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Items: 1 to 20 of 80

1.

Interferon-lambda (IFN-λ) induces signal transduction and gene expression in human hepatocytes, but not in lymphocytes or monocytes.

Dickensheets H, Sheikh F, Park O, Gao B, Donnelly RP.

J Leukoc Biol. 2013 Mar;93(3):377-85. doi: 10.1189/jlb.0812395. Epub 2012 Dec 20.

2.

IFN-λ Inhibits MiR-122 Transcription through a Stat3-HNF4α Inflammatory Feedback Loop in an IFN-α Resistant HCV Cell Culture System.

Aboulnasr F, Hazari S, Nayak S, Chandra PK, Panigrahi R, Ferraris P, Chava S, Kurt R, Song K, Dash A, Balart LA, Garry RF, Wu T, Dash S.

PLoS One. 2015 Dec 11;10(12):e0141655. doi: 10.1371/journal.pone.0141655. eCollection 2015.

3.

Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells.

Kohli A, Zhang X, Yang J, Russell RS, Donnelly RP, Sheikh F, Sherman A, Young H, Imamichi T, Lempicki RA, Masur H, Kottilil S.

J Viral Hepat. 2012 Dec;19(12):843-53. doi: 10.1111/j.1365-2893.2012.01610.x. Epub 2012 May 27.

4.

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

Ferraris P, Chandra PK, Panigrahi R, Aboulnasr F, Chava S, Kurt R, Pawlotsky JM, Wilkens L, Osterlund P, Hartmann R, Balart LA, Wu T, Dash S.

Am J Pathol. 2016 Apr;186(4):938-51. doi: 10.1016/j.ajpath.2015.11.027. Epub 2016 Feb 16.

PMID:
26896692
5.

HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons.

Thomas E, Gonzalez VD, Li Q, Modi AA, Chen W, Noureddin M, Rotman Y, Liang TJ.

Gastroenterology. 2012 Apr;142(4):978-88. doi: 10.1053/j.gastro.2011.12.055. Epub 2012 Jan 13.

6.

Pegylated interferons Lambda-1a and alfa-2a display different gene induction and cytokine and chemokine release profiles in whole blood, human hepatocytes and peripheral blood mononuclear cells.

Freeman J, Baglino S, Friborg J, Kraft Z, Gray T, Hill M, McPhee F, Hillson J, Lopez-Talavera JC, Wind-Rotolo M.

J Viral Hepat. 2014 Jun;21(6):e1-9. doi: 10.1111/jvh.12243.

PMID:
24827902
7.

Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics.

Marcello T, Grakoui A, Barba-Spaeth G, Machlin ES, Kotenko SV, MacDonald MR, Rice CM.

Gastroenterology. 2006 Dec;131(6):1887-98. Epub 2006 Oct 1.

PMID:
17087946
8.

Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo.

Makowska Z, Duong FH, Trincucci G, Tough DF, Heim MH.

Hepatology. 2011 Apr;53(4):1154-63. doi: 10.1002/hep.24189.

PMID:
21480323
9.

Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication.

Zhu H, Butera M, Nelson DR, Liu C.

Virol J. 2005 Sep 7;2:80.

10.

STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α.

Yamauchi S, Takeuchi K, Chihara K, Honjoh C, Kato Y, Yoshiki H, Hotta H, Sada K.

Sci Rep. 2016 Dec 8;6:38336. doi: 10.1038/srep38336.

11.

Isolation and characterization of interferon lambda-resistant hepatitis C virus replicon cell lines.

Friborg J, Lin B, Chen C, McPhee F.

Virology. 2013 Sep;444(1-2):384-93. doi: 10.1016/j.virol.2013.07.005. Epub 2013 Jul 25.

12.

Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection.

Stoltz M, Klingström J.

J Virol. 2010 Sep;84(18):9140-8. doi: 10.1128/JVI.00717-10. Epub 2010 Jun 30.

13.

Impairment of type I but not type III IFN signaling by hepatitis C virus infection influences antiviral responses in primary human hepatocytes.

Friborg J, Ross-Macdonald P, Cao J, Willard R, Lin B, Eggers B, McPhee F.

PLoS One. 2015 Mar 31;10(3):e0121734. doi: 10.1371/journal.pone.0121734. eCollection 2015.

14.

Acetaldehyde accelerates HCV-induced impairment of innate immunity by suppressing methylation reactions in liver cells.

Ganesan M, Zhang J, Bronich T, Poluektova LI, Donohue TM Jr, Tuma DJ, Kharbanda KK, Osna NA.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 1;309(7):G566-77. doi: 10.1152/ajpgi.00183.2015. Epub 2015 Aug 6.

15.

Chaperone-Mediated Autophagy Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated HCV Cell Culture.

Kurt R, Chandra PK, Aboulnasr F, Panigrahi R, Ferraris P, Aydin Y, Reiss K, Wu T, Balart LA, Dash S.

PLoS One. 2015 May 11;10(5):e0125962. doi: 10.1371/journal.pone.0125962. eCollection 2015.

16.

Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.

Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kröger A.

Gastroenterology. 2013 Dec;145(6):1414-23.e1. doi: 10.1053/j.gastro.2013.08.037. Epub 2013 Aug 21.

PMID:
23973921
17.

IFN-λ3 inhibits HIV infection of macrophages through the JAK-STAT pathway.

Liu MQ, Zhou DJ, Wang X, Zhou W, Ye L, Li JL, Wang YZ, Ho WZ.

PLoS One. 2012;7(4):e35902. doi: 10.1371/journal.pone.0035902. Epub 2012 Apr 27.

18.

Interferon alpha induced intrahepatic pSTAT1 inversely correlate with serum HCV RNA levels in chronic HCV infection.

Gunduz F, Mallikarjun C, Balart LA, Dash S.

Exp Mol Pathol. 2014 Feb;96(1):36-41. doi: 10.1016/j.yexmp.2013.10.016. Epub 2013 Nov 8.

19.

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C.

FEBS Lett. 2013 May 21;587(10):1571-8. doi: 10.1016/j.febslet.2013.03.041. Epub 2013 Apr 12.

20.

Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus.

Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S, Luther J, Kumthip K, Urban TJ, Peng LF, Lauer GM, Chung RT.

Hepatology. 2014 Apr;59(4):1250-61. doi: 10.1002/hep.26653. Epub 2014 Feb 14.

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