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Items: 1 to 20 of 200

1.

Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice.

Zhang LN, Zhou HY, Fu YY, Li YY, Wu F, Gu M, Wu LY, Xia CM, Dong TC, Li JY, Shen JK, Li J.

Diabetes. 2013 Apr;62(4):1297-307. doi: 10.2337/db12-0703. Epub 2012 Dec 18.

2.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

3.

Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes.

Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti ME.

FASEB J. 2010 Apr;24(4):1003-14. doi: 10.1096/fj.09-133728. Epub 2009 Nov 11.

4.
5.

Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN.

J Biol Chem. 2006 Jul 14;281(28):19000-8. Epub 2006 May 2.

7.

PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle.

Pagel-Langenickel I, Bao J, Joseph JJ, Schwartz DR, Mantell BS, Xu X, Raghavachari N, Sack MN.

J Biol Chem. 2008 Aug 15;283(33):22464-72. doi: 10.1074/jbc.M800842200. Epub 2008 Jun 25.

8.

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.

9.

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.

Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M.

Nat Med. 2012 Mar 18;18(4):612-7. doi: 10.1038/nm.2691.

PMID:
22426420
10.

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

Diabetes. 2009 Jul;58(7):1499-508. doi: 10.2337/db08-1571. Epub 2009 Apr 14.

11.

Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. doi: 10.1152/ajpendo.90292.2008. Epub 2009 Feb 10.

13.

Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.

Summermatter S, Baum O, Santos G, Hoppeler H, Handschin C.

J Biol Chem. 2010 Oct 22;285(43):32793-800. doi: 10.1074/jbc.M110.145995. Epub 2010 Aug 17.

14.

Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway.

Zheng X, Sun T, Wang X.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):377-81. doi: 10.1016/j.bbrc.2013.05.108. Epub 2013 Jun 4.

PMID:
23747418
15.

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity.

Summermatter S, Troxler H, Santos G, Handschin C.

Biochem Biophys Res Commun. 2011 Apr 29;408(1):180-5. doi: 10.1016/j.bbrc.2011.04.012. Epub 2011 Apr 8.

PMID:
21501593
16.

Resveratrol and SRT1720 Elicit Differential Effects in Metabolic Organs and Modulate Systemic Parameters Independently of Skeletal Muscle Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α).

Svensson K, Schnyder S, Albert V, Cardel B, Quagliata L, Terracciano LM, Handschin C.

J Biol Chem. 2015 Jun 26;290(26):16059-76. doi: 10.1074/jbc.M114.590653. Epub 2015 May 18.

17.
18.

Nitric oxide and AMPK cooperatively regulate PGC-1 in skeletal muscle cells.

Lira VA, Brown DL, Lira AK, Kavazis AN, Soltow QA, Zeanah EH, Criswell DS.

J Physiol. 2010 Sep 15;588(Pt 18):3551-66. doi: 10.1113/jphysiol.2010.194035. Epub 2010 Jul 19.

19.
20.

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.

Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2931-6. doi: 10.1073/pnas.1115813109. Epub 2012 Feb 3.

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