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Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells.

Hu HY, Li KP, Wang XJ, Liu Y, Lu ZG, Dong RH, Guo HB, Zhang MX.

Acta Pharmacol Sin. 2013 Jan;34(1):157-66. doi: 10.1038/aps.2012.161. Epub 2012 Dec 17.


Genistein inhibits the proliferation of human multiple myeloma cells through suppression of nuclear factor-κB and upregulation of microRNA-29b.

Xie J, Wang J, Zhu B.

Mol Med Rep. 2016 Feb;13(2):1627-32. doi: 10.3892/mmr.2015.4740. Epub 2015 Dec 30.


Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.

Zhao F, Chen Y, Zeng LL, Li R, Zeng R, Wen L, Liu Y, Zhang C.

Acta Pharmacol Sin. 2010 Jun;31(6):733-40. doi: 10.1038/aps.2010.49.


Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis.

Yan W, Li R, He J, Du J, Hou J.

Cell Signal. 2015 Apr;27(4):851-9. doi: 10.1016/j.cellsig.2015.01.013. Epub 2015 Jan 30.


Downregulation of Sprouty homolog 2 by microRNA-21 inhibits proliferation, metastasis and invasion, however promotes the apoptosis of multiple myeloma cells.

Wang JH, Zhou WW, Cheng ST, Liu BX, Liu FR, Song JQ.

Mol Med Rep. 2015 Aug;12(2):1810-6. doi: 10.3892/mmr.2015.3567. Epub 2015 Mar 30.


NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis.

Ni H, Zhao W, Kong X, Li H, Ouyang J.

PLoS One. 2014 Apr 22;9(4):e95846. doi: 10.1371/journal.pone.0095846. eCollection 2014.


Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells.

Liang Y, Xu RZ, Zhang L, Zhao XY.

Acta Pharmacol Sin. 2009 Dec;30(12):1659-65. doi: 10.1038/aps.2009.167.


Human umbilical cord blood-derived stromal cells: a new resource for the proliferation and apoptosis of myeloma cells.

Gao L, Zhang C, Zhang X, Gao L, Hao L, Chen XH.

Hematology. 2014 Apr;19(3):148-57. doi: 10.1179/1607845413Y.0000000107. Epub 2013 Nov 25.


Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter.

Qing Y, Hu H, Liu Y, Feng T, Meng W, Jiang L, Sun Y, Yao Y.

Cell Biol Int. 2014 May;38(5):563-70.


Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shishodia S, Aggarwal BB.

Blood. 2007 Mar 15;109(6):2293-302. Epub 2006 Dec 12. Erratum in: Blood. 2013 Aug 15;122(7):1325-6.


Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.

Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB.

Cancer Res. 2008 Jul 1;68(13):5370-9. doi: 10.1158/0008-5472.CAN-08-0511.


PSMB4 promotes multiple myeloma cell growth by activating NF-κB-miR-21 signaling.

Zheng P, Guo H, Li G, Han S, Luo F, Liu Y.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):328-33. doi: 10.1016/j.bbrc.2015.01.110. Epub 2015 Feb 3.


Canonical nuclear factor kappaB pathway inhibition blocks myeloma cell growth and induces apoptosis in strong synergy with TRAIL.

Romagnoli M, Desplanques G, Maïga S, Legouill S, Dreano M, Bataille R, Barillé-Nion S.

Clin Cancer Res. 2007 Oct 15;13(20):6010-8.


Sinomenine inhibits breast cancer cell invasion and migration by suppressing NF-κB activation mediated by IL-4/miR-324-5p/CUEDC2 axis.

Song L, Liu D, Zhao Y, He J, Kang H, Dai Z, Wang X, Zhang S, Zan Y.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):705-10. doi: 10.1016/j.bbrc.2015.07.004. Epub 2015 Jul 10.


Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.

Li J, Shen L, Lu FR, Qin Y, Chen R, Li J, Li Y, Zhan HZ, He YQ.

Acta Pharmacol Sin. 2012 Feb;33(2):242-9. doi: 10.1038/aps.2011.152. Epub 2012 Jan 9.


Dehydroxymethylepoxyquinomicin, a novel nuclear factor-kappaB inhibitor, induces apoptosis in multiple myeloma cells in an IkappaBalpha-independent manner.

Tatetsu H, Okuno Y, Nakamura M, Matsuno F, Sonoki T, Taniguchi I, Uneda S, Umezawa K, Mitsuya H, Hata H.

Mol Cancer Ther. 2005 Jul;4(7):1114-20.

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