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Items: 1 to 20 of 167

1.

Glutathione transport: a new role for PfCRT in chloroquine resistance.

Patzewitz EM, Salcedo-Sora JE, Wong EH, Sethia S, Stocks PA, Maughan SC, Murray JA, Krishna S, Bray PG, Ward SA, Müller S.

Antioxid Redox Signal. 2013 Sep 1;19(7):683-95. doi: 10.1089/ars.2012.4625. Epub 2012 Dec 20.

2.

Functional Comparison of 45 Naturally Occurring Isoforms of the Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT).

Callaghan PS, Hassett MR, Roepe PD.

Biochemistry. 2015 Aug 18;54(32):5083-94. doi: 10.1021/acs.biochem.5b00412. Epub 2015 Aug 6.

3.

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.

Summers RL, Martin RE.

Virulence. 2010 Jul-Aug;1(4):304-8. doi: 10.4161/viru.1.4.12012.

PMID:
21178460
4.

Chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Martin RE, Marchetti RV, Cowan AI, Howitt SM, Bröer S, Kirk K.

Science. 2009 Sep 25;325(5948):1680-2. doi: 10.1126/science.1175667.

5.

Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.

Papakrivos J, Sá JM, Wellems TE.

PLoS One. 2012;7(6):e39569. doi: 10.1371/journal.pone.0039569. Epub 2012 Jun 19.

6.

Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.

Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE.

PLoS Pathog. 2016 Jul 21;12(7):e1005725. doi: 10.1371/journal.ppat.1005725. eCollection 2016 Jul.

7.

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

Bray PG, Mungthin M, Hastings IM, Biagini GA, Saidu DK, Lakshmanan V, Johnson DJ, Hughes RH, Stocks PA, O'Neill PM, Fidock DA, Warhurst DC, Ward SA.

Mol Microbiol. 2006 Oct;62(1):238-51. Epub 2006 Aug 31.

8.

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum.

Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE.

ACS Chem Biol. 2014 Mar 21;9(3):722-30. doi: 10.1021/cb4008953. Epub 2014 Jan 6.

9.

Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.

Cabrera M, Natarajan J, Paguio MF, Wolf C, Urbach JS, Roepe PD.

Biochemistry. 2009 Oct 13;48(40):9471-81. doi: 10.1021/bi901034r.

10.

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

Valderramos SG, Valderramos JC, Musset L, Purcell LA, Mercereau-Puijalon O, Legrand E, Fidock DA.

PLoS Pathog. 2010 May 13;6(5):e1000887. doi: 10.1371/journal.ppat.1000887.

11.

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.

van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE.

J Infect Dis. 2016 Mar 1;213(5):800-10. doi: 10.1093/infdis/jiv509. Epub 2015 Oct 26.

PMID:
26503982
12.

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.

Gabryszewski SJ, Modchang C, Musset L, Chookajorn T, Fidock DA.

Mol Biol Evol. 2016 Jun;33(6):1554-70. doi: 10.1093/molbev/msw037. Epub 2016 Feb 22.

13.

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine.

Dhingra SK, Redhi D, Combrinck JM, Yeo T, Okombo J, Henrich PP, Cowell AN, Gupta P, Stegman ML, Hoke JM, Cooper RA, Winzeler E, Mok S, Egan TJ, Fidock DA.

MBio. 2017 May 9;8(3). pii: e00303-17. doi: 10.1128/mBio.00303-17.

14.

Analysis of Plasmodium vivax Chloroquine Resistance Transporter Mutant Isoforms.

Hassett MR, Riegel BE, Callaghan PS, Roepe PD.

Biochemistry. 2017 Oct 17;56(41):5615-5622. doi: 10.1021/acs.biochem.7b00749. Epub 2017 Sep 26.

PMID:
28898049
15.

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter.

Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1759-67. doi: 10.1073/pnas.1322965111. Epub 2014 Apr 11.

16.

A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum.

Edaye S, Reiling SJ, Leimanis ML, Wunderlich J, Rohrbach P, Georges E.

Mol Biochem Parasitol. 2014 Jun;195(1):34-42. doi: 10.1016/j.molbiopara.2014.05.006. Epub 2014 Jun 8.

PMID:
24914817
17.
18.

High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia.

Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G.

Malar J. 2014 Mar 27;13:120. doi: 10.1186/1475-2875-13-120.

19.

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

Lehane AM, Kirk K.

Mol Microbiol. 2010 Aug;77(4):1039-51. doi: 10.1111/j.1365-2958.2010.07272.x. Epub 2010 Jun 28.

20.

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu AB, Fidock DA.

EMBO J. 2005 Jul 6;24(13):2294-305. Epub 2005 Jun 9.

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