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Items: 1 to 20 of 104

1.

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.

Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R.

Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43. doi: 10.1128/AAC.00959-12. Epub 2012 Dec 17.

2.

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.

Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J.

Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17.

3.

Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.

Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, Grosenbach DW.

Antimicrob Agents Chemother. 2015 Jul;59(7):4296-300. doi: 10.1128/AAC.00208-15. Epub 2015 Apr 20.

4.

Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.

Duraffour S, Andrei G, Snoeck R.

IDrugs. 2010 Mar;13(3):181-91. Review.

PMID:
20191435
5.

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.

Stittelaar KJ, Neyts J, Naesens L, van Amerongen G, van Lavieren RF, HolĂ˝ A, De Clercq E, Niesters HG, Fries E, Maas C, Mulder PG, van der Zeijst BA, Osterhaus AD.

Nature. 2006 Feb 9;439(7077):745-8. Epub 2005 Dec 11.

PMID:
16341204
6.

In vitro efficacy of ST246 against smallpox and monkeypox.

Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK.

Antimicrob Agents Chemother. 2009 Mar;53(3):1007-12. doi: 10.1128/AAC.01044-08. Epub 2008 Dec 15.

7.

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, Hruby D.

Antimicrob Agents Chemother. 2009 Jun;53(6):2620-5. doi: 10.1128/AAC.00021-09. Epub 2009 Apr 6.

8.

A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.

Stabenow J, Buller RM, Schriewer J, West C, Sagartz JE, Parker S.

J Virol. 2010 Apr;84(8):3909-20. doi: 10.1128/JVI.02012-09. Epub 2010 Feb 3.

9.

Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).

Mucker EM, Goff AJ, Shamblin JD, Grosenbach DW, Damon IK, Mehal JM, Holman RC, Carroll D, Gallardo N, Olson VA, Clemmons CJ, Hudson P, Hruby DE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6246-53. doi: 10.1128/AAC.00977-13. Epub 2013 Oct 7.

10.

Tecovirimat for smallpox infections.

Bolken TC, Hruby DE.

Drugs Today (Barc). 2010 Feb;46(2):109-17. doi: 10.1358/dot.2010.46.2.1437244.

PMID:
20393639
11.

New effective chemically synthesized anti-smallpox compound NIOCH-14.

Mazurkov OY, Kabanov AS, Shishkina LN, Sergeev AA, Skarnovich MO, Bormotov NI, Skarnovich MA, Ovchinnikova AS, Titova KA, Galahova DO, Bulychev LE, Sergeev AA, Taranov OS, Selivanov BA, Tikhonov AY, Zavjalov EL, Agafonov AP, Sergeev AN.

J Gen Virol. 2016 May;97(5):1229-39. doi: 10.1099/jgv.0.000422. Epub 2016 Feb 8.

PMID:
26861777
12.

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.

Parker S, Chen NG, Foster S, Hartzler H, Hembrador E, Hruby D, Jordan R, Lanier R, Painter G, Painter W, Sagartz JE, Schriewer J, Mark Buller R.

Antiviral Res. 2012 Apr;94(1):44-53. doi: 10.1016/j.antiviral.2012.02.005. Epub 2012 Feb 18.

13.

Molecule of the month. Tecovirimat.

[No authors listed]

Drug News Perspect. 2008 Nov;21(9):517. No abstract available.

PMID:
19180269
14.

Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation.

Realegeno S, Puschnik AS, Kumar A, Goldsmith C, Burgado J, Sambhara S, Olson VA, Carroll D, Damon I, Hirata T, Kinoshita T, Carette JE, Satheshkumar PS.

J Virol. 2017 May 12;91(11). pii: e00011-17. doi: 10.1128/JVI.00011-17. Print 2017 Jun 1.

15.

[THE USE OF THE MODEL MOUSE ICR--VARIOLA VIRUS FOR EVALUATION OF ANTIVIRAL DRUG EFFICACY].

Titova KA, Sergeev AA, Kabanov AS, Bulychev LE, Sergeev AA, Galakhova DO, Shishkina LN, Zamedyanskaya AS, Nesterov AE, Glotov AG, Taranov OS, Omigov VV, Agafonov AP, Sergeev AN.

Vopr Virusol. 2016;61(2):79-84. Russian.

PMID:
27451500
16.

Experimental infection of cynomolgus macaques (Macaca fascicularis) with aerosolized monkeypox virus.

Nalca A, Livingston VA, Garza NL, Zumbrun EE, Frick OM, Chapman JL, Hartings JM.

PLoS One. 2010 Sep 20;5(9). pii: e12880. doi: 10.1371/journal.pone.0012880.

17.

ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.

Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW.

Antimicrob Agents Chemother. 2009 Dec;53(12):4999-5009. doi: 10.1128/AAC.00678-09. Epub 2009 Sep 14.

18.

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

Sbrana E, Jordan R, Hruby DE, Mateo RI, Xiao SY, Siirin M, Newman PC, DA Rosa AP, Tesh RB.

Am J Trop Med Hyg. 2007 Apr;76(4):768-73.

PMID:
17426185
19.

Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections.

Baker RO, Bray M, Huggins JW.

Antiviral Res. 2003 Jan;57(1-2):13-23.

PMID:
12615299
20.

Infection of cynomolgus macaques with a recombinant monkeypox virus encoding green fluorescent protein.

Goff A, Mucker E, Raymond J, Fisher R, Bray M, Hensley L, Paragas J.

Arch Virol. 2011 Oct;156(10):1877-81. doi: 10.1007/s00705-011-1065-1. Epub 2011 Aug 4.

PMID:
21814864

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