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FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.

Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL.

J Mol Med (Berl). 2013 Mar;91(3):333-46. doi: 10.1007/s00109-012-0982-0. Epub 2012 Dec 18.


The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL.

J Mol Med (Berl). 2010 Jan;88(1):47-60. doi: 10.1007/s00109-009-0524-6. Epub 2009 Dec 1.


Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.

Fang YH, Piao L, Hong Z, Toth PT, Marsboom G, Bache-Wiig P, Rehman J, Archer SL.

J Mol Med (Berl). 2012 Jan;90(1):31-43. doi: 10.1007/s00109-011-0804-9. Epub 2011 Aug 28.


Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension.

Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL.

J Mol Med (Berl). 2013 Oct;91(10):1185-97. doi: 10.1007/s00109-013-1064-7. Epub 2013 Jun 21.


Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension.

Archer SL, Fang YH, Ryan JJ, Piao L.

Pulm Circ. 2013 Jan;3(1):144-52. doi: 10.4103/2045-8932.109960.


Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Mallinson JE, Constantin-Teodosiu D, Glaves PD, Martin EA, Davies WJ, Westwood FR, Sidaway JE, Greenhaff PL.

J Physiol. 2012 Dec 15;590(24):6389-402. doi: 10.1113/jphysiol.2012.238022. Epub 2012 Oct 8.


Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure.

Piao L, Marsboom G, Archer SL.

J Mol Med (Berl). 2010 Oct;88(10):1011-20. doi: 10.1007/s00109-010-0679-1. Epub 2010 Sep 4. Review.


CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.

Nahlé Z, Hsieh M, Pietka T, Coburn CT, Grimaldi PA, Zhang MQ, Das D, Abumrad NA.

J Biol Chem. 2008 May 23;283(21):14317-26. doi: 10.1074/jbc.M706478200. Epub 2008 Feb 28.


An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL.

Circulation. 2006 Jun 6;113(22):2630-41. Epub 2006 May 30.


The increase in cardiac pyruvate dehydrogenase kinase-4 after short-term dexamethasone is controlled by an Akt-p38-forkhead box other factor-1 signaling axis.

Puthanveetil P, Wang Y, Wang F, Kim MS, Abrahani A, Rodrigues B.

Endocrinology. 2010 May;151(5):2306-18. doi: 10.1210/en.2009-1072. Epub 2010 Feb 24.


GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

Piao L, Fang YH, Parikh KS, Ryan JJ, D'Souza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL.

Circulation. 2012 Dec 11;126(24):2859-69. doi: 10.1161/CIRCULATIONAHA.112.109868. Epub 2012 Nov 2.


Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response.

Chambers KT, Leone TC, Sambandam N, Kovacs A, Wagg CS, Lopaschuk GD, Finck BN, Kelly DP.

J Biol Chem. 2011 Apr 1;286(13):11155-62. doi: 10.1074/jbc.M110.217349. Epub 2011 Feb 14.


Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.

Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA.

J Biol Chem. 2006 Dec 29;281(52):39897-906. Epub 2006 Nov 1.


Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin.

Connaughton S, Chowdhury F, Attia RR, Song S, Zhang Y, Elam MB, Cook GA, Park EA.

Mol Cell Endocrinol. 2010 Feb 5;315(1-2):159-67. doi: 10.1016/j.mce.2009.08.011. Epub 2009 Aug 22.


Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension.

Okumura K, Kato H, Honjo O, Breitling S, Kuebler WM, Sun M, Friedberg MK.

J Mol Med (Berl). 2015 Jun;93(6):663-74. doi: 10.1007/s00109-015-1251-9. Epub 2015 Jan 18.


A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension.

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED.

J Mol Med (Berl). 2013 Nov;91(11):1315-27. doi: 10.1007/s00109-013-1059-4. Epub 2013 Jul 12.


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