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Structural-functional studies of Burkholderia cenocepacia D-glycero-β-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.

Lee TW, Verhey TB, Antiperovitch PA, Atamanyuk D, Desroy N, Oliveira C, Denis A, Gerusz V, Drocourt E, Loutet SA, Hamad MA, Stanetty C, Andres SN, Sugiman-Marangos S, Kosma P, Valvano MA, Moreau F, Junop MS.

J Med Chem. 2013 Feb 28;56(4):1405-17. doi: 10.1021/jm301483h. Epub 2013 Jan 22.


Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis.

Kim MS, Lim A, Yang SW, Park J, Lee D, Shin DH.

Acta Crystallogr D Biol Crystallogr. 2013 Apr;69(Pt 4):658-68. doi: 10.1107/S0907444913001030. Epub 2013 Mar 14.


Systematic synthesis of inhibitors of the two first enzymes of the bacterial heptose biosynthetic pathway: towards antivirulence molecules targeting lipopolysaccharide biosynthesis.

Durka M, Tikad A, Périon R, Bosco M, Andaloussi M, Floquet S, Malacain E, Moreau F, Oxoby M, Gerusz V, Vincent SP.

Chemistry. 2011 Sep 26;17(40):11305-13. doi: 10.1002/chem.201100396. Epub 2011 Aug 26. Erratum in: Chemistry. 2011 Dec 16;17(51):14319.


Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.

Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P.

J Biol Chem. 2001 Jun 15;276(24):20935-44. Epub 2001 Mar 28.


Expression and crystallographic studies of D-glycero-β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.

Park J, Kim H, Kim S, Lee D, Shin DH.

Acta Crystallogr F Struct Biol Commun. 2017 Feb 1;73(Pt 2):90-94. doi: 10.1107/S2053230X16020537. Epub 2017 Jan 19.


Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).

Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D.

Biochemistry. 2010 Feb 16;49(6):1072-81. doi: 10.1021/bi902018y.


Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.

Ortega X, Silipo A, Saldías MS, Bates CC, Molinaro A, Valvano MA.

J Biol Chem. 2009 Aug 7;284(32):21738-51. doi: 10.1074/jbc.M109.008532. Epub 2009 Jun 12.


The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-beta-D-mannose suggests a one base mechanism.

Kowatz T, Morrison JP, Tanner ME, Naismith JH.

Protein Sci. 2010 Jul;19(7):1337-43. doi: 10.1002/pro.410.


Towards Gram-negative antivirulence drugs: new inhibitors of HldE kinase.

Desroy N, Moreau F, Briet S, Le Fralliec G, Floquet S, Durant L, Vongsouthi V, Gerusz V, Denis A, Escaich S.

Bioorg Med Chem. 2009 Feb 1;17(3):1276-89. doi: 10.1016/j.bmc.2008.12.021. Epub 2008 Dec 24.


A two-base mechanism for Escherichia coli ADP-L-glycero-D-manno-heptose 6-epimerase.

Morrison JP, Tanner ME.

Biochemistry. 2007 Mar 27;46(12):3916-24. Epub 2007 Feb 23.


Burkholderia cenocepacia lectin A binding to heptoses from the bacterial lipopolysaccharide.

Marchetti R, Malinovska L, Lameignère E, Adamova L, de Castro C, Cioci G, Stanetty C, Kosma P, Molinaro A, Wimmerova M, Imberty A, Silipo A.

Glycobiology. 2012 Oct;22(10):1387-98. doi: 10.1093/glycob/cws105. Epub 2012 Jul 3.


The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site.

Harmer NJ.

J Mol Biol. 2010 Jul 16;400(3):379-92. doi: 10.1016/j.jmb.2010.04.058. Epub 2010 May 4.


The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist.

Deacon AM, Ni YS, Coleman WG Jr, Ealick SE.

Structure. 2000 May 15;8(5):453-62.


Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli.

Taylor PL, Sugiman-Marangos S, Zhang K, Valvano MA, Wright GD, Junop MS.

Biochemistry. 2010 Feb 9;49(5):1033-41. doi: 10.1021/bi901780j.


Burkholderia cenocepacia BC2L-C is a super lectin with dual specificity and proinflammatory activity.

Sulák O, Cioci G, Lameignère E, Balloy V, Round A, Gutsche I, Malinovská L, Chignard M, Kosma P, Aubert DF, Marolda CL, Valvano MA, Wimmerová M, Imberty A.

PLoS Pathog. 2011 Sep;7(9):e1002238. doi: 10.1371/journal.ppat.1002238. Epub 2011 Sep 1.


Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.

Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS.

J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3.


Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.

Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC.

PLoS One. 2012;7(3):e33481. doi: 10.1371/journal.pone.0033481. Epub 2012 Mar 16.


Chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose and study of the substrate specificity of HldE.

Li T, Wen L, Williams A, Wu B, Li L, Qu J, Meisner J, Xiao Z, Fang J, Wang PG.

Bioorg Med Chem. 2014 Feb 1;22(3):1139-47. doi: 10.1016/j.bmc.2013.12.019. Epub 2013 Dec 19.

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