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Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1.

Denard B, Lee C, Ye J.

Elife. 2012 Dec 18;1:e00090. doi: 10.7554/eLife.00090.


Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome.

Denard B, Pavia-Jimenez A, Chen W, Williams NS, Naina H, Collins R, Brugarolas J, Ye J.

PLoS One. 2015 Jun 25;10(6):e0129233. doi: 10.1371/journal.pone.0129233. eCollection 2015.


How does doxorubicin work?

Patel AG, Kaufmann SH.

Elife. 2012 Dec 18;1:e00387. doi: 10.7554/eLife.00387.


OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.

Rose M, Schubert C, Dierichs L, Gaisa NT, Heer M, Heidenreich A, Knüchel R, Dahl E.

Epigenetics. 2014 Dec;9(12):1626-40. doi: 10.4161/15592294.2014.988052.


The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells.

Denard B, Seemann J, Chen Q, Gay A, Huang H, Chen Y, Ye J.

Cell Host Microbe. 2011 Jul 21;10(1):65-74. doi: 10.1016/j.chom.2011.06.006.


Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1.

Chen Q, Lee CE, Denard B, Ye J.

PLoS One. 2014 Oct 13;9(10):e108528. doi: 10.1371/journal.pone.0108528. eCollection 2014.


Analysis of ATF6 activation in Site-2 protease-deficient Chinese hamster ovary cells.

Nadanaka S, Yoshida H, Sato R, Mori K.

Cell Struct Funct. 2006;31(2):109-16. Epub 2006 Nov 17.


Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.

Guan M, Fousek K, Jiang C, Guo S, Synold T, Xi B, Shih CC, Chow WA.

Clin Cancer Res. 2011 Apr 1;17(7):1796-806. doi: 10.1158/1078-0432.CCR-10-3216. Epub 2011 Feb 25.


Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells.

Bar-On O, Shapira M, Hershko DD.

Anticancer Drugs. 2007 Nov;18(10):1113-21.


Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death.

Buranrat B, Connor JR.

Oncol Rep. 2015 Nov;34(5):2790-6. doi: 10.3892/or.2015.4250. Epub 2015 Sep 8.


Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor.

Wang X, Lin C, Zhao X, Liu A, Zhu J, Li X, Song L.

Mol Cancer. 2014 May 8;13:106. doi: 10.1186/1476-4598-13-106.


Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis.

Xu Y, Diao Y, Qi S, Pan X, Wang Q, Xin Y, Cao X, Ruan J, Zhao Z, Luo L, Liu C, Yin Z.

Cell Signal. 2013 May;25(5):1176-85. doi: 10.1016/j.cellsig.2013.01.017. Epub 2013 Jan 26.


Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation.

Catalano S, Giordano C, Rizza P, Gu G, Barone I, Bonofiglio D, Giordano F, Malivindi R, Gaccione D, Lanzino M, De Amicis F, Andò S.

J Cell Physiol. 2009 Mar;218(3):490-500. doi: 10.1002/jcp.21622.


The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.

Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z.

Cancer Discov. 2012 Jul;2(7):638-51. doi: 10.1158/2159-8290.CD-12-0093. Epub 2012 May 10.


FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells.

Martin BT, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, Strebhardt K.

Cell Cycle. 2007 Jul 15;6(14):1779-88.


Loss of O⁶-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells.

Raguz S, Adams C, Masrour N, Rasul S, Papoutsoglou P, Hu Y, Cazzanelli G, Zhou Y, Patel N, Coombes C, Yagüe E.

Biochem Pharmacol. 2013 Jan 15;85(2):186-96. doi: 10.1016/j.bcp.2012.10.020. Epub 2012 Oct 30.


Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).

Wei M, Liu B, Gu Q, Su L, Yu Y, Zhu Z.

Cell Oncol (Dordr). 2013 Feb;36(1):79-93. doi: 10.1007/s13402-012-0115-3. Epub 2012 Nov 27.


NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.

Clark DW, Mitra A, Fillmore RA, Jiang WG, Samant RS, Fodstad O, Shevde LA.

Curr Cancer Drug Targets. 2008 Aug;8(5):421-30.


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