epub 2012 Jul 24.

PMID:
23215692
9.

Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells.

Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J.

Toxicology. 2007 Apr 11;232(3):170-82. Epub 2007 Jan 16.

PMID:
17280759
10.

Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan.

Kumar V, Chakraborty A, Kural MR, Roy P.

Reprod Toxicol. 2009 Apr;27(2):177-85. doi: 10.1016/j.reprotox.2008.12.002. Epub 2008 Dec 11.

PMID:
19118620
11.

Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats.

Elumalai P, Krishnamoorthy G, Selvakumar K, Arunkumar R, Venkataraman P, Arunakaran J.

Reprod Toxicol. 2009 Jan;27(1):41-5. doi: 10.1016/j.reprotox.2008.11.053. Epub 2008 Nov 24.

PMID:
19071209
12.

Advanced glycation end products inhibit testosterone secretion by rat Leydig cells by inducing oxidative stress and endoplasmic reticulum stress.

Zhao YT, Qi YW, Hu CY, Chen SH, Liu Y.

Int J Mol Med. 2016 Aug;38(2):659-65. doi: 10.3892/ijmm.2016.2645. Epub 2016 Jun 16.

PMID:
27315604
13.

Effects of neonatal exposure to 4-tert-octylphenol, diethylstilbestrol, and flutamide on steroidogenesis in infantile rat testis.

Mikkilä TF, Toppari J, Paranko J.

Toxicol Sci. 2006 Jun;91(2):456-66. Epub 2006 Mar 14.

PMID:
16537657
14.

High-fat diet aggravates 2,2',4,4'-tetrabromodiphenyl ether-inhibited testosterone production via DAX-1 in Leydig cells in rats.

Zhang Z, Yu Y, Xu H, Wang C, Ji M, Gu J, Yang L, Zhu J, Dong H, Wang SL.

Toxicol Appl Pharmacol. 2017 May 15;323:1-8. doi: 10.1016/j.taap.2017.03.010. Epub 2017 Mar 12.

PMID:
28300557
15.

Benzo[a]pyrene reduces testosterone production in rat Leydig cells via a direct disturbance of testicular steroidogenic machinery.

Chung JY, Kim YJ, Kim JY, Lee SG, Park JE, Kim WR, Yoon YD, Yoo KS, Yoo YH, Kim JM.

Environ Health Perspect. 2011 Nov;119(11):1569-74. doi: 10.1289/ehp.1003391. Epub 2011 Jul 7.

16.

CPUY11018, an azimilide derivative, ameliorates isoproterenol-induced cardiac insufficiency through relieving dysfunctional mitochondria and endoplasmic reticulum.

Li M, Tang YQ, Du RH, Shi FH, Hussein HK, Dai DZ, Dai Y.

J Pharm Pharmacol. 2015 Aug;67(8):1029-41. doi: 10.1111/jphp.12401. Epub 2015 Apr 1.

PMID:
25828246
17.

Hypoxia alters pharmacokinetics of argirein because of mitochondrial dysfunction that is alleviated by apocynin.

Zhang YM, Yu F, Dai DZ, Gao J, Cong XD, Dai Y.

J Pharm Pharmacol. 2013 Sep;65(9):1360-72. doi: 10.1111/jphp.12098. Epub 2013 Jul 8.

PMID:
23927475
18.

Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system.

Feng Y, Zhang Q, Dai DZ, Ying HJ, Dai Y.

Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1131-7.

PMID:
17880366
19.

Modulation of antioxidant defense system by the environmental fungicide carbendazim in Leydig cells of rats.

Rajeswary S, Kumaran B, Ilangovan R, Yuvaraj S, Sridhar M, Venkataraman P, Srinivasan N, Aruldhas MM.

Reprod Toxicol. 2007 Nov-Dec;24(3-4):371-80. Epub 2007 Apr 5.

PMID:
17485193
20.

Orexin A-mediated stimulation of 3β-HSD expression and testosterone production through MAPK signaling pathways in primary rat Leydig cells.

Zheng D, Zhao Y, Shen Y, Chang X, Ju S, Guo L.

J Endocrinol Invest. 2014 Mar;37(3):285-92.

PMID:
24515297

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