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Items: 1 to 20 of 93

1.

Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.

Hwang SS, Kim YU, Lee S, Jang SW, Kim MK, Koh BH, Lee W, Kim J, Souabni A, Busslinger M, Lee GR.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):276-81. doi: 10.1073/pnas.1214682110. Epub 2012 Dec 17.

2.

Aberrant expression of IFN-γ in Th2 cells from Th2 LCR-deficient mice.

Hwang SS, Kim K, Lee W, Lee GR.

Biochem Biophys Res Commun. 2012 Aug 3;424(3):512-8. doi: 10.1016/j.bbrc.2012.06.146. Epub 2012 Jul 3.

PMID:
22771806
3.

RHS6-mediated chromosomal looping and nuclear substructure binding is required for Th2 cytokine gene expression.

Hwang SS, Jang SW, Lee GR.

Biochim Biophys Acta. 2017 Mar;1860(3):383-391. doi: 10.1016/j.bbagrm.2017.01.008. Epub 2017 Jan 27.

PMID:
28132936
4.

Defective GATA-3 expression in Th2 LCR-deficient mice.

Hwang SS, Kim K, Lee GR.

Biochem Biophys Res Commun. 2011 Jul 15;410(4):866-71. doi: 10.1016/j.bbrc.2011.06.080. Epub 2011 Jun 15.

PMID:
21703230
5.

Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region.

Kim K, Kim N, Lee GR.

PLoS One. 2016 Feb 3;11(2):e0148576. doi: 10.1371/journal.pone.0148576. eCollection 2016.

6.

RHS6 coordinately regulates the Th2 cytokine genes by recruiting GATA3, SATB1, and IRF4.

Hwang SS, Jang SW, Lee KO, Kim HS, Lee GR.

Allergy. 2017 May;72(5):772-782. doi: 10.1111/all.13078. Epub 2016 Nov 23.

PMID:
27878828
7.

Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.

Hosokawa H, Tanaka T, Kato M, Shinoda K, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Yagi R, Sakikawa I, Morita A, Nagira M, Poyurovsky MV, Suzuki Y, Motohashi S, Nakayama T.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18626-31. doi: 10.1073/pnas.1311100110. Epub 2013 Oct 28.

8.

Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.

Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura MY, Tumes DJ, Motohashi S, Matsumoto M, Nakayama KI, Tanaka T, Nakayama T.

J Biol Chem. 2015 May 22;290(21):13095-103. doi: 10.1074/jbc.M114.621524. Epub 2015 Apr 10.

9.

Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expression.

Lee GR.

Transcription. 2014;5(2):e27976. doi: 10.4161/trns.27976.

10.

Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.

Yamashita M, Ukai-Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, Kimura M, Taniguchi M, DeGregori J, Nakayama T.

J Biol Chem. 2004 Jun 25;279(26):26983-90. Epub 2004 Apr 15.

11.

Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice.

Hasegawa A, Miki T, Hosokawa H, Hossain MB, Shimizu C, Hashimoto K, Kimura MY, Yamashita M, Nakayama T.

J Immunol. 2006 Feb 15;176(4):2546-54.

12.

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.

Williams A, Lee GR, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6955-60. doi: 10.1073/pnas.1304720110. Epub 2013 Apr 8.

13.

Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.

Lee DU, Rao A.

Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16010-5. Epub 2004 Oct 26.

14.

Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.

Ribeiro de Almeida C, Heath H, Krpic S, Dingjan GM, van Hamburg JP, Bergen I, van de Nobelen S, Sleutels F, Grosveld F, Galjart N, Hendriks RW.

J Immunol. 2009 Jan 15;182(2):999-1010.

15.

Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma.

Koh BH, Hwang SS, Kim JY, Lee W, Kang MJ, Lee CG, Park JW, Flavell RA, Lee GR.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10614-9. doi: 10.1073/pnas.1005383107. Epub 2010 May 18.

16.

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity.

Hosokawa H, Tanaka T, Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes DJ, Kanai A, Sugano S, Nakayama T.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4691-6. doi: 10.1073/pnas.1220865110. Epub 2013 Mar 7.

17.

Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3.

Horiuchi S, Onodera A, Hosokawa H, Watanabe Y, Tanaka T, Sugano S, Suzuki Y, Nakayama T.

J Immunol. 2011 Jun 1;186(11):6378-89. doi: 10.4049/jimmunol.1100179. Epub 2011 May 2.

18.

Regulation of the Th2 cytokine locus by a locus control region.

Lee GR, Fields PE, Griffin TJ, Flavell RA.

Immunity. 2003 Jul;19(1):145-53.

19.

GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2.

Hwang SS, Lee S, Lee W, Lee GR.

Immunology. 2010 Sep;131(1):50-8. doi: 10.1111/j.1365-2567.2010.03271.x. Epub 2010 Jul 16.

20.

c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus.

Kozuka T, Sugita M, Shetzline S, Gewirtz AM, Nakata Y.

J Immunol. 2011 Dec 1;187(11):5974-82. doi: 10.4049/jimmunol.1100550. Epub 2011 Oct 28.

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