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Items: 1 to 20 of 100

1.

Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b.

Zhang Q, Qi S, Xu M, Yu L, Tao Y, Deng Z, Wu W, Li J, Chen Z, Wong J.

Cell Res. 2013 Feb;23(2):225-41. doi: 10.1038/cr.2012.177. Epub 2012 Dec 25.

2.

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG.

Mol Cell. 2010 Jul 30;39(2):222-33. doi: 10.1016/j.molcel.2010.07.008.

3.

A novel mammalian flavin-dependent histone demethylase.

Karytinos A, Forneris F, Profumo A, Ciossani G, Battaglioli E, Binda C, Mattevi A.

J Biol Chem. 2009 Jun 26;284(26):17775-82. doi: 10.1074/jbc.M109.003087. Epub 2009 Apr 30.

4.

LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.

Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YG.

Mol Cell. 2013 Feb 7;49(3):558-70. doi: 10.1016/j.molcel.2012.11.019. Epub 2012 Dec 20.

5.

Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide.

Kakizawa T, Mizukami T, Itoh Y, Hasegawa M, Sasaki R, Suzuki T.

Bioorg Med Chem Lett. 2016 Feb 15;26(4):1193-5. doi: 10.1016/j.bmcl.2016.01.036. Epub 2016 Jan 16.

PMID:
26794039
6.

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function.

Yang Z, Jiang J, Stewart MD, Qi S, Yamane K, Li J, Zhang Y, Wong J.

Cell Res. 2010 Mar;20(3):276-87. doi: 10.1038/cr.2010.12. Epub 2010 Jan 26. Erratum in: Cell Res. 2010 Jul;20(7):858. Stewart, David M [corrected to Stewart, M David].

7.

Structural insight into substrate recognition by histone demethylase LSD2/KDM1b.

Chen F, Yang H, Dong Z, Fang J, Wang P, Zhu T, Gong W, Fang R, Shi YG, Li Z, Xu Y.

Cell Res. 2013 Feb;23(2):306-9. doi: 10.1038/cr.2013.17. Epub 2013 Jan 29. No abstract available.

8.

Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.

Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y.

Breast Cancer Res Treat. 2014 Jul;146(1):99-108. doi: 10.1007/s10549-014-3012-9. Epub 2014 Jun 13.

PMID:
24924415
9.

Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism.

Chang Y, Wu J, Tong XJ, Zhou JQ, Ding J.

Biochem J. 2011 Jan 15;433(2):295-302. doi: 10.1042/BJ20101418.

PMID:
21067515
10.

Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2).

Mino K, Nishimura S, Ninomiya S, Tujii H, Matsumori Y, Tsuchida M, Hosoi M, Koseki K, Wada S, Hasegawa M, Sasaki R, Murakami-Yamaguchi Y, Narita H, Suzuki T, Miyata N, Mizukami T.

Biosci Biotechnol Biochem. 2014;78(6):1010-7. doi: 10.1080/09168451.2014.910104. Epub 2014 Jun 13.

PMID:
25036127
11.

Crystal structure of human histone lysine-specific demethylase 1 (LSD1).

Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6.

12.

Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.

Yang Y, Yin X, Yang H, Xu Y.

Mol Cell. 2015 Apr 2;58(1):47-59. doi: 10.1016/j.molcel.2015.01.038. Epub 2015 Mar 12.

13.

Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.

Baron R, Binda C, Tortorici M, McCammon JA, Mattevi A.

Structure. 2011 Feb 9;19(2):212-20. doi: 10.1016/j.str.2011.01.001.

14.

Structural insights into histone lysine demethylation.

Hou H, Yu H.

Curr Opin Struct Biol. 2010 Dec;20(6):739-48. doi: 10.1016/j.sbi.2010.09.006. Epub 2010 Oct 21. Review.

15.

Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination.

Huang F, Ramakrishnan S, Pokhrel S, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB.

J Biol Chem. 2015 Nov 27;290(48):28760-77. doi: 10.1074/jbc.M115.693085. Epub 2015 Oct 8.

16.

Structural insights into a novel histone demethylase PHF8.

Yu L, Wang Y, Huang S, Wang J, Deng Z, Zhang Q, Wu W, Zhang X, Liu Z, Gong W, Chen Z.

Cell Res. 2010 Feb;20(2):166-73. doi: 10.1038/cr.2010.8. Epub 2010 Jan 26.

PMID:
20101266
17.

Crystal structure and mechanism of human lysine-specific demethylase-1.

Stavropoulos P, Blobel G, Hoelz A.

Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25.

PMID:
16799558
18.

The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.

Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte JC, Pinna LA, Sarno S.

Biochim Biophys Acta. 2014 Apr;1844(4):722-9. doi: 10.1016/j.bbapap.2014.01.014. Epub 2014 Jan 31.

PMID:
24486797
19.

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.

Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H.

Nat Struct Mol Biol. 2007 Jun;14(6):535-9. Epub 2007 May 27.

PMID:
17529991
20.

Structural insights into histone demethylation by JMJD2 family members.

Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G.

Cell. 2006 May 19;125(4):691-702. Epub 2006 May 4.

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