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Items: 1 to 20 of 257

1.

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength.

Zhang L, Patapoff T, Farnan D, Zhang B.

J Chromatogr A. 2013 Jan 11;1272:56-64. doi: 10.1016/j.chroma.2012.11.060. Epub 2012 Nov 29.

PMID:
23253120
2.

Multiproduct high-resolution monoclonal antibody charge variant separations by pH gradient ion-exchange chromatography.

Farnan D, Moreno GT.

Anal Chem. 2009 Nov 1;81(21):8846-57. doi: 10.1021/ac901408j.

PMID:
19795895
3.

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations.

Rea JC, Moreno GT, Lou Y, Farnan D.

J Pharm Biomed Anal. 2011 Jan 25;54(2):317-23. doi: 10.1016/j.jpba.2010.08.030. Epub 2010 Sep 29.

PMID:
20884149
4.

Charge heterogeneity profiling of monoclonal antibodies using low ionic strength ion-exchange chromatography and well-controlled pH gradients on monolithic columns.

Talebi M, Nordborg A, Gaspar A, Lacher NA, Wang Q, He XZ, Haddad PR, Hilder EF.

J Chromatogr A. 2013 Nov 22;1317:148-54. doi: 10.1016/j.chroma.2013.08.061. Epub 2013 Aug 21.

PMID:
24011724
5.

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part I: salt gradient approach.

Fekete S, Beck A, Fekete J, Guillarme D.

J Pharm Biomed Anal. 2015 Jan;102:33-44. doi: 10.1016/j.jpba.2014.08.035. Epub 2014 Sep 8.

PMID:
25240157
6.

pH-gradient ion-exchange chromatography: an analytical tool for design and optimization of protein separations.

Ahamed T, Nfor BK, Verhaert PD, van Dedem GW, van der Wielen LA, Eppink MH, van de Sandt EJ, Ottens M.

J Chromatogr A. 2007 Sep 14;1164(1-2):181-8. Epub 2007 Jul 27.

PMID:
17673242
7.

Monoclonal antibody heterogeneity analysis and deamidation monitoring with high-performance cation-exchange chromatofocusing using simple, two component buffer systems.

Kang X, Kutzko JP, Hayes ML, Frey DD.

J Chromatogr A. 2013 Mar 29;1283:89-97. doi: 10.1016/j.chroma.2013.01.101. Epub 2013 Jan 31.

PMID:
23428023
8.

Separation of protein mixtures using pH-gradient cation-exchange chromatography.

Ng PK, He J, Snyder MA.

J Chromatogr A. 2009 Feb 27;1216(9):1372-6. doi: 10.1016/j.chroma.2008.12.100. Epub 2009 Jan 9.

PMID:
19168182
9.

Method development for the separation of monoclonal antibody charge variants in cation exchange chromatography, Part II: pH gradient approach.

Fekete S, Beck A, Fekete J, Guillarme D.

J Pharm Biomed Anal. 2015 Jan;102:282-9. doi: 10.1016/j.jpba.2014.09.032. Epub 2014 Oct 5.

PMID:
25459925
10.

Characterization of monoclonal antibodies using polymeric cation exchange monoliths in combination with salt and pH gradients.

Nordborg A, Zhang B, He XZ, Hilder EF, Haddad PR.

J Sep Sci. 2009 Aug;32(15-16):2668-73. doi: 10.1002/jssc.200900283.

PMID:
19606447
11.

pH-based cation exchange chromatography in the capture and elution of monoclonal antibodies.

Ng PK, Snyder MA.

J Sep Sci. 2012 Jan;35(1):29-35. doi: 10.1002/jssc.201100720. Epub 2011 Nov 28.

PMID:
22125292
12.

Capillary ion-exchange chromatography with nanogram sensitivity for the analysis of monoclonal antibodies.

Rea JC, Freistadt BS, McDonald D, Farnan D, Wang YJ.

J Chromatogr A. 2015 Dec 11;1424:77-85. doi: 10.1016/j.chroma.2015.11.002. Epub 2015 Nov 4.

PMID:
26596872
13.

Semiautomated pH gradient ion-exchange chromatography of monoclonal antibody charge variants.

Talebi M, Shellie RA, Hilder EF, Lacher NA, Haddad PR.

Anal Chem. 2014 Oct 7;86(19):9794-9. doi: 10.1021/ac502372r. Epub 2014 Sep 16.

PMID:
25199803
14.

pH-conductivity hybrid gradient cation-exchange chromatography for process-scale monoclonal antibody purification.

Zhou JX, Dermawan S, Solamo F, Flynn G, Stenson R, Tressel T, Guhan S.

J Chromatogr A. 2007 Dec 14;1175(1):69-80. Epub 2007 Oct 17.

PMID:
17980374
15.

Effects of salt-induced reversible self-association on the elution behavior of a monoclonal antibody in cation exchange chromatography.

Luo H, Macapagal N, Newell K, Man A, Parupudi A, Li Y, Li Y.

J Chromatogr A. 2014 Oct 3;1362:186-93. doi: 10.1016/j.chroma.2014.08.048. Epub 2014 Aug 20.

16.

Application of linear pH gradients for the modeling of ion exchange chromatography: Separation of monoclonal antibody monomer from aggregates.

Kluters S, Wittkopp F, Jöhnck M, Frech C.

J Sep Sci. 2016 Feb;39(4):663-75. doi: 10.1002/jssc.201500994. Epub 2015 Dec 15.

PMID:
26549715
17.

Avoiding antibody aggregation during processing: establishing hold times.

Joshi V, Shivach T, Kumar V, Yadav N, Rathore A.

Biotechnol J. 2014 Sep;9(9):1195-205. doi: 10.1002/biot.201400052. Epub 2014 May 12.

PMID:
24753430
18.

Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range.

Lingg N, Tan E, Hintersteiner B, Bardor M, Jungbauer A.

J Chromatogr A. 2013 Dec 6;1319:65-71. doi: 10.1016/j.chroma.2013.10.028. Epub 2013 Oct 16.

PMID:
24183595
19.

Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1).

Gillespie R, Nguyen T, Macneil S, Jones L, Crampton S, Vunnum S.

J Chromatogr A. 2012 Aug 17;1251:101-10. doi: 10.1016/j.chroma.2012.06.037. Epub 2012 Jun 20.

PMID:
22771262
20.

Rapid analysis of charge variants of monoclonal antibodies using non-linear salt gradient in cation-exchange high performance liquid chromatography.

Joshi V, Kumar V, Rathore AS.

J Chromatogr A. 2015 Aug 7;1406:175-85. doi: 10.1016/j.chroma.2015.06.015. Epub 2015 Jun 14.

PMID:
26118807

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