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LRP5 and LRP6 in development and disease.

Joiner DM, Ke J, Zhong Z, Xu HE, Williams BO.

Trends Endocrinol Metab. 2013 Jan;24(1):31-9. doi: 10.1016/j.tem.2012.10.003. Review.


Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

MacDonald BT, Semenov MV, Huang H, He X.

PLoS One. 2011;6(8):e23537. doi: 10.1371/journal.pone.0023537. Epub 2011 Aug 24.


Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.

MacDonald BT, He X.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a007880. doi: 10.1101/cshperspect.a007880. Review.


Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.

Goel S, Chin EN, Fakhraldeen SA, Berry SM, Beebe DJ, Alexander CM.

J Biol Chem. 2012 May 11;287(20):16454-66. doi: 10.1074/jbc.M112.362137. Epub 2012 Mar 20.


Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Ahn VE, Chu ML, Choi HJ, Tran D, Abo A, Weis WI.

Dev Cell. 2011 Nov 15;21(5):862-73. doi: 10.1016/j.devcel.2011.09.003. Epub 2011 Oct 13.


Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.

Zhong Z, Baker JJ, Zylstra-Diegel CR, Williams BO.

J Cell Biochem. 2012 Jan;113(1):31-8. doi: 10.1002/jcb.23324.


Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6.

Bourhis E, Wang W, Tam C, Hwang J, Zhang Y, Spittler D, Huang OW, Gong Y, Estevez A, Zilberleyb I, Rouge L, Chiu C, Wu Y, Costa M, Hannoush RN, Franke Y, Cochran AG.

Structure. 2011 Oct 12;19(10):1433-42. doi: 10.1016/j.str.2011.07.005. Epub 2011 Sep 22.


Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.

Haÿ E, Buczkowski T, Marty C, Da Nascimento S, Sonnet P, Marie PJ.

J Bone Miner Res. 2012 Sep;27(9):1852-63. doi: 10.1002/jbmr.1656.


LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation.

Chen J, Yan H, Ren DN, Yin Y, Li Z, He Q, Wo D, Ho MS, Chen Y, Liu Z, Yang J, Liu S, Zhu W.

Cell Signal. 2014 May;26(5):1068-74. doi: 10.1016/j.cellsig.2013.12.020. Epub 2014 Jan 8.


Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.

Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE.

Genes Dev. 2013 Nov 1;27(21):2305-19. doi: 10.1101/gad.228544.113.


Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.

Seo T, Sakon T, Nakazawa S, Nishioka A, Watanabe K, Matsumoto K, Akasaka M, Shioi N, Sawada H, Araki S.

FEBS J. 2017 Jun;284(11):1657-1671. doi: 10.1111/febs.14066. Epub 2017 Apr 20.


Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.

Riddle RC, Diegel CR, Leslie JM, Van Koevering KK, Faugere MC, Clemens TL, Williams BO.

PLoS One. 2013 May 10;8(5):e63323. doi: 10.1371/journal.pone.0063323. Print 2013.


The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.

Bao J, Zheng JJ, Wu D.

Sci Signal. 2012 May 15;5(224):pe22. doi: 10.1126/scisignal.2003028.


Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.

Chang MK, Kramer I, Keller H, Gooi JH, Collett C, Jenkins D, Ettenberg SA, Cong F, Halleux C, Kneissel M.

J Bone Miner Res. 2014 Jan;29(1):29-42. doi: 10.1002/jbmr.2059.


Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction.

Wang S, Yin J, Chen D, Nie F, Song X, Fei C, Miao H, Jing C, Ma W, Wang L, Xie S, Li C, Zeng R, Pan W, Hao X, Li L.

Nat Chem Biol. 2013 Sep;9(9):579-85. doi: 10.1038/nchembio.1309. Epub 2013 Jul 28.


LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells.

Peröbner I, Karow M, Jochum M, Neth P.

Int J Biochem Cell Biol. 2012 Nov;44(11):1970-82. doi: 10.1016/j.biocel.2012.07.025. Epub 2012 Aug 2.


Rational design of DKK3 structure-based small peptides as antagonists of Wnt signaling pathway and in silico evaluation of their efficiency.

Poorebrahim M, Sadeghi S, Rahimi H, Karimipoor M, Azadmanesh K, Mazlomi MA, Teimoori-Toolabi L.

PLoS One. 2017 Feb 24;12(2):e0172217. doi: 10.1371/journal.pone.0172217. eCollection 2017.


Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.

Zhang L, Bahety P, Ee PL.

Neurochem Int. 2015 Aug;87:13-21. doi: 10.1016/j.neuint.2015.05.001. Epub 2015 May 7.


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