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The activation of proteinase-activated receptor-1 (PAR1) promotes gastric cancer cell alteration of cellular morphology related to cell motility and invasion.

Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A.

Int J Oncol. 2013 Feb;42(2):565-73. doi: 10.3892/ijo.2012.1738. Epub 2012 Dec 14.


The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion.

Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A.

BMC Cancer. 2010 Aug 19;10:443. doi: 10.1186/1471-2407-10-443.


Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer.

Otsuki T, Fujimoto D, Hirono Y, Goi T, Yamaguchi A.

Int J Oncol. 2014 Dec;45(6):2287-94. doi: 10.3892/ijo.2014.2651. Epub 2014 Sep 15.


The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells.

Paradiso A, Cardone RA, Bellizzi A, Bagorda A, Guerra L, Tommasino M, Casavola V, Reshkin SJ.

Breast Cancer Res. 2004;6(6):R616-28. Epub 2004 Sep 13.


Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells.

Eitaki M, Yamamori T, Meike S, Yasui H, Inanami O.

BMC Cancer. 2012 Oct 12;12:469. doi: 10.1186/1471-2407-12-469.


PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells.

Loberg RD, Tantivejkul K, Craig M, Neeley CK, Pienta KJ.

J Cell Biochem. 2007 Aug 1;101(5):1292-300.


Involvement of protein kinase C and RhoA in protease-activated receptor 1-mediated F-actin reorganization and cell growth in rat cardiomyocytes.

Otani H, Yoshioka K, Nishikawa H, Inagaki C, Nakamura T.

J Pharmacol Sci. 2011;115(2):135-43. Epub 2011 Jan 18.


RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion.

Nguyen QD, Faivre S, Bruyneel E, Rivat C, Seto M, Endo T, Mareel M, Emami S, Gespach C.

FASEB J. 2002 Apr;16(6):565-76.


Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells.

Yufu T, Hirano K, Bi D, Hirano M, Nishimura J, Iwamoto Y, Kanaide H.

Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1506-11. Epub 2005 Apr 28.


Putative tumor metastasis-associated genes in human gastric cancer.

Tuan TF, Chung CT, Tsou HH, Chen FW, Lin HL, Lai YK, Lee WS, Chao YS, Hwang LL, Chen CT.

Int J Oncol. 2012 Sep;41(3):1068-84. doi: 10.3892/ijo.2012.1502. Epub 2012 May 31.


Protease-activated receptors (PAR1 and PAR2) contribute to tumor cell motility and metastasis.

Shi X, Gangadharan B, Brass LF, Ruf W, Mueller BM.

Mol Cancer Res. 2004 Jul;2(7):395-402.


Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin.

Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, Gutwein P, Altevogt P, Bar-Shavit R.

J Biol Chem. 2001 Apr 6;276(14):10952-62. Epub 2001 Jan 26.


Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.

Hatziapostolou M, Polytarchou C, Panutsopulos D, Covic L, Tsichlis PN.

Cancer Res. 2008 Mar 15;68(6):1851-61. doi: 10.1158/0008-5472.CAN-07-5793.


BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.

Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, Pintzas A.

Mol Cancer. 2011 Sep 23;10:118. doi: 10.1186/1476-4598-10-118.


Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Ramachandran R, Sadofsky LR, Xiao Y, Botham A, Cowen M, Morice AH, Compton SJ.

Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L788-98. Epub 2006 Dec 1.


Modulation of Rho GTPase activity in endothelial cells by selective proteinase-activated receptor (PAR) agonists.

Vouret-Craviari V, Grall D, Van Obberghen-Schilling E.

J Thromb Haemost. 2003 May;1(5):1103-11.


Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.

Adams HC 3rd, Chen R, Liu Z, Whitehead IP.

Breast Cancer Res. 2010;12(5):R69. doi: 10.1186/bcr2637. Epub 2010 Sep 6.

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