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Items: 1 to 20 of 247


Use of molecular modelling to probe the mechanism of the nucleoside transporter NupG.

Vaziri H, Baldwin SA, Baldwin JM, Adams DG, Young JD, Postis VL.

Mol Membr Biol. 2013 Mar;30(2):114-28. doi: 10.3109/09687688.2012.748939. Epub 2012 Dec 21.


The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands.

Patching SG, Baldwin SA, Baldwin AD, Young JD, Gallagher MP, Henderson PJ, Herbert RB.

Org Biomol Chem. 2005 Feb 7;3(3):462-70. Epub 2005 Jan 10.


Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease.

Kasho VN, Smirnova IN, Kaback HR.

J Mol Biol. 2006 May 12;358(4):1060-70. Epub 2006 Mar 9.


Purification and properties of the Escherichia coli nucleoside transporter NupG, a paradigm for a major facilitator transporter sub-family.

Xie H, Patching SG, Gallagher MP, Litherland GJ, Brough AR, Venter H, Yao SY, Ng AM, Young JD, Herbert RB, Henderson PJ, Baldwin SA.

Mol Membr Biol. 2004 Sep-Oct;21(5):323-36.


Conservation of residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease.

Vadyvaloo V, Smirnova IN, Kasho VN, Kaback HR.

J Mol Biol. 2006 May 12;358(4):1051-9. Epub 2006 Mar 9.


Sugar recognition by CscB and LacY.

Sugihara J, Smirnova I, Kasho V, Kaback HR.

Biochemistry. 2011 Dec 27;50(51):11009-14. doi: 10.1021/bi201592y. Epub 2011 Dec 1.


Crystal structure of the bacterial nucleoside transporter Tsx.

Ye J, van den Berg B.

EMBO J. 2004 Aug 18;23(16):3187-95. Epub 2004 Jul 22.


Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition.

Chaptal V, Kwon S, Sawaya MR, Guan L, Kaback HR, Abramson J.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9361-6. doi: 10.1073/pnas.1105687108. Epub 2011 May 18.


The alternating-access mechanism of MFS transporters arises from inverted-topology repeats.

Radestock S, Forrest LR.

J Mol Biol. 2011 Apr 15;407(5):698-715. doi: 10.1016/j.jmb.2011.02.008. Epub 2011 Feb 18.


Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å.

Johnson ZL, Cheong CG, Lee SY.

Nature. 2012 Mar 11;483(7390):489-93. doi: 10.1038/nature10882.


Structure and mechanism of the lactose permease.

Kaback HR.

C R Biol. 2005 Jun;328(6):557-67. Review.


Structure and mechanism of the lactose permease of Escherichia coli.

Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S.

Science. 2003 Aug 1;301(5633):610-5.


A proton-mediated conformational shift identifies a mobile pore-lining cysteine residue (Cys-561) in human concentrative nucleoside transporter 3.

Slugoski MD, Ng AM, Yao SY, Smith KM, Lin CC, Zhang J, Karpinski E, Cass CE, Baldwin SA, Young JD.

J Biol Chem. 2008 Mar 28;283(13):8496-507. doi: 10.1074/jbc.M710433200. Epub 2008 Jan 16.


Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily.

Abramson J, Kaback HR, Iwata S.

Curr Opin Struct Biol. 2004 Aug;14(4):413-9. Review.


Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition.

Cano-Soldado P, Pastor-Anglada M.

Med Res Rev. 2012 Mar;32(2):428-57. doi: 10.1002/med.20221. Epub 2011 Feb 1. Review.


Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters.

Johnson ZL, Lee JH, Lee K, Lee M, Kwon DY, Hong J, Lee SY.

Elife. 2014 Jul 31;3:e03604. doi: 10.7554/eLife.03604.


Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A.

Jiang D, Zhao Y, Wang X, Fan J, Heng J, Liu X, Feng W, Kang X, Huang B, Liu J, Zhang XC.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14664-9. doi: 10.1073/pnas.1308127110. Epub 2013 Aug 15.


Substituted cysteine accessibility method analysis of human concentrative nucleoside transporter hCNT3 reveals a novel discontinuous region of functional importance within the CNT family motif (G/A)XKX3NEFVA(Y/M/F).

Slugoski MD, Ng AM, Yao SY, Lin CC, Mulinta R, Cass CE, Baldwin SA, Young JD.

J Biol Chem. 2009 Jun 19;284(25):17281-92. doi: 10.1074/jbc.M109.009704. Epub 2009 Apr 20.

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