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Items: 1 to 20 of 110

1.

Potential role of acid ceramidase in conversion of cytostatic to cytotoxic end-point in pancreatic cancer cells.

Morad SA, Messner MC, Levin JC, Abdelmageed N, Park H, Merrill AH Jr, Cabot MC.

Cancer Chemother Pharmacol. 2013 Mar;71(3):635-45. doi: 10.1007/s00280-012-2050-4. Epub 2012 Dec 21.

PMID:
23263160
2.

Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells.

Messner MC, Cabot MC.

Cancer Chemother Pharmacol. 2011 Aug;68(2):477-87. doi: 10.1007/s00280-010-1504-9. Epub 2010 Nov 12.

PMID:
21072519
3.

C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.

Flowers M, Fabriás G, Delgado A, Casas J, Abad JL, Cabot MC.

Breast Cancer Res Treat. 2012 Jun;133(2):447-58. doi: 10.1007/s10549-011-1768-8. Epub 2011 Sep 21.

PMID:
21935601
4.

Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells.

Morad SA, Levin JC, Tan SF, Fox TE, Feith DJ, Cabot MC.

Biochim Biophys Acta. 2013 Dec;1831(12):1657-64. doi: 10.1016/j.bbalip.2013.07.016. Epub 2013 Aug 9.

PMID:
23939396
5.

Targeting acid ceramidase sensitises head and neck cancer to cisplatin.

Roh JL, Park JY, Kim EH, Jang HJ.

Eur J Cancer. 2016 Jan;52:163-72. doi: 10.1016/j.ejca.2015.10.056. Epub 2015 Dec 11.

PMID:
26687835
6.

Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.

Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C.

J Biol Chem. 2015 May 22;290(21):13157-67. doi: 10.1074/jbc.M114.631325. Epub 2015 Apr 3.

7.

Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of P-glycoprotein.

Azare J, Pankova-Kholmyansky I, Salnikow K, Cohen D, Flescher E.

Oncol Res. 2001;12(8):315-23.

PMID:
11589302
8.

Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.

Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR Jr, Bielawska A, Norris JS, Liu X.

J Clin Invest. 2013 Oct;123(10):4344-58. doi: 10.1172/JCI64791. Epub 2013 Sep 16.

9.

Cytotoxicity and acid ceramidase inhibitory activity of 2-substituted aminoethanol amides.

Bedia C, Canals D, Matabosch X, Harrak Y, Casas J, Llebaria A, Delgado A, Fabriás G.

Chem Phys Lipids. 2008 Nov;156(1-2):33-40. doi: 10.1016/j.chemphyslip.2008.07.012. Epub 2008 Aug 8.

PMID:
18760267
10.

Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide.

Turner LS, Cheng JC, Beckham TH, Keane TE, Norris JS, Liu X.

Prostate Cancer Prostatic Dis. 2011 Mar;14(1):30-7. doi: 10.1038/pcan.2010.47. Epub 2010 Nov 30.

11.

Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.

Gouazé-Andersson V, Flowers M, Karimi R, Fabriás G, Delgado A, Casas J, Cabot MC.

Prostate. 2011 Jul;71(10):1064-73. doi: 10.1002/pros.21321. Epub 2010 Dec 28.

PMID:
21557271
12.

Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION.

Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D.

J Biol Chem. 2016 Jan 29;291(5):2422-34. doi: 10.1074/jbc.M115.666909. Epub 2015 Nov 9.

13.

Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells.

Suzuki R, Kang Y, Li X, Roife D, Zhang R, Fleming JB.

Anticancer Res. 2014 Sep;34(9):4685-92.

15.

Ceramide--antiestrogen nanoliposomal combinations--novel impact of hormonal therapy in hormone-insensitive breast cancer.

Morad SA, Levin JC, Shanmugavelandy SS, Kester M, Fabrias G, Bedia C, Cabot MC.

Mol Cancer Ther. 2012 Nov;11(11):2352-61. doi: 10.1158/1535-7163.MCT-12-0594. Epub 2012 Sep 7.

16.

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

Newman RA, Kondo Y, Yokoyama T, Dixon S, Cartwright C, Chan D, Johansen M, Yang P.

Integr Cancer Ther. 2007 Dec;6(4):354-64.

PMID:
18048883
17.
18.

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.

Liu X, Cheng JC, Turner LS, Elojeimy S, Beckham TH, Bielawska A, Keane TE, Hannun YA, Norris JS.

Expert Opin Ther Targets. 2009 Dec;13(12):1449-58. doi: 10.1517/14728220903357512. Review.

19.

Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity.

Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D.

Sci Rep. 2013;3:1035. doi: 10.1038/srep01035. Epub 2013 Jan 8.

20.

The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines.

Boukes GJ, van de Venter M.

Biomed Pharmacother. 2016 Oct;83:617-626. doi: 10.1016/j.biopha.2016.07.029. Epub 2016 Jul 25.

PMID:
27459118

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